[22d International Congress on Pathophysiology of Pregnancy, Budapest, 21-23 June 1990].
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Female↗
Biomedical subjects
R During
Publications and source records attributed to R During.
[Factor VIII-associated antigen/factor VIII ratio in pregnant patients with and without hypertension].
During pregnancy there is an elevation of factor VIII. In hypertensive pregnancy this increase may be smaller. On the other hand factor VIII associated antigen-factor VIII-ratio is said to be increased in these women compared with normotensive ones. There is a discussions about using these change for early detection of PIH. Estimations of factor VIII have been made chemically. Estimations of factor VIII associated antigen have been carried out immunologically. Factor VIII associated antigen-factor VIII-ratio was higher in pregnant women with hypertension than in normotensive ones.
Adolescent↗
[Tocolysis with ethanol--effects on the ethanol content of the blood in the mother and neonate].
In 10 pregnant women infusions with fructose and ethanol have been performed during labour until delivery. Ethanol concentration in blood have been estimated during delivery and in the post partum period. A decrease of labour activity could be found already with ethanol blood level below 0.5 mg/g. Ethanol elimination in newborn was delayed about 30 per cent in comparison with their mothers. We couldn't observe any risk neither fetal nor maternal by ethanol infusion.
Adult↗
[Antithrombin III level in normal pregnancy and patients with pregnancy-induced hypertension].
During pregnancy an increase of antithrombin III can be observed. In hypertensive pregnant women this increase may be smaller. This fact may be a sign of hypertension induced disseminated intravascular coagulation and important for prognosis and therapy of pregnancy-induced hypertension. We carried out estimations of antithrombin III by double determinations using radial immundiffusion. Antithrombin III levels were lower in patient with pregnancy-induced hypertension.
Adult↗
[Treatment of fetal hemolytic disease using plasmapheresis].
Report about the therapy of severe Morbus haemolyticus fetalis in 15 pregnant women by plasmapheresis alone. Fetal survival rate was 67%. One of three children with hydrops fetalis survived. Plasmapheresis may be used in combination with intrauterine transfusion and improves treatment of Morbus haemolyticus fetalis.
Erythroblastosis, Fetal↗
[Intrauterine intraperitoneal transfusion controlled by ultrasound. A case report].
Two intrauterine transfusions in one fetus have been performed utilizing continuous ultrasound supervision by Sonolayer SSA-90 A in the 31st and 33rd gestational week.
Adult↗
[Results of prenatal amniotic fluid diagnosis in suspected hemolytic disease of newborn].
759 amniotic fluid samples have been examined spectrophotometrically according to Liley and chemically for bilirubin from 286 patients with suspicion of morbus haemolyticus fetalis. The results obtained, gave the following findings for the procedure of Liley: sensitivity 75.0 per cent, specivity 96.5 per cent, accuracy 85.3 per cent, predictive value of positive test 95.6 per cent and predictive value of negative test 79.1 per cent and for the chemical test respectively: 88.2 per cent, 81.7 per cent, 85.0 per cent, 83.0 per cent and 87.2 per cent. A pathological delta E value is suspect of a serious erythroblastosis. But a serious morbus haemolyticus fetalis may be excluded with higher likelihood by concentration of bilirubin chemically determined below the pathological range then by correlated values of delta E. Finally we conclude that two different methods for amniotic fluid diagnostic are of higher predictability.
Amniocentesis↗
[Report of experiences in 20 years use of intrauterine fetal transfusion in severe Rh-induced hemolytic disease of newborn].
136 intrauterine transfusions in 90 fetuses between the 25th and 34th gestational week with severe hemolytic disease because of Rh-incompatibility have been performed after a prenatal step by step diagnostic in the years 1967 till 1986. The reason of the immunization was mistransfusion or omitted immune prophylaxis in 25 cases. 25 from 67 live born children died. There were 23 still births. 34 from 43 fetuses without hydrops survived, but only 8 from 47 fetuses with hydrops. The survival rate over all was 46.7 per cent.
Blood Transfusion, Intrauterine↗
[Comparison of the effectiveness of Partusisten and ethanol tocolysis. I: long-term tocolysis with Partusisten or ethanol].
Effectiveness of long term tocolysis with fenoterol (Partusisten) (n = 124) or ethanol (n = 117) has been compared in a retrospective study of the years 1978 to 1980. Situation of starting therapy has been estimated by Bishop-Score, tocolysis index and gestational week. Criterias of success were duration of gestation (reaching greater than or equal to 37th gestational week), neonatal parameters (weight greater than or equal to 2500 g, RDS morbidity, neonatal mortality) and prolongation index by Richter and success score by Weidinger. Fenoterol (Partusisten) is the better drug for treatment of premature labor. In cases of contraindications or incompatibility ethanol tocolysis is justified.
