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Biomedical subjects

R Bertolini

Publications and source records attributed to R Bertolini.

49 records · Page 3Linked to original sources
PubMedDate not supplied

[Cystic pancreatic tumors. Review of literature and proposal of a diagnostic-therapeutic pathway].

In this paper the Authors consider the epidemiological, clinical, pathological, instrumental, chemical and physical findings of every type of pancreatic cystic lesions. They perform a critical examination of each of them. In this way, they can identify the most important features of every single class. A pathway consisting in four main groups of instrumental and chemical tests (abdominal ultrasonography / EUS, CT, MR, FNA / biopsy/ assay of tumoral markers and amylase of cystic fluid) was chosen to know all these informations according to careful principles of specificity, sensitivity and diagnostic accuracy taken from international scientific literature. In each subgroup of cystic pancreatic tumor, at last, the most reliable therapeutic project is suggested according to the common international scientific agreement.

Aged↗
PubMedDate not supplied

[Newborn infants from epileptic mothers: malformation and auxonologic risk].

A case-control study was performed to determine if newborns of epileptic mothers have a higher probability of having congenital malformations. Forty seven newborns of epileptic mothers and an equivalent number of controls with no history of epileptic disease and paired for mother's age, parity, type of education were examined. Thirty one mothers had been treated during the first term of pregnancy and 16 had not. A large number of anthropometric parameters were measured in each newborn to minimize the subjective component in diagnosing even minimal malformations and fetal growth abnormalities. To evaluate weight, length and head circumference the neonatal standards of Largo et al. were used. For all other measures the standards of Merlob et al. were used. Single absolute values of the parameters measured were converted into standard points to eliminate the effect of the sex and gestational age variables. The incidence of malformations was not seen to be significantly different in the newborns of epileptic mothers as a whole and divided into the two subgroups (treated and untreated) versus controls. The fetal syndromes described in literature were not observed. Of all the anthropometric measures examined only length was significantly reduced in newborns of epileptic mothers. Maternal epilepsy and its treatment do not appear to be a considerable risk factor for the newborn.

Abnormalities, Drug-Induced↗
PubMedDate not supplied

Comparative psychological aspects of two different types of chemotherapeutic administration (chronotherapy vs. traditional chemotherapy) on quality of life of cancer patients at advanced stage.

In addition to qualitative information, specific quantitative psychiatrics tests (regarding anxiety and depression) and objective psychological tests specific to cancer populations were used to compare psychological variables in two groups of metastatic cancer patients treated with chemotherapy. The study also recorded 24 possible symptoms (somatic and psychic) allowing the self-evaluation of individual quality of life. The evaluation was performed at 7 different times (from before the beginning of treatment up to the 6th course). In comparison to traditional treatment, the results showed a better psychosocial adaptation for patients receiving chronoprogrammed administration of anticancer medication, with better social relations, less feelings of loss of independence, less anxiety, depression, and somatic discomfort.

Chronobiology Phenomena↗
PubMedDate not supplied

[Comparison of bench central and mixed pulmonary venous oxygen saturation in critically ill postsurgical patients].

OBJECTIVE: To investigate if there were differences between bench central oxygen saturation (ScvO2) and mixed venous oxygen saturation (SvO2) in a group of acutely ill postsurgical patients. DESIGN: A prospective comparative study of two sampling sites. SETTING: Postsurgical ICU at a University Hospital. PATIENTS: 39 acutely ill postsurgical patients, requiring perioperative invasive hemodynamic monitoring, studied during their stay in a postsurgical ICU. INTERVENTIONS: Routine care for acutely ill postsurgical patients. MEASUREMENTS AND MAIN RESULTS: Blood was simultaneously sampled, according to the clinical course, both from the distal and central port of a pulmonary artery catheter (n = 296 each). Oxygen saturation and blood gas analysis were immediately measured with a CO-oxymeter and a blood gas analyzer. We investigated the relationship and the agreement between the two measures. To assess if bench ScVO2 could give information on time related variations of bench SvO2 we evaluated the absolute sequential changes of the two measures during the period of observation, by analyzing the relationship and the agreement of their absolute changes (n = 1817). There was a significant difference between bench SvO2 and bench ScvO2 (71.8 +/- 8.2 vs 72.7 +/- 8.6% mean +/- SD, p < 0.001). The relationship between the two measures showed a significant correlation (r = 0.90, p < 0.001, and SEE 3.8%). The bias was -0.93 +/- 3.8%, and the limits of agreement were +6.6 and -8.5%. The changes in bench ScvO2 correlated with the respective changes in bench SvO2 (r = 0.86, p < 0.001, and SEE 4.4%). The bias was 0.79 +/- 4.7% and the limits of agreement were +9.4 and -7.8%. CONCLUSIONS: SvO2 cannot be predicted well from bench ScvO2, nor changes in ScO2 can be predicted wel from changes in bench ScvO2. Therefore, in this category of patients, the clinical usefulness of monitoring bench ScvO2 is strongly limited and we must still rely on the SvO2.

Adolescent↗
PubMedDate not supplied

[Intestinal obstruction caused by paracecal hernia. 3 case reports and review of the literature].

The authors report three rare cases of intestinal obstruction due to paracecal hernia observed in 533 small bowel obstructions operated between January 1982 and December 1994 (0.6%). In our experience, all the cases occurred in old female patients. Less than 150 cases are reported in the literature. The authors examine paracecal hernia embryologic aspects to explain its pathogenesis: the rotation of primary intestinal loop determines final intestinal rapports. Preoperative diagnosis is very difficult. Transitory symptoms may appear months or years before intestinal obstruction; these occurrences suggest that internal hernias, like external ones, may spontaneously reduce. Straight abdominal radiographies, performed in all cases here described, demonstrate small bowel levels. There is disproportion between important subjective symptoms and objective finding of a large round bump localized in the right iliac fossa. Authors underline the opportunity of a promptly performed operation: in all our cases we released the incarcerated intestinal loops and sutured hernial foramen. One exitus occurred, on the 4th postoperative day, probably due to pulmonary embolism.

Age Factors↗