PubMed Health⌕ Search

Biomedical subjects

R C Briel

Publications and source records attributed to R C Briel.

47 records · Page 3Linked to original sources
PubMed1978

[Changes of platelet function, coagulation and fibrinolysis during induction of labour at term by prostaglandin F2alpha and oxytocin (author's transl)].

Platelet function (induced and spontaneous aggregability according to Born and Breddin respectively) and some parameters of coagulation and fibrinolysis have been investiagted during induction of term labour by PgF2alpha i.v. (n = 9) and oxytocin i.v. (n = 9). During infusion of PgF2alpha there was a slight decrease of platelet aggregation with both methods. Desaggregation in the Born-test was increased. On the contrary there was no change of platelet function except a small increase of the speed of aggregation if one applicates oxytocin. The parameters of the plasmatic coagulation system remained almost unchanged in both groups and hint only at a slight increase of the fibrinolytic activity in the oxytocin group. The clinical importance of the results is discussed.

Blood Coagulation↗
PubMed1977

[Coagulation-physiological studies on the prevention of thromboembolism with dextran 60. I. The effect on platelet function].

Platelet aggregation, spreading capacity, adhesiveness (methods according to BREDDIN) have been investigated in 3 groups of 20 patients each after gynecological surgery. Group A (control group) got only 4-hydroxycumarin (Sintrom), group B--in addition to that--intraoperative 500 ml Dextran 60 (Macrodex 6%), group C 500 ml Dextran 60 as well intraoperative as on the 1., 2., 4., 7. and 10. day after surgery. The present data show that depending on the duration of Dextran application, platelet spreading capacity and adhesiveness are inhibited differently as to duration and extent. There was, above all, a reduction and with that a normalisation of the postoperatively increased spontaneous platelet aggregation. It is possible to influence the phase of early postoperative embolism in a favorable way by applicating Dextran already intraoperatively. After that one can use further infusions of Dextran, a prophylaxis by Cumarins or other anticoagulants. Giving dextran only once during surgery one can prove this normalisation of the increased platelet aggregation up to 24 hours postoperatively. By further infusions of Dextran 60 on the 1., 2., 4., 7. and 10. postoperative day it is possible to keep the extent of aggregation on a significantly reduced level till the complete mobilisation of the patient and consequently attain a protective effect on a possible development of deep venous thrombosis of the legs.

Cell Count↗
PubMed1977

[Coagulation-physiological studies on the prevention of thromboembolism with dextran 60. II. Changes in coagulation and fibrinolysis].

The postoperative behavior of different parameters of coagulation and fibrinolysis have been studied in three groups of 20 patients each. Group A got only 4-hydroxycumarin, group B 500 ml Dextran 60 intraoperatively in addition to that, group C 500 ml Dextran 60 during surgery and on the 1., 2., 4., 7. and 10. postoperative day. The results show that the hypercoagulability which occurs immediately after surgery can be prevented by infusion of Dextran 60. On the other hand there is no evidence that Dextran 60 may cause a consumptive coagulability. There is only little influence on fibrinolysis, so that no defect of haemostasis can be expected. So it is possible to use Dextran 60 both for bridging over the phase of early embolism after surgery until the change to other anticoagulants and as a substance which can be applicated for a longer period of time in prophylaxis of thromboembolism. It is referred to the additional properties of Dextran 60 in prevention of thrombosis due to reduction of blood viscosity and improvement of microcirculation.

4-Hydroxycoumarins↗
PubMedDate not supplied

[Prevention and therapy of deep venous thromboses in pregnancy].

This paper presents a review of the current status of prevention and treatment of thromboses in pregnancy and reports the author's own results. Thromboembolism prophylaxis during pregnancy is accomplished with low-dose heparin, and is recommended for patients with a history of thrombosis and/or embolism. Heparin does not permeate the placenta; therefore, long-term use of it in low doses does not involve a risk. Complication-free courses in 18 pregnancies during which low-dose heparin was administered by the author are described. In cases of manifest deep thrombosis in the iliofemoral vein during pregnancy it is advisable today to perform thrombectomy as an alternative to fibrinolysis. This is followed by continuous administration of heparin in a therapeutic doses. Primary heparin treatment is given for thromboses of the knee and lower leg. The individual therapeutic methods are compared on the basis of information in the literature and the author's personal experience with 34 cases. Coumarins should no longer be used during pregnancy. In view of the risk of osteoporosis under high-dose long-term heparinization, one should switch to coumarins as soon as possible post partum; the coumarins are only detectable in traces in the mother's milk. Deep thromboses during pregnancy can only be treated with some promise of success if there is optimal cooperation between gynecologist, hemostasiologist and, if necessary, a vascular surgeon.

Combined Modality Therapy↗
PubMedDate not supplied

[Prostacyclin sensitivity of thrombocytes and prostacyclin-like activity in the umbilical cord].

The present paper reports on determination of prostacyclin sensitivity of thrombocytes in the umbilical vein and prostacylin-like activity in the umbilical artery and vein in 16 umbilical cords. Prostacyclin sensitivity of the thrombocytes in the umbilical vein is significantly higher than in the venous blood of nonpregnant women and third-trimester gravidae. The higher the prostacyclin sensitivity of the thrombocytes, the lower the prostacyclin-like activity in the umbilical cord vessels. Prostacyclin-like activity in the umbilical vein is 1.3 times higher than in the umbilical artery. There is a positive correlation between the activity in the umbilical artery and that in the umbilical vein. No significant relations were found between the prostacyclin-like activity of the thrombocytes or respectively the prostacyclin-like activity, and the blood gas and multiple serum analysis values and birth parameters. The significance of the findings with regard to hemodynamics in the umbilical cord is discussed.

Epoprostenol↗
PubMedDate not supplied

Low-dose heparin prophylaxis and postoperative wound hematoma.

In a randomized study, 124 patients, undergoing abdominal hysterectomy, were examined for postoperative wound hematoma after receiving low-dose heparin or heparin-dihydroergotamin (DHE) prophylaxis. Different sites of injection were chosen, with or without subcutaneous administration of thrombin at the end of surgery. The postoperative incidence of wound hematoma was not improved by subcutaneous thrombin administration. There was no difference between the two types of prophylaxis. When heparin or heparin/DHE was injected in the upper arm, however, fewer hematomas were found than after injection in the abdominal region. Investigations of the coagulation and fibrinolytic systems showed no difference between the two types of prophylaxis and injection site. The administration of thrombin did not cause intravascular activation of the coagulation system.

Dihydroergotamine↗
PubMedDate not supplied

[ADP and collagen-induced thrombocyte aggregation in umbilical cord vein blood].

ADP and collagen induced platelet aggregation were determined in 34 newborns immediately after birth. Blood was drawn from the pulsating not clamped umbilical vein. Parameters of aggregation were correlated to pH values of umbilical artery and vein, Apgar score and to the duration of the first and second stage of labor. No significant correlations were found between parameters of labor and platelet aggregation. It is demonstrated, however, that a decrease of the pH values in the umbilical artery and vein is well correlated with an increase of the main parameters of platelet aggregation. Changes of disaggregation of platelets were only moderate, they showed a tendency to decrease with falling pH values. Altogether there is an increase of platelet aggregability if pH values go down. The results emphasize that the changes of platelet function described should be regarded in the concept of therapy of newborns with severe acidosis or shock as they may accentuate preexisting hypercoagulability.

Acidosis, Respiratory↗