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R Farbiszewski

Publications and source records attributed to R Farbiszewski.

125 records · Page 7Linked to original sources
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Antioxidant status of liver, erythrocytes, and blood serum of rats in acute methanol intoxication.

SOD, CAT, GSH-Px, GSSG-R, ascorbic acid, alpha-tocopherol, nonprotein- and protein-bound sulfhydryl compounds, and TBA-rs content in the liver, erythrocytes, and blood serum of rats treated with methanol after 6, 12, and 24 h and 2, 5, and 7 days were investigated. Furthermore, hematological parameters of erythrocytes were analysed. GSH-Px, GSSG-R, sulfhydryl compounds, and ascorbic acid in the liver, erythrocytes, and in blood serum were significantly decreased. In addition, Cu,Zn-SOD and tocopherol in erythrocytes were diminished, whereas TBA-rs in the three biological materials was enhanced. Simultaneously, erythrocytes amount, hemoglobin level, hematocrit, and MCV were reduced. These results indicate that methanol in rats leads to the impairment of antioxidant mechanisms in the liver, erythrocytes, and blood serum.

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Role of reperfusion with polyelectrolyte solution and BN 52021 in hemorrhagic shock-induced changes in rat lungs.

The aim of this study was to test whether reperfusion with isotonic standard polyelectrolyte solution alone has any influence on the redox balance in the lung during hemorrhagic shock, and whether reperfusion and BN 52021, used together have better protective effect on free radical lung injury. The results showed that reperfusion with electrolyte solution increased solely glutathione reductase activity (GSSG-R), and diminished the activities of Cu,Zn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as the content of SH-groups. Thiobarbituric acid reactive substances (TBA-rs) were much more increased in comparison to hemorrhagic shock. After reperfusion with polyelectrolyte solution and the administration of BN 52021, the antioxidant parameters returned to normal values, while TBA-rs slightly decreased.

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PubMedDate not supplied

The heparin neutralizing activity of venous and polyester aortic grafts.

The distribution and variations of heparin neutralizing substances in venous and polyester grafts in the abdominal aorta of dogs were investigated and the results compared with those of normal arteries and veins. 1, 4 and 36 months after the operation the venous and polyester grafts were excised and dissected into three layers. The antiheparin activity of the different layers was then determined. In the early post-operative period, the antiheparin activity in the venous and polyester grafts is higher but later begins to fall so that its level 3 years after the operation approaches that of the various layers in the normal veins.

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Accumulation of ammonia and changes in the activity of some ammonia metabolizing enzymes during brain ischemia/reperfusion injury in rats.

The ammonia concentration and changes in the activity of ammonia metabolizing enzymes in the brain tissue during ischemia/reperfusion were investigated in rats. During ischemia (0.5 h) we found a statistically significant increase in brain ammonia concentration and a significant decrease in glutamate dehydrogenase activity. After 1 h of reperfusion, a further accumulation of ammonia concentration was observed. Furthermore, the brain glutamine syntethase and glutamate dehydrogenase were decreased, whereas the brain glutaminase activity was increased. The causes for the changed activities of some ammonia metabolizing enzymes in brain after ischemia/reperfusion have been discussed.

Ammonia↗
PubMedDate not supplied

[Participation of free radicals in the mechanism of brain tissue damage].

There is now extensive experimental support for the early occurrence and pathophysiological importance of oxygen radical formation and cell membrane lipid peroxidation in the injured brain tissue. Several criteria for the establishment of the pathophysiological significance of oxygen radicals processes have been met. These include: 1. demonstration of increased posttraumatic levels of oxygen radicals and lipid peroxides soon after CNS injury, 2. the spatial and temporal correlation between oxygen radical formation and pathophysiological alterations (e.g. vasogenic oedema, progressive posttraumatic ischemia development, loss of microvascular autoregulation), 3. the striking similarity between posttraumatic CNS pathology and that caused by chemical peroxidative insult, and 4. the protective efficacy of oxygen radical scavenging agents or compounds that inhibit lipid peroxidation.

Brain↗
PubMedDate not supplied

BN 52021, PAF-receptor antagonist, improves diminished antioxidant defense system of lungs in experimentally induced haemorrhagic shock.

The purpose of our experiments was to determine whether BN 52021, PAF-receptor antagonist, has any influence on the production of reactive oxygen species in the lung induced by haemorrhagic shock. The results showed, that the activities of Cu,Zn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the lung after haemorrhagic shock were decreased in comparison with control and sham groups while the activity of glutathione reductase (GSSG-R) was unchanged. The content of SH-groups was decreased while thiobarbituric acid reacting substances (TBA-rs) after haemorrhagic shock were increased. Infusion of BN 52021 (5.0 mg/kg i.v.) in haemorrhagic animals caused significantly increased activities of Cu,Zn-SOD, GSH-Px, GSSG-R in the lung. The SH-group level was slightly increased while TBA-rs returned to normal values.

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