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R G Marsanico

Publications and source records attributed to R G Marsanico.

6 recordsLinked to original sources
PubMed1975

Time-dependent changes in amphetamine self-administration following frontal cortex ablations in rats.

Rats were trained to intravenously self-administer d-amphetamine (.01 mg/kg/reward infusion) during daily 1-hr. testing sessions. Following removal of frontal cortex, rates of d-amphetamine self-administration were higher at early (3-5 days) postoperative intervals but lower at later (2-4 wk.) postoperative intervals. These and other results indicated that, as a function of time after surgery, frontal rats are first hyposensitive and then become increasingly hypersensitive to the rewarding effect of d-amphetamine.

Animals↗
PubMed1974

Apomorphine-induced and pilocarpine-induced hypothermia in mice: drug interactions and changes in drug sensitivity after caudate nucleus lesions.

1 Apomorphine and pilocarpine each produced dose-dependent hypothermic effects in mice. However, the dose-response curve for pilocarpine was steeper than that for apomorphine.2 Bilateral lesions of the caudate nucleus produced a permanent decrease in sensitivity to apomorphine but had no effect on sensitivity to pilocarpine.3 Apomorphine and pilocarpine had synergistic effects; i.e. the hypothermic effect was greater following a combination of the drugs than following either drug alone.4 The effect of apomorphine was antagonized by either haloperidol or scopolamine; only scopolamine antagonized the effect of pilocarpine.5 These results suggest that a mechanism involving dopaminergic neurones in the caudate nucleus has a modulatory role in temperature regulation.

Animals↗