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Time-dependent changes in amphetamine self-administration following frontal cortex ablations in rats.

S D Glick·R G Marsanico
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Abstract

Rats were trained to intravenously self-administer d-amphetamine (.01 mg/kg/reward infusion) during daily 1-hr. testing sessions. Following removal of frontal cortex, rates of d-amphetamine self-administration were higher at early (3-5 days) postoperative intervals but lower at later (2-4 wk.) postoperative intervals. These and other results indicated that, as a function of time after surgery, frontal rats are first hyposensitive and then become increasingly hypersensitive to the rewarding effect of d-amphetamine.

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AnimalsCerebral CortexConditioning, ClassicalDextroamphetamineFemaleInjections, IntravenousRatsTime FactorsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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S D Glick, R G Marsanico. 1975. Time-dependent changes in amphetamine self-administration following frontal cortex ablations in rats.. https://doi.org/10.1037/h0076191

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