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Biomedical subjects

R Derache

Publications and source records attributed to R Derache.

At least 55 records · Page 3Linked to original sources
PubMed1977

Tannic acid and oxidized tannic acid on the functional state of rat intestinal epithelium.

Diets containing tannic acid at the level of 3% of dry matter were fed to rats in order to ascertain the origin of fecal nitrogen and the effect of tannic acid on the intestinal mucosa. At the same time in order to explain the effect of oxidation of tannins, we administered diets containing oxidized tannic acid or tannic acid associated with an antioxidizer (sodium sulfite) at the level of 1% of dry matter. The increased excretion of sialic acid and glucosamine during ingestion of tannic acid indicated that the excess of fecal nitrogen mainly corresponds to the mucus hypersecretion observed by histology. Fecal analysis revealed perturbations in movements of water and ions. The study of the metabolic activity of isolated enterocytes and the activity of some enzymes in a homogenate of these cells showed an inhibition of oxygen consumption and succinic dehydrogenase activity. Addition of reducing agent (sodium sulfite) to the diet had little effect on the action of tannic acid; but previous oxidation of the tannin reduced the effects observed, particularly in the case of fecal nitrogen loss.

Animals↗
PubMed1976

[Availability of 14C-carbaryl after oral intake by pregnant rats].

After a single per os administration of an anticholinesterasic drug, 1-naphthyl-N-methyl 14C-carbamate to the pregnant Rat (18th day) we determine 14C activity from blood, liver, kidney, spleen, lung, brain, heart, placenta and foetus at intervals between 1 and 96 hrs. We compare membranous transfer of carbaryl metabolites. Hemato-encephalic diffusion is slow. Intestine and placental transfers are effective from the 1st hr. and of important value.

Administration, Oral↗
PubMed1976

[Variations in circulating bradykinin and its precursor during treatment with ethanol and disulfiram in the dog].

Blood variations of bradykininogen and bradykinin have been measured in the Dog after single or combined treatments with ethanol and disulfiram. Ethanol only induces hyperbradykinnemia and chronic disulfiram decreases plasmatic level of bradykinnogen without modifying bradykinn. During associated treatment disulfiram-ethanol, physiological disturbances are observed in bradykinin formation; these disturbances can explain partly vasomotor reaction following treatments.

Animals↗
PubMed1976

[Influence of a low-protein diet on the acute toxicity of a pesticide: Nabam].

Male rats are fed during twenty eight days from the weaning with semi-synthetic isocaloric diets containing 3,5 p. 100 and 26 p. 100 of proteins under the from of casein and with a standard laboratory diet. At the end of this period the LD50 and the pathological clinical syndrome of a fungicid belonging to the dithiocarbamate series : the Nabame, are determined in each of the groups of rats receiving their respective diet. The LD50 is significantly reduced among the rats with a deficiency in proteins compared with the LD50 determined among the two other groups of animals. A likely explanation is to be looked for, at least for a part, on the level of the production or of the activity of detoxicating microsomal hepatic enzymes which the restrictions of nitrogen supply could reduce. The pathological - clinical syndrome of toxicity : stimulation then depression of the central nervous system, severe inflammation of the gastro-intestinal tract, important renal necrosis, is essentially the same among all the animals and it does not seem to be influenced by the level or nature of the proteinic supply.

Adrenal Glands↗
PubMed1976

[Nutritional effects in the rat of oxythioquinox (morestan) as a function of its concentration and of the lipid content of the diet].

Of two groups of rats, one received a normal diet and the other a high fat diet for 5 weeks. The effects of oxythioquinox, administred at diet concentration of 200, 400 and 800 mg/kg, of fresh food are studied on weight gain, food and calorie intake and on the weight and composition of various organs. Growth, food and calorie intake are diminished in relation to oxythioquinox concentration in the diet. There exist an interaction between the fat content of the diet and the toxicity of oxythioquinox. The decrease of the efficiency of calorie by oxythioquinox indicates a perturbation of the rats metabolism. An increase in the weight of the liver is observed with a significant interaction between the fat concentration and the oxythioquinox with the results expressed in weight of organ per 100 g body weight. There is an increase in the degree of the water content of the animals liver with normal fat diet. In the case of a high fat diet there is an increase of cholesterol and fatty acid content. In all case, the variations are more strongly marked in relation to the oxythioquinox concentration of the diet and at the same concentration, the high fat diet is more effective that the normal diet. There is an interaction between the lipids in the diet and the oxythioquinox and this interaction indicates, an accentuation of the effects of oxythioquinox by lipids of the diet.

