Effects of cryptands on action potential and on the availability of the fast sodium current in cardiac Purkinje fibres [proceedings].
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Action Potentials↗
Biomedical subjects
R Günther
Publications and source records attributed to R Günther.
Investigations on supercoiled DNA in various rat cells.
The effect of radiation induced single-strand breaks in nuclear DNA and the repair of this damages on the sedimentation properties of nucleoids obtained from rat spleen, rat thymus and rat Yoshida tumour cells was studied. A dose dependent effect of ethidium bromide intercalation on the behaviour of supercoiled DNA could be demonstrated. The repair process of radiation induced single-strand breaks in the DNA of Yoshida tumour cells was delayed in the presence of prostaglandin E2 in the incubation medium. Additionally some in vivo repair experiments were carried out on cells of whole body irradiated rats.
Animals↗
[Percutaneous, transhepatic thrombosis of the coronary vein in the treatment of bleeding oesophageal varices (author's transl)].
Percutaneous, transhepatic catheterisation of the portal vein in order to occlude the gastric coronary vein was carried out in six patients with bleeding oesophageal varices. Bleeding stopped in three patients, but in the other three ceased only temporarily. Complications were one pleural effusion and one haemothorax. At autopsy, marginal portal vein thrombosis was found in two cases. The indication for this procedure is the presence of bleeding from oesophageal varices which cannot be controlled by conservative means in a patient unfit for operation. It provides an opportunity for carrying out a decompression shunt operation in the interva between the bleeds.
Embolization, Therapeutic↗
[Megacaliosis--diagnosis and differential diagnosis (author's transl)].
Megacaliosis is a renal dysplasia which is characterised by rudimentary papillae. The pathogenesis, clinical features and radiological appearances in fire cases are described and the differential diagnosis from other types of calyceal ectasia is discussed, In typical cases the diagnosis of megacaliosis can be made from the excretion urogram. We regard divided renal function studies as essential before making the diagnosis. Where the renal changes are not quite typical, it is necessary to exclude obstructive and inflammatory disease, vesico-ureteric reflux and renal tuberculosis.
Adult↗
[Kidney damage during translumbar aortography treated by selective catheter embolisation (author's transl)].
During a low translumbar aortogram, a kidney was damaged leading to uncontrollable haematuria. The damaged segmental artery was selectively occluded by the injection of butyl-2-cyanoacrylate through a catheter. Bleeding stopped immediately, thereby avoiding a nephrectomy which had been planned. The complications and potential hazards of therapeutic embolisation are discussed.
Aortography↗
[Fine needle puncture for antegrade pyelography and percutaneous nephropyelostomy (author's transl)].
A method for antegrade pyelography and pyelonephrostomy is described using a long, thin needle with a shorter, wider Seldinger cannula. Puncture with a thin needle reduces the risk during antegrade demonstration of the upper urinary tract and can also be used for puncturing collecting systems which are only slightly dilated. When necessary, the Seldinger cannula can be advanced over the needle; subsequently, with the aid of a J-wire, a nephropyelostomy can be performed. The method has been used in 20 patients. In one case of intended bilateral nephropyelostomy the puncture was successful on only one side. There were no serious complications. In only one patient a small perirenal haematoma was found at operation.
Catheterization↗
[Add-on furniture for the dental office].
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Dental Offices↗
[Intraluminal balloon occlusion of the renal artery: clinical applications and observations (author's transl)].
A method permitting percutaneous catheterization and temporary balloon occlusion of the human renal artery with a 5-F-Swan-Ganz-Catheter is presented. When properly performed, the arterial occlusion is reliable, low in complications, and less traumatizing to the vessel than external clamp occlusion. The technique was employed in 112 patients for occlusion of the renal artery prior to tumor nephrectomy, for attaining stop-flow conditions for improved nephrophlebography, for preventing the reflux of emboli at transarterial embolisation of inoperable kidney tumors, or, combined with simultaneous hypothermic perfusion via the second lumen of the catheter, in extensive kidney surgery necessitating ischemia. Particularly this last range of application offers new possibilities for in-situ surgery of the kidney, as it renders dissection of the renal pedicle and cumbersome surface cooling of the kidney unnecessary.
Adenocarcinoma↗
'Diagnostic overkill?' An analysis of 88 negative renal angiograms.
11.3% of 776 renal angiograms evaluated retrospectively displayed normal findings. The main reasons which had led to the misuse of angiography in our cases were: technically poor urograms, incorrect interpretation of anatomical variations and the lack of other examinations associated with the urogram. A diagnostic plan including all less invasive and dangerous procedures is proposed placing sonography in central position.
