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Biomedical subjects

R Friedman-Birnbaum

Publications and source records attributed to R Friedman-Birnbaum.

At least 91 records · Page 5Linked to original sources
PubMed1985

A direct immunofluorescence study in elastosis perforans serpiginosa.

Two cases of elastosis perforans serpiginosa were studied by direct immunofluorescence. In one case, homogeneous deposits of IgM, C3 and C4 on the abnormal elastic fibres in the papillary dermis were demonstrated. In addition, in both cases, along the basement membrane zone, coarse linear deposits of fibrinogen and properdin were observed inside and near the transepidermal channels. Groups of cytoid bodies stained for IgM and occasional weak linear deposits of IgG, IgA, IgM and C3 were also observed. The immune deposits on the abnormal elastic fibres might indicate antigenic alteration and activation of humoral immunological mechanisms in the process of their elimination. The other findings may reflect a non-specific binding by damaged tissue structures.

Adolescent↗
PubMed1985

Coexistence of Kaposi's sarcoma and angioimmunoblastic lymphadenopathy.

A 66-year-old woman who developed simultaneously angioimmunoblastic lymphadenopathy (AILD) and Kaposi's sarcoma (KS) is reported. A parallel course of the two diseases was evident. After a relatively short course of corticosteroid therapy, the clinical and laboratory signs of AILD regressed, and the patient is in remission 39 months after the beginning of the disease. At the same time a regression of KS lesions was also observed. The frequent association of KS and lymphoproliferative disorders in the same patient is discussed. As AILD is a lymphoma-like syndrome, it is suggested that we might expect a more frequent association of this disease with KS in the same patient than the two cases reported to date.

Aged↗
PubMed1985

Calcitriol-resistant rickets with alopecia.

Four children of two kindred had alopecia associated with severe rickets, resistant to treatment, and caused by defective cytoplasmic and nuclear receptors for the active vitamin D metabolite calcitriol (1,25-dihydroxyvitamin D3). Scalp biopsy specimen revealed a normal number and light microscopic features of the hair and hair follicles. Calcitriol-resistant rickets should be added to the list of inherited disorders of hair growth, and the association of rickets with alopecia needs to be considered in the differential diagnosis of hair loss.

Alopecia↗
PubMed1984

Epidermal Langerhans' cells in Behçet's disease.

Langerhans' cells were studied in the epidermis of two patients with active Behçet's disease and compared with those in two normal controls. Ultrastructural morphology and the percentage of Langerhans' cells found were similar in patients' (1.88%) and the control epidermis (1.79%). The density of Langerhans' cells in adjacent sites of the same epidermis was not homogeneous, being in the range of 0.8-2.8% in Behçet's disease and 0.6-4% in the controls. In the controls, Langerhans' cells were distributed unevenly. Some were located near the basal layer of the epidermis while the rest were in the mid and upper layers. In Behçet's disease most Langerhans' cells were in the mid-epidermis, but some were immediately beneath the stratum granulosum. In the Behçet's disease epidermis the area occupied by Langerhans' cells was increased by about 25% and the number of granules found increased by about 44%. It is suggested that in Behçet's disease the Langerhans' cells are in a more active state.

Adolescent↗
PubMed1983

Familial occurrence of Kaposi's sarcoma. Report of two brothers.

The racial and geographical distribution of Kaposi's sarcoma is well recognized. Therefore, a hereditary factor is suspected to play a role in it's etiology. Inspite of this, only about 15 instances of familial cases with the disease have been as yet reported in the literature. We describe here an additional instance of Kaposi's sarcoma occurring in two Jewish brothers born in Rumania and we resume the literature on previous reports of familial occurrence of Kaposi's sarcoma.

Aged↗
PubMed1983

Leukocyte inhibitory factor (LIF) in granuloma annulare: a comparative study between the generalized and the localized types.

Leukocyte inhibitory factor (LIF) was investigated in 9 patients with localized granuloma annulare and 8 patients with the generalized form of the disease. The control group consisted of 10 matched, apparently healthy subjects. LIF values were significantly higher in patients with granuloma annulare of both groups than in controls (p less than 0.05 and 0.01). However, no significant difference was revealed between the two groups of patients. Though the results seem to speak for a cell-mediated immune response in granuloma annulare, they do not add a further support to the previously demonstrated differences between the two forms of granuloma annulare.

Adult↗
PubMed1982

Histocompatibility antigens in viral warts.

One hundred patients with viral warts and 108 apparently healthy matched controls were typed for HLA-A and B antigens. No significant difference in the frequencies of antigens was revealed, which suggested that a possible genetic trend in warts is at least not related to A and B loci of the histocompatibility system.

Adolescent↗