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Biomedical subjects

R Gerner

Publications and source records attributed to R Gerner.

At least 19 recordsLinked to original sources
PubMed1989

Neurotensin-like immunoreactivity in cerebrospinal fluid of patients with schizophrenia, depression, anorexia nervosa-bulimia, and premenstrual syndrome.

Neurotensin (NT) concentrations in cerebrospinal fluid (CSF) were measured by a sensitive and specific radioimmunoassay in psychiatric patients and age- and sex-matched normal controls. No increase in CSF NT concentrations was observed after antipsychotic drug treatment. CSF NT concentrations were significantly lower in one group of schizophrenic subjects. NT concentrations were unaltered in patients with depression, anorexia/bulimia, or premenstrual syndrome, and no rostral-caudal gradient for NT in CSF was evident. NT concentrations were not related to age or sex, and probenecid treatment did not alter CSF NT concentrations. Finally CSF NT concentrations were unaltered in paranoid schizophrenic subjects. These findings confirm and extend previous studies of CSF NT that showed certain patients with schizophrenia, nonparanoid type, have reduced CSF concentrations of this tridecapeptide.

Adult↗
PubMed1979

[Biochemical maturation of organs in the foetus and its induction (author's transl)].

Several biophysical and biochemical changes are prerequisites for the adaptation of the newborn to extrauterine life. Enzyme induction is the mechanism on which this adaptation of metabolism is based. The theoretical fundamentals of enzyme induction are presented, and the perinatal origin of enzymes explained by means of the example of PEP carboxykinase. Among the mose frequent disturbances of the maturing of organs are hyperbilirubinaemias and the respiratory distress syndrome of newborn. The biochemical and physical concepts underlying these disease pattens are explained, and possibilities of enzyme induction and hence acceleration of maturity are shown. On the grounds of clinical experience, enzyme induction appears to be safely established as a membrane prophylaxis.

Adaptation, Physiological↗