37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.

Animals↗

PubMed1977

[Regarding the effect of bromhexine metabolite VII on lecithin synthesis in fetal lungs (author's transl)].

With the help of incorporated amounts of radioactively labeled choline, it was shown that bromhexine metabolite VIII in vivo (10 mg, 5 mg, 1 mg/kg body weight) and in vitro (100 microgram to 0,01 microgram/g fetal lung tissue) does not stimulate lecithin synthesis in fetal lungs of rats.

Ambroxol↗

PubMed1976

[Prenatal membrane syndrome prevention using glucocorticoids].

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Female↗

PubMed1976

[In vivo and in vitro investigations of the effect of decortilen (16-methylenprednisolone) on lecithin synthesis in the fetal lung (author's transl)].

Lecithin synthesis in fetal lungs of the rat over three-fold methylation and over choline and CDP-choline was quantitatively determined via the incorporation rate of marked metabolites. The ability of decortilen to influence both modes of synthesis was investigated. In vivo and in vitro, the glucocorticoid stimulates lecithin formation, which can be as high as 200%, only over choline and CDP-choline.

Animals↗

PubMed1976

[Experimental investigations in regard to the optimal stimulation of lecithin synthesis in the fetal lung via glucocorticoids (author's transl)].

On the basis of curves illustrating the effects of dosage on experimental animals, it was shown that glucocorticoids inhibit as well as stimulate lecithin synthesis in the fetal lung. Equivalent doses of corticoids produce comparable results. It was established that the concentration necessary to produce an optimal stimulation of lecithin synthesis was 0.5 to 2.0 mg/kg body weight.

Animals↗

PubMed1975

[Observations on tumor-associated fibrinolysis in human breast-cancer (author's transl)].

In 30 cases of breast-cancer, including 24 primary cases, the tumor-associted fibrinolysis was investigated using agar plate method. In 60% of the tissue sample fibrinolytic activity was found. No activity could be detected in the remaining 40%. There was evidence of a positive correlation between tumor-associated fibrinolysis and tumor size as well as the rate of axilla metastases. Among the fibrinolytic active cases there was a disproporionate number of adenocarcinoma, whereas in the inactive collective the solid and scirrhous carcinoma prevailed. There was no relation between the tumor-associated fibrinolysis and the percentage of tumor cells in the tissue. The firbinolytic inactive tumors showed a better histopathological adaptation to the surrounding tissue than the active ones. There was less small-cell infiltrate in the stroma of the fibrinolytic active tumors than in the inactive cases. No significant difference was found in the form of growth and the occurence of fibre structure. For clinical assessment a longer period of observation and a larger study are necessary.

Adenocarcinoma↗

PubMed1975

[Biochemical behavior of pyruvate kinase, LDH, isocitrate dehydrogenase and malate dehydrogenase in breast carcinomas].

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Breast↗