PubMed Health⌕ Search

Biomedical subjects

R C Briel

Publications and source records attributed to R C Briel.

At least 37 records · Page 2Linked to original sources
PubMed1980

The use of sulprostone, a prostaglandin E2 derivative, in intrauterine fetal death and therapeutic abortion.

The prostaglandin E2 derivative Sulprostone was used in the management of intrauterine fetal death and in therapeutic abortion in advanced pregnancy. While with extraamniotic administration there was a success rate of 50% after 24 hours, the rate of success was 86% after intramuscular administration. A cervix-ripening effect was not always observed by means of intracervical injection of Sulprostone. Such pre-treatment of the cervix did not improve the induction-abortion time after intramuscular administration of Sulprostone. Side effects were only slight following Sulprostone.

Abortion, Therapeutic↗
PubMed1980

[First experience with flavoxat in bladder - conditioned types of incontinence in gynaecology (author's transl)].

40 gynecological patients with motoric and sensoric urge incontinence were treated with the spasmolytic substance Flavoxat. Before treatment and after 4 weeks clinical and urodynamic evaluation were carried out. The results show that 65% of the patients improved under Flavoxat treatment. Incontinence was slightly improved in one third of the patients, in another third it was markedly improved or cured. An increased bladder capacity in the standing position and a decreased frequency of detrusor contractions was found in the urodynamic investigations. The residual urine remained constant.

Adult↗
PubMed1980

[Urodynamic findings in females following urinary incontinence operations. I: Anterior colporrhaphy (author's transl)].

In a retrospective study the effect of anterior colporrhaphy (mainly combined with vaginal hysterectomy) was analyzed using urodynamic and clinical data which were available in each patient before and after the operation. Two main samples were chosen: 106 patients with complete relief after the intervention (group I) and 43 women with recurrent incontinence (group II). Functional urethral length and maximum closure pressure were not significantly influenced by this operative procedure. However, in women belonging to group I--i.e. successfully treated--the urodynamic findings showed a clear tendency to more favourable values when compared with patients suffering from recurrent incontinence (alpha < 0,025). Our data indicate that urodynamic analysis of each patient before any vaginal operative procedures seems to be of clinical value to quantitate the success-rate of vaginal repair; patients with an unusual short urethra and low maximum closure pressure are not expected to be continent after anterior colporrhaphy.

Female↗
PubMed1980

[Urinary tract infections as a cause for urge incontinence? (author's transl)].

The clinical significance of urinary tract infections was investigated in a retrospective study in 160 patients with different types of urge-incontinence. The diagnosis of urge incontinence was entirely based on urethro-cystometry using the perfusion technique. Clinical signs of urgency were not necessarily evident. Motor urge incontinence was found in 83%, sensoric urge-incontinence in 17% of the patients. Urge-incontinence was rarely associated with urinary tract infection: significant bacteriuria was only found in 8.2%.

Adult↗
PubMed1980

[Initial clinical and cysto-urethral tonometric results with a new modification of the Marshall-Marchetti-Krantz-Operation].

From January 1976 to July 1978 a modified Marshall-Marchetti-Krantz-procedure for correction of urinary stress-incontinence was performed in 260 patients. A follow-up examination was done in 132 patients 6 weeks after surgery and in 96 pateints after 1 year. Urodynamic measurements were carred out in 66 patients, before and 1 year after after surgery. The incidence of perioperative complications was low, severe complications were found in less than 0.5%. Six weeks after surgery the subjective cure rate was 92%, after 1 year it was 80%. Cystoceles were corrected by the procedure and remained so in 87% one year after the operation. The urodynamic evaluations showed an increase of the maximal urethra-closure-pressure and, above all, a marked and significant improvement of the urethra-stress-profile. In 6 patients a motoric urge-incontinence was found at the follow-up examination after 1 year. The results of the new modification of the Marshall-Marchetti-Krantz-procedure are similar to those described in the literature after other operations for urinary stress-incontinence.

Adult↗
PubMed1979

Platelet function, coagulation and fibrinolysis during termination of missed abortion and missed labor by PGF2 alpha and oxytocin.

In cases of missed abortion and missed labor, labor was induced by PGF2 alpha i.a., i.v. and by oxytocin infusion. Platelet function (methods of Born and Breddin), the coagulation system and fibrinolysis have been studied within the three groups. Using PGF 2 alpha i.v., the initially increased platelet aggregation showed a tendency to become normal. There was no manifestation of activation of the coagulation system. Fibrinolytic activity showed a slight increase during PGF2 alpha i.v. No essential changes in platelet function, coagulation and fibrinolytic system were found after i.a. injection of PGF2 alpha. When inducing labor by oxytocin i.v., both the coagulation and the fibrinolytic system were slightly activated and platelet aggregation increased. The results and their clinical importance for hemostasis as well as therapeutic consequences are discussed.

