Biomedical subjects

R F Dyck

Publications and source records attributed to R F Dyck.

39 records · Page 3Linked to original sources

PubMedDate not supplied

From "thrifty genotype" to "hefty fetal phenotype": the relationship between high birthweight and diabetes in Saskatchewan Registered Indians.

BACKGROUND: Intrauterine factors have been implicated in the pathogenesis of Type 2 diabetes mellitus (T2DM). METHODS: In a 1:1 matched pairs case-control study, high and low birthweight (HBW, LBW) rates in Saskatchewan Registered Indian (RI) diabetic cases were compared with corresponding rates in RI without diabetes, and non-RI people with and without diabetes. RESULTS: Birthweights were available for 73% of the 1,366 cases and 3 x 1,366 controls. A greater proportion of RI diabetics were born with HBW (> 4000 grams) compared to RI non-diabetics (16.2% vs 10.7%; p < 0.01). There was a significant association between HBW (but not LBW [< 2500 grams]) and diabetes for RI people (OR 1.63 [95% CI 1.20, 2.24]), which was stronger for RI females and strengthened progressively from mid to late 20th century. INTERPRETATION: Certain causes of HBW may predispose to subsequent development of T2DM in Canadian Aboriginal people ("hefty fetal phenotype" ["hefty fetal type"] hypothesis). Programs that optimize healthy pregnancies could reduce T2DM incidence in future generations.

Adolescent↗

PubMedDate not supplied

Glomerulonephritis associated with polymyositis.

Five patients with primary idiopathic polymyositis developed proteinuria associated with urine sediment abnormalities. Renal biopsies disclosed a focal mesangial proliferative glomerulonephritis with deposits of immunoglobulin and complement. After treatment of the polymyositis with corticosteroids, proteinuria and urine sediment changes disappeared within 4 to 8 wk along with an improvement in the muscle disease. Although the pathogenesis remains to be determined, immune complexes may be implicated in the etiology of this renal lesion.

Adrenal Cortex Hormones↗

PubMedDate not supplied

Diabetes prevalence rates among First Nations adults on Saskatchewan reserves in 1990: comparison by tribal grouping, geography and with non-First Nations people.

OBJECTIVE: To determine age-specific, sex-specific and total prevalence rates of diabetes mellitus among Saskatchewan First Nations adults and to compare these rates by tribal grouping, geography and with non-First Nations people. DESIGN: A point prevalence study of all Saskatchewan reserves in 1990. RESULTS: Age-adjusted rates of diabetes mellitus were higher (risk ratio 1.8) among First Nations adults (9.7%) than among non-First Nations adults (6.1%). These racial differences were greater between women (12.1 vs 6.6%) than men (7.2 vs 5.6%). First Nations diabetes rates were highest among individuals with Saulteaux and Sioux ancestry, and among those living on southern reserves. CONCLUSIONS: The prevalence of diabetes mellitus among Saskatchewan First Nations people has increased from 0% to almost 10% within the adult population since 1934 and has more than doubled from 1980 to 1990. This epidemic manifests itself to a greater extent among women and certain tribal groups, possibly due to differences in exposure to non-traditional lifestyles.

Adult↗