Animals↗
PubMed1976

Secretion and irrigation of gastric mucosa during disulfiram effect. Experimental study in the dog.

The effect of ethyl alcohol and disulfiram (Antabuse) on the secretion and the irrigation of an isolated and denervated gastric pouch has been studied in the dog. In these conditions, disulfiram increased the differential acidity; the association of ethanol with disulfiram impaired the proteolytic activity of the secretion and induced a hyperirrigation of the gastric mucosa more definite than with ethanol alone. Effects on ethanol absorption from stomach are discussed.

Animals↗
PubMed1976

[Digestive absorption, fixation and excretion of oral disulfiram in the rat].

Absorption, distribution and excretion of disulfiram and of one of its metabolites, diethyldithiocarbamate, were studied in rats orally treated with disulfiram (25 or 250 mg/kg). It was noted that this compound is absorbed in a proportion of 70-90 per cent of the administered dose but that diethyldithiocarbamate can appear already in the gut. After absorption, disulfiram and diethyldithiocarbamate impregnate specifically some tissues such as liver, kidney and muscle; blood and brain contain little or no disulfiram. The largest dose of disulfiram decreases fecal bolus and increases urinary volume favouring perhaps excretion of diethyldithiocarbamate.

Administration, Oral↗
PubMed1976

[Metabolism of nitrates-nitrites].

Once the pair nitrate-nitrite--in quantity respectively set by the ingestion level or transformation level by intestinal bacteria--has entered through the intestinal mucosa, it may react with active biochemical groups. Nitrite, owing to its high oxido-reduction potential, may induce the oxidation of a large number of compounds, as for example the Fe++ heme-Fe+++ hemine system, reduced cytochromes-oxidized cytochromes system, etc. If the presence of nitrite in blood is not clearly established, this is due to the nitrite high chemical reactivity. Moreover, a transformation by the tissues of nitrates into nitrites after a nitro-reduction is quite possible.

Amines↗
PubMed1975

[Gastric irrigation and secretion in the ligatured or fistuled pylorus rat upon influence of intra-duodenal olive oil (author's transl)].

Pylorus ligature hides the inhibitory effects of endogenous cholecystokinine-pancreozyme (CCK-PZ) on gastric mucosal secretion and irrigation, whereas the juice collected through transduodenal pyloric fistula makes this phenomenon obvious. It appears that the pyloric fistula encourages inhibition of gastrinic secretion, so that the CCK-PZ can achieve its effects.

Animals↗
PubMed1975

Effects of ethanol on the secretion and mucosal blood flow of a denervated gastric pouch in the dog.

Mucosal secretion and blood flow of a Heidenhain pouch were measured in dogs after orally administered ethanol at doses from 0.25 to 2 g/kg of body weight. Under these conditions, the volume, free and total acidity of the gastric juice as well as mucosal blood flow increased linearly with the dose up to 1 g/kg. In all cases volume secreted and acidity chanm the other parameters and could not be correlated with blood flow. The influence of gastrin and the modification of membrane permeability are discussed with regard to these data.

Animals↗
PubMed1975

[Disulfiram and digestive motility; effect on absorption of ethanol in the rat].

The influence of disulfiram, ethanol and the association disulfiram-ethanol on gastro-intestinal motility and ethanol absorption was studied in rats. It was observed that disulfiram (25 mg/kg) and ethanol (0,8 g/kg), separately administered, decrease gastric emptying a nd increase propulsion in the small intestine; association of the two treatments results in the addition of the particular effects, except in the first intestinal segment. Disulfiram reduces ethanol absorption; very significant correlations have been noted between gastric emptying and ethanol absorption.

Animals↗