[Mucosal and dental changes in bullous polydysplastic epidermolysis].
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Biomedical subjects
Publications and source records attributed to R Deli.
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Tetracycline labelling was employed to assess pulp and dentin reactivity to the use of oxyphosphate cement in the dog. A comparison was made of dentine conditions below control cavities and those containing the cement. In the former, the pulp and dentin response consisted of enhanced dentinogenesis, whereas in the latter this parameter showed no particular changes throughout the experimental period.
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The literature on oral exfoliative cytology in the diagnosis of malignant lesions is reviewed and the techniques most commonly employed for the removal of material, fixing, staining and observation are described, along with the usual diagnostic criteria. Evaluation of prior comparative cytological and histological assessments of the diagnostic reliability of the means is followed by an account of the difficulties encountered when comparing results so as to form a final opinion on its possible applications. It is felt that, while exfoliative cytology cannot take the place of biopsy in making a definite assessment of the nature of a lesion, the literature shows that it is widely applied in addition of clinical evaluation of oral lesions.
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The Authors have proposed to develop this research employing a preparation containing exclusively a cortisonic, the desametazone, in order to evaluate the alterations of the dentinogenesis to be attributed to such component. 32 cavities have been carefully drilled in dogs' cuspids. The 16 experimental cavities were dressed with desametazone, asbestos and amalgam in successive strata while in the 16 control cavities only asbestos and amalgam were used. Stainless steel bands were cemented on the processed teeth. The animals received 9 I.V. injections of tetracycline (10 mg per kg) each at 7 days interval. In the observation of the tetracycline markings under the experimental cavities (with desametazone) alterations of the dentinogenesis were not observed. Consequently, it seems that the action of desametazone is not to be considered harmful for the pulp tissue under the freshly cut dentine, as far as duration of the experiment is concerned.
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Odontomix (reg'd) cement was used at the bottom of cavities prepared in healthy dog canines in a attempt to prevent pulp and dentine alterations caused by the preparation and filling of cavities. 24 dogs were used along with 24 controls. I.v. tetracycline was afterwards given 10 times at weekly intervals. Examination of tetracycline labelling under the cavities showed that the cement caused pulp and dentine changes in confined areas, though it has not yet been possible to determine whether these are due to the corticosteroid, the antibiotic, or the excipient employed in the preparation.