Abortion, Missed↗
PubMed1978

Hematological studies in induction of abortion by extra-amniotic administration of sulproston.

The prostaglandin E2 derivative, Sulproston, was administered extra-amniotically for the induction of abortion in an average dosage of 200 microgram, in ten patients. With a success rate of 50%, the subjective side effects were very slight. Temperature, pulse rate, blood pressure and frequently of breathing did not change markedly. The ADP- and collagen-induced platelet aggregation showed a tendency to increase but disaggregation remained the same. Spontaneous platelet aggregation according to Breddin did not change. The parameters examined of the coagulation and fibrinolytic system showed only a slight increase in fibrinolytic activity during and after induction of abortion. The remaining hematological parameters showed no changes.

Abortifacient Agents↗
PubMed1978

Studies on platelet function during different modes of administration of PgF2alpha in obstetrics and gynecology.

Platelet function has been studied during intravenous, intraamniotic, and extraamniotic administration of prostaglandin F2alpha (PgF2alpha) for termination of missed abortion and missed labor, for therapeutic abortion, and for induction of term labor. The controls received oxytocin i.v. (missed labor and term labor). Our investigations have shown that there was a normalization of the increased spontaneous platelet aggregation and a significant reduction of ADP- and collagen-induced platelet aggregation in the groups given PgF2alpha i.v. The desaggregation in these groups was increased. The other groups given PgF2alpha showed no significant changes in platelet function. Inducing labor by oxytocin we found a tendency to increased platelet aggregation and decreased desaggregation. The clinical importance of these findings and the consequences for hemostasis are discussed.

Abortion, Missed↗
PubMed1978

[Platelet function during long term inhibition of labour by fenoterol/verapamil (author's transl)].

Platelet function has been studied in 22 patients (methods according to Born and Breddin) during tocolysis with long term administration of intravenous Fenoterol/Verapamil. The extend and speed of platelet aggregation, according to the Born test, were constant in the following 12 days except for a small increase on the second day. The phase of disaggregation remained unchanged. The reaction time to collagen was prolonged up to the 3rd-4th day. Spontaneous platelet aggregation showed a tendency to decrease up to day 3--4; thereafter, there was a return to the original values. The present data show that a hemostatic action in platelet function cannot be expected during long term tocolysis. Thus, there is no evidence that Fenoterol acts as an inhibitor of platelet aggregation in pregnancy.

Blood Platelets↗
PubMed1978

[Thrombocyte aggregation after vaginal hysterectomy with combined prevention of thromboembolism with macrodex 6% and sintrom].

The ADP- and collagen-induced thrombocyte aggregation has been investigated and statistically evaluated in 25 women. These patients had undergone vaginal hysterectomy and colporrhaphy due to descensus vaginae et uteri and received 500 ml Macrodex 6% during the operation and Sintrom from the 1st post-operative day as prophylactic treatment for early and late thromboembolism. After administration of dextran 60, the ability of the thrombocytes to aggregate was reduced by half, 2 hours post-operatively, independent of the concentration and type of agent added in the aggregation test, and remained at this level during the 1st post-operative day. The original values were once again attained on the 4th post-operative day. The speed and force of deaggregation showed reverse behaviour. There was no influence apparent due to age of the patient or phase of the cycle (proliferation, secretion and post-menopausal). By carrying out this combined prophylactic treatment for thromboembolism, satisfactory protection is provided in the dangerous phases during the operation and post-operatively.

Acenocoumarol↗
PubMed1978

[Influence on haemostasis exercised by Prostaglandin F2alpha in missed abortion (author's transl)].

The changes in the coagulation and the fibrinolytic system which may be related to the dead fetus syndrome indicate an interference of the activation of both coagulation and fibrinolysis. During termination of missed abortion and missed labour disorders of the haemostasis may occur acutely. In 16 patients with intrauterine death coagulation studies were performed inducing labour with PgF2alpha intraamniotically or i.v. No essentiel changes in the plasmatic system of coagulation and fibrinolysis were found. After i.a. application of PgF2alpha, the ADP- and collagen-induced as well as the spontaneous platelet aggregation didn't change. Using PgF2alpha i.v. a diminuation of the initially increased platelet aggregation was found in all parameters, whereas desaggregation was increased. These changes may influence an already existing latent consumption of coagulation factors in a favourable way. A further advantage of prostaglandins consists in the fact that smaller traumata occur, compared with curettage, so the possibility of liberation of thrombo-plastic material is reduced.

Abortion, Missed↗