Evaluation Studies as Topic↗
[Radiation in inflammatory diseases of the hand (author's transl)].
Pyogenic infections endanger the function of the hand. X-ray therapy beginning as early as possible has a good effect. From 1960 to 1975 170 inpatients and 250 outpatients were treated in this way. It has to be emphasized that surgical therapy cannot be replaced by X-ray therapy, but early radiation helps to keep disfunction (handruins) low.
Ambulatory Care↗
[Sclerosing of bleeding oesophageal varices (author's transl)].
Bleeding from oesophageal varices was stopped in two patients by percutaneous transhepatic transportal injection of 50% glucose and thrombin into the gastric coronary vein and the gastro-oesophageal varices draining into it. The only complication was a right-sided pleural effusion in one of the patients.
Esophageal and Gastric Varices↗
[The implementation of a computerized documentation system for the evaluation of spa therapy in patients with rheumatoid arthritis (author's transl)].
A previously-described documentation system for articular examination was applied to evaluate the results of spa treatment in 20 patients with rheumatoid arthritis during 3 separate treatment periods. Physical joint findings were documented and indices were compiled by means of a computer before, during and after treatment with thermal water the first year, normal water the second year (or vice versa) and without baths at all in the third year. These indices were compared statistically. Each kind of treatment produced a statistically-significant improvement in the disease, there being no significant difference in the results achieved by the 3 therapeutic regimens.
Arthritis, Rheumatoid↗
[Balneotherapy of rheumatic diseases (proceedings)].
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Arthritis, Rheumatoid↗
[Current status of preoperative localization in primary hyperparathyroidism (author's transl)].
Since Seldinger demonstrated in 1953 parathyroid adenomas by arteriography, numerous localizing procedures have been advocated. Based on our experience with selective venous sampling for measurement of parathyroid hormone by radioimmunoassay, selective arteriography, pneumomediastinography and scanning with 75Se-selenomethionine, a survey on localization techniques used up to now is given and their value and applications are discussed. Preoperative localization of parathyroid tissue should be limited to patients with previous unsuccessful surgery. In these cases we perform selective venous sampling following selective arteriography for demonstration of the venous drainage pattern and subsequent venous catheterization. Pneumomediastinography is recommended in suspected mediastinal parathyroid adenoma. Scanning with 75Se-selenomethionine is not in use because of its limited success.
Adenoma↗
A simple method for in situ preservation of the ischemic kidney during renal surgery.
A simple method combining the advantages of intraluminal occlusion of the renal artery with hypothermic perfusion of the ischemic organ is presented. Using a double-lumen, balloon-tipped catheter, which is introduced from the periphery, the kidney can be rendered ischemic and can be perfused simultaneously. Initial, hypothermic perfusion and subsequent arrangement on the surface of the open wound effectively protected canine kidneys against ischemic injury over 2 hr of ischemia.
Animals↗
[Transvenous cholangiography in the differential diagnosis of biliary stasis (author's transl)].
Transvenous cholangiography is an alternative to the direct puncture of the biliary tract. It was successfully performed in 13 of 21 patients of a personal series. The method does not require stand-by facilities for operation and is suitable for differentiating intra- from extrahepatic causes of biliary stasis, as well as for the demonstration of cause and localization of obstructive jaundice. Subcapsular liver haematoma with a rupture into the peritoneal cavity and bilihaemia were the main complications (one case of the former). The procedure is contraindicated in acute cholangitis and after cholangitic episodes.
Acute Disease↗
[Echinococcus multilocularis causing extensive biliary obstruction (author's transl)].
Infection of man by Echinococcus multilocularis occurs relatively seldom, most commonly localizing in the liver in the manner of a malignant tumour. A case of alveolar hydatid disease is reported presenting with extensive biliary obstruction, and a large cavitation in the liver due to necrosis. A review of epidemiology, clinical and roentgenological findings is given.
Celiac Artery↗
[Retrograde renal phlebography with balloon occlusion of the renal artery. Technique and scope of a new method (author's transl)].
A new method of retrograde phlebography of the kidney is described; it is carried out by using a balloon catheter in the renal artery for occluding the circulation. The procedure has been carried out in 13 patients without complication. Early experience has provided very good results in the diagnosis of malignant renal tumours; invasion into the venous system can be demonstrated radiologically. In particular, in cases of carcinoma of the renal pelvis, this method represents a significant improvement of the hitherto unsatisfactory angiographic techniques.
Abdominal Injuries↗