[Use of betamimetics in performing cervical cerclage].
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Biomedical subjects
Publications and source records attributed to R During.
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Reported about synthesis, composition and function of surfactant. Because of the importance of functional lung maturity for fetal survival the prenatal prophylaxis of RDS has a great importance. Glucocorticoid treatment is recommended in view of the success and without alternative the.
In addition to a previous paper [7] a survey is given of acute viral hepatitis, drug-induced liver-disease, chronic hepatitis, cirrhosis of the liver, hyperbilirubinemia, hepatic porphyria, and obstructive jaundice as hepatobiliary diseases independent of pregnancy. Finally, some questions of treatment of pregnant women suffering from liver disease are stressed.
Forty-three patients hospitalised for chronic hypertension or superimposed toxemia in late pregnancy were treated with Dopegyt-orally in constant dosage. Blood pressure dropped at the beginning of therapy. In the further course of treatment blood pressure re-increased in 14 patients, that other antihypertensive drugs had to be administered additionally. alpha-methyldopa alone is sufficient only in a part of the hypertensive patients.
From 1976 to 1980 we treated 875 women with signs of toxemia of pregnancy. Preeclampsia was diagnosed in the majority of patients. The frequency of eclampsia was 0.23%. Distribution of ages was the same as well in the toxemic patients as in the whole number of deliveries. Nulliparity was overrepresented in toxemic women. The number of operative deliveries and the ratio of retarded newborns was higher compared with all deliveries.
Report on the findings of 353 hypertensive pregnant women during hospitalization. We found only a slight decrease of body weight and blood pressure. Drugs were given on 214 patients. In 20,7% of all cases we found anemia. The level of serum creatinine was increased in 95% of the patients. The hormone and enzyme diagnostics did not correlate to the severity of hypertensive disorders.
We carried out a tocolysis in 14 women with and in 13 women without magnesium and determined the magnesium level in maternal and cord serum. The magnesium determination could not give a declaration about the role of magnesium in diagnostic and therapy of preterm delivery.
In its introduction, this review deals with the influence of normal pregnancy on the liver. Then, intrahepatic cholestasis of pregnancy and acute fatty liver of pregnancy as diseases peculiar to pregnancy are considered intensively. A second part will be dedicated to liver diseases independent of pregnancy.
We determined zinc, magnesium and copper in amniotic fluid of 10 women with retarded newborns and 15 women with normweight newborns. The values in both groups were not significantly different.
Clot determinations were done in plasma and in a mixture of amniotic fluid and plasma in relation 1:1 in 74 patients with toxemia of pregnancy and in 40 normal late pregnant women. Recalcification time was shortened. The activity of the factors of prothrobin complex was detectable in all normal and toxemic patients. Activity of factor V could be detected only in a few cases, plasminogen could not be deceted in the two groups. Clotting activity was stronger in patients with toxemia than in normal pregnant women.
A case of intrauterine fetal growth retardation with polycythemia is reported on a newborn whose mother was treated five years before pregnancy by an artificial external fixed-rate pacemaker because of complete atrioventricular block with right bundle-branch block and Adams-Stokes syndrome. Obviously fixed-rate pacemaker does not meet all necessities of pregnancy. Therefore in young women who wish to have children only demand pacemaker with programmable frequency are supposed to be used. They may be better for the requirements of systemic and uterine circulation in pregnancy.
Maternal blood pressures as well as maternal and foetal heart rates following intravenous injection of 300 mg diazoxide (Hypertonalum) were recorded from six hypertensive women in labour. Drop in blood pressure was accompanied by rise in both maternal and foetal heart rates. Diazoxide (Hypertonalum) can be recommended for therapeutic application to patients with acute hypertensive crisis.
The effects of one single intravenous injection of 5 mg of nylidrin, following administration of 113m-indium, on utero-placental blood supply were studied in 23 women in advanced pregnancy, all of them afflicted with hypertension. Pulse rates over the placenta rose in 16 cases, primarily in patients from which prolonged half-life was measured.
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In 15 pregnant women of the first trimenon of gravidity an interruption was performed by means of extra-amnial application of PGF2a and in 10 pregnant women by means of i. m. application of 15-methyl-PGF2a. Bleeding time, recalcification time, number of thrombocytes, heat fibrin, and thrombocyte adhesiveness were determined before, during and after treatment. Statistically significant changes could be observed during bleeding time, heat fibrin, and thrombocyte number. The investigations of coagulation, however, did not reveal any considerable impairment of the coagulation system, thus confirming the positive evaluation of prostaglandines used for therapeutic induction of abortion.
A dose of 3 g of carnitine was orally administered through 48 hours to six patients, between the 31st and 35th weeks of pregnancy, in a bid to induce foetal lung maturation. The process of foetal lung maturation proper was monitored by transabdominal amniocentesis, prior to and following medication. No increase in surfactants in the amniotic fluid was recordable by means of this method.