Biomedical subjects
Publications and source records attributed to R Dabrowski.
The collagenous protein level in the inflammatory status of middle ear mucosa taken during the surgery in 16 patients were analysed. The more accentuated changes were in longer duration of disease. The collagenous protein level play probably an important role in the healing processes after tympanoplasty.
The effect of disodium cromoglycate on skin wound healing and collagen formation in the wounds was studied. Disodium cromoglycate (a mast cell stabilizer) administered to the rats in a dose of 2 mg/animal was found to retard wound healing and markedly increased wound surface in all examined days (3rd, 5th, 7th, 10th, 14th day of healing). The mast cell stabilizer injected directly into wounds decreased collagen content, especially on 10th and 14th day of the healing process.
The effects of exogenous histamine (Hi) and endogenous Hi (brought about by treatment with 48/80*] on the levels of collagen and glycosaminoglycans (GAG) in the skin of both newborns and their mothers were studied. Exogenous Hi injected into the mothers somewhat increased Hi level in the skin of the newborns and did not change the levels of collagen and GAG. 48/80 administered to the mothers resulted in a decrease of Hi in their skin and elevated it in skin of the newborns. The levels of collagen and GAG in the skin of the mothers were lower after 48/80 than in the control. However, 48/80 injected into the mothers resulted in an increase of collagen and GAG in skin of the newborns.
The studies were undertaken to investigate the influence of compound 48/80 on histamine (Hi) and collagen levels of chick embryos after administration of lathyrogen factor, beta-aminopropionitrile (BAPN). Hi and soluble collagen levels in bones (tibia and femur) and skin were significantly higher in the embryos treated with BAPN. Compound 48/80 administered together with BAPN lowered Hi and soluble collagen in the bones and skin as compared with the embryos treated with BAPN alone. Both, in the skin and bones, 48/80 was found to be a protective factor against the changes in biosynthesis of collagen.
The effects of aminoguanidine (a histamine inhibitor) and 48/80 (a histamine liberator) on the levels of histamine, soluble collagen fraction and total collagen in the chick embryos were studied. Histamine content in bones (tibia and femur) and skin markedly increased in the embryos treated with aminoguanidine. Aminoguanidine treatment was followed by a decrease of total collagen and an increase of soluble collagen fraction both in bones and skin. 48/80 did not change the histamine level in the bones but decreased that in the skin. 48/80 administration resulted in an augmentation of the total collagen content in the skin. Both in the skin and bones soluble collagen fraction was found to be lower in 48/80 treated embryos.
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The effects of mepyramine (H1-receptor antagonist), cimetidine (H2-receptor antagonist), IEM-813 (H1-receptor agonist) abd 4-Met-Hi (H2-receptor agonist) on collagenogenesis processes in subcutaneous implanted sponges of rats were studied. Administration into sponges of cimetidine 30 min before histamine injection blocked both the stimulatory effect of low histamine doses and the inhibitory effect of high histamine doses of collagen formation. Low doses of 4-Met-Hi increased collagen levels but reduced the levels at high doses. Mepyramine and IEM-813 did not influence collagen biosynthesis.
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The effect of high doses of histamine (Hi) on collagen and glycosoaminoglycan (GAG) content in skin wounds of rats was studied on days 1, 3, 5, 10 and 14 after wounding. Injection of high doses of Hi into the wounded area inhibited colagen production, collagen polymerization and GAG synthesis; levels of chondroitin sulphates (chondroitin-4,6-sulphate and dermatan sulphate) and hyaluronic acid were decreased.
The effects of compound 48/80, adenosine-5-triphosphate (ATP) and exogenous histamine (Hi) on the healing of excised surface wound and tensile strength of surgical skin wound in rat were studied. The chemicals were injected directly into the wound area. 48/80, ATP and exogenous Hi were found to stimulate the wound healing as measured by collagen formation, tensile strength examination and a measurement of the surface circular wound. When given separately, the order of activities was: 48/80 is greater than ATP is greater than Hi; when administered together as a mixture, compound 48/80, ATP and exogenous Hi also accelerated the wound healing. The mixture shortened the healing process by about 5 days as compared with 17 days in control.
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