Adult↗
[Comparison of the effectiveness of Partusisten and ethanol tocolysis. III: Comparison of long-term and short-term tocolysis with Partusisten and ethanol].
The effectivity of Partusisten or ethanol long term respectively short term tocolysis by combination of a retrospective and a prospective-randomised study has been compared. Long term tocolysis was better than short term tocolysis. Partusisten was more effective than ethanol. Partusisten long term tocolysis was different to other forms or treatment with a high significance. 70% of newborns after Partusisten long term tocolysis had a birth weight of 2500 g or more.
Birth Weight↗
[Comparison of the effectiveness of Partusisten and ethanol tocolysis. II. Short-term tocolysis with Partusisten or ethanol].
A prospectively randomised study for treatment of premature labor either by Partusisten or ethanol short term tocolysis was done in the years 1981 to 1983. The tocolysis was successful in 54 per cent (Partusisten) respectively 50 per cent (ethanol) by reaching a birth weight 2,500 g. 36 per cent respectively 37 per cent pregnant women reached 37th gestational week. Prolongation index 21 or more allows to predict a birth weight of 2,500 g or more. Success score 12 is not identical with corresponding birth weight. Ethanol tocolysis is an alternative to Partusisten treatment.
Adult↗
[Experiences with the use of sulprostone (Nalador) for the termination of pregnancy in the 1st trimester in primigravidae].
Sulprostone in different doses and application forms (25, 50 or 100 micrograms extra-amnionic; 500 micrograms or 3 times 500 micrograms every 4 hours intramuscularly) was given to perform termination of pregnancy between 7th and 12th week. The dose of 500 micrograms three times given was most effectiveness, but there were the most side effects, too. The dose of 500 micrograms Sulproston was accompanied by less side effects and the therapeutic success was sufficient. The extra-amnionic application was effective also in all used dosages.
Abortifacient Agents↗
[Comparative coagulation studies in induced therapeutic abortions with prostaglandin].
Therapeutic abortion in the first trimester of pregnancy have been done in ten primigravidae using PGF2 alpha, 15-methyl-PGF2 alpha, or Sulprostone. Bleeding and recalcification time, platelet count, fibrin, platelet adhesiveness, partial thromboplastin time and thromboplastin time were examined before, during and after treatment. We found a decrease of platelet count and a prolongation of bleeding and recalcification time. There was no intensive-influence on coagulation system by the prostaglandin used. Therefore prostaglandins may be used for therapeutic abortion.
Abortifacient Agents↗
[The fight against hemolytic disease of the newborn-- an example of interdisciplinary cooperation].
The practical proceeding used in checking anti-D-immunoprophylaxis, in monitoring carriers of antibodies during gravidity and in treating newborns is represented. Details of patients selecting by means of step by step prenatal diagnostics as well as technique and results of intrauterine transfusion are described. After the general introduction of anti-D-prophylaxis, the morbidity resulting from morbus haemolyticus could be reduced by 80% approximately. The survival rate of foeti intrauterinely transfused amounts to 49%.
Blood Transfusion, Intrauterine↗
[Value of the oral glucose tolerance test for diagnosis of intrauterine fetal retardation].
Oral glucose tolerance test using 50 g glucose has been done in 76 pregnant women. The newborns were subdivided in 3 groups: under the 5., under the 10. and above the 10. weight percentile. The glucose tolerance test had no predictive value for the diagnosis of intrauterine growth retardation.
Adult↗
[Therapy of cervix insufficiency--cerclage or support pessary?].
To evaluate the efficiency of cerclage or pessary a prospective random study has been done from 1982 to 1983. Pelvic score of Bishop and tocolysis index of Baumgarten were used to define the situation at the beginning. Success has been estimated with help of neonatal parameters (birth weight, Apgar score and RDS-morbidity) and final gestational week. Both methods are equal in their effects.
Adult↗
[Measurement of uteroplacental circulation--methods of determination and clinical evaluation].
Numerous factors influence the rate of transfer of various substances across the placental barrier between mother and fetus. Placental metabolism is of eminent importance. The metabolic exchange capacity is dependent decisively from placental blood flow. Different methods have been tested measuring uteroplacental blood supply, but for clinical purpose only isotope techniques are suitable.
Cervix Uteri↗
[Determination of zinc, copper and magnesium in the umbilical cord blood of hypotrophic newborn infants].
We determined copper, zinc and magnesium in 19 retarded and 21 normotropic newborns and there mothers in the cord blood serum and in the maternal serum. The content of magnesium in cord blood and the content of zinc in the maternal serum were significantly different in both groups.
Copper↗