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Biomedical subjects

R F Macadam

Publications and source records attributed to R F Macadam.

At least 37 records · Page 2Linked to original sources
PubMed1970

Renin and acute renal failure: studies in man.

Plasma renin concentration was increased, usually appreciably, in 22 out of 25 patients with acute renal failure, the average value being 226 units/litre (mean for normal subjects 8.2 units/1.). The highest renin values were found in the first 10 days of the disease; lower and sometimes normal values were found subsequently. Unequivocal acute tubular necrosis was present in only two of the eight cases examined post mortem.These findings are compatible with Goormaghtigh's proposal that an excess of renin and angiotensin may act within the kidney to produce acute renal failure.

Acute Kidney Injury↗
PubMed1970

Glomerular fine structure in mixed membranous and proliferative glomerulonephritis.

A case of mixed membranous and proliferative glomerulonephritis has been studied by light and electron microscopy. Electron microscopy has shown that the cellular proliferation is mesangial in origin and that there are qualitative and quantitative alterations in the filtration basement membrane. In addition there are numerous examples of direct contact between filtration basement membrane and neutrophil polymorphonuclear leucocytes. This latter phenomenon is good direct evidence that interaction of glomerular-bound antigen-antibody complex and complement has taken place. The light and electron microscopic evidence is thus in favour of the histopathological entity, mixed membranous and proliferative glomerulonephritis, being fundamentally a proliferative glomerular lesion initiated by complement-induced basement membrane injury.

Antigen-Antibody Complex↗
PubMed1969

Fine structural evidence for hormone secretion by a human thymic tumour.

An epidermoid type of thymoma from an asymptomatic 39-year-old male subject is described. Electron microscopy demonstrated endocrine type secretory granules within the tumour cells, and a minority of these granules resembled normal human pancreatic alpha cell granules. Fine structural evidence for endocrine secretory activity in a primary thymic tumour has not been previously described. There are few fine structural reports of primary thymic tumours in man and to our knowledge these do not include certain features of the case described here.

Adult↗