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R Farbiszewski

Publications and source records attributed to R Farbiszewski.

At least 109 records · Page 6Linked to original sources
PubMedDate not supplied

Effect of methanol intoxication on free-radical induced protein oxidation.

Oxygen free radicals are generated during methanol-induced liver injury, as was shown for ethanol. The effect of methanol intoxication (6 g kg(-1) body wt.) on protein modification in the liver of rats was investigated. Electron spin resonance determination indicated an increase in the free radical signal 6 and 12 h after intoxication. After 7 days of treatment, the contents of malondialdehyde and carbonyl groups in proteins were significantly increased. The level of amino groups and sulphydryl groups and the amount of tryptophan in proteins were decreased, whereas the amount of bi-tyrosine was increased significantly. Changes in protein structure resulted both from free radical action and formaldehyde generation during methanol intoxication.

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PubMedDate not supplied

The effect of immunostimulatory drugs on sulfhydryl compounds in plasma, liver and brain after ethanol-induced liver injury in rats.

Sulfhydryl compounds in plasma, liver and brain of rats treated with two immunostimulant drugs, isoprinosine and levamisole, after alcoholic liver injury have been investigated. After use of both drugs for 6 days we found partially beneficial effect on the SH-groups in plasma and liver. No changes in nonprotein SH compounds were observed in rat brain after treatment with isoprinosine, levamisole or ethanol. Furthermore, levamisole shortens the time necessary for the return of AlAT activity to normal value.

Animals↗
PubMedDate not supplied

The effect of heparegen on antioxidant enzyme activities in ethanol-induced liver injury in rats.

SOD, CAT, GSH-Px, and sulfhydryl compounds MDA contents in liver of rats treated with heparegen for 7, 14, and 21 days after alcoholic liver injury have been investigated. After use of this drug, we found beneficial effects on GSH-Px activity, sulfhydryl compounds (total and nonprotein), and MDA content and a partially beneficial effect on SOD and CAT activities. These enzyme activities after 21 days of drug administration were restored. Furthermore, heparegen shortens the time necessary for the return of AIAT and GGTP to normal value. This enzymatic data are supported by histological studies in light microscopy.

Animals↗