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Biomedical subjects

R Goebel

Publications and source records attributed to R Goebel.

At least 37 records · Page 2Linked to original sources
PubMed1978

[The olfactor-genital syndrome (author's transl)].

1. Only FSH was increased after intravenous administration of 0.025 mg of GnRH in 2 female patients suffering from olfacto-genital syndrome. LH-serum-concentrations increased significantly, only when 0.1 mg GnRH was applicated intravenously twice with an interval of one hour.2. The response of hPRL-secretion to 0.2 mg TRH was found normal in both patients. However, when 25 mg chlorpromacine were administered intramuscularly, only one patient responded with an adequate rise of serum-hPRL. 3. One patient became pregnant during treatment with HMG/HCG. The clinical course of pregnancy was quite normal. HPL- and HCG-levels were in the normal, hPRL in the low normal range during pregnancy.

Adult↗
PubMed1978

[Effect of biguanide therapy on lactate metabolism during graded submaximal ergometric testing].

Diabetic patients were subjected to exercise testing before and after a short antidiabetic therapy with phenformin, buformin or metformin. Primarily, changes of lactate and of the acid base balance, were analyzed. After therapy with biguanides all 24 patients had increased lactate levels before and after physical strain. Phenformin showed the greatest influence on the lactate metabolism. Metformin the least.

Biguanides↗
PubMed1978

[Hypophyseal dysfunction and chronic hemodialysis].

65 chronic hemodialysed patients showed a mean elevation of serum prolactin up to 35.5 ng/ml and a mean HGH level of 4.2 ng/ml, whereas TSH was within normal range. The response of the prolactin secretion to TRH was poor in patients with a high basal prolactin level. Patients with amenorrhea showed significantly higher prolactin values than menstruating women. It is assumed, that chronic stress caused the elevation of prolactin and HGH.

Adolescent↗
PubMed1977

[Growth hormone determination in a combined adenohypophyseal stimulation test (author's transl)].

The authors sought the simplest but still reliable method for evaluation of the functional reserve of the anterior lobe of the pituitary gland. The proposed test is stimulation of those various functions by injection of insulin, gonadotropin releasing hormone (LH-RH = GnRH) and thyrotropin releasing hormone (TRH). The test fulfils the clinical requirements. Furthermore it forms a valuable first step for the classification of more scientific problems.

Blood Glucose↗
PubMed1977

[The effect of oral contraceptives on levels of thyroid hormone, blood coagulation and ceruloplasmin (author's transl)].

The effect of various hormonal contraceptives on the thyroid hormone level, plasmatic and thrombocytic coagulation, cholesterol and ceruloplasmin levels and the activity of gamma-glutamyl transpeptidase was investigaged by the changes produced by long term cyclic estrogen-gestagen therapy on the metabolism of the organism. The free thyroxine index and the total cholesterol were within the normal range. The thyroxine binding index at 44% was above the normal level and the mean value was significantly raised. The ceruloplasmin concentration in the serum was also significantly increased. Pointers to a general hypercoagulability could not be ascertained with a statistical significance.

Adolescent↗
PubMed1977

[Thyroxine in an amount of 150 micrograms daily for the prevention of the recurrence of goiter].

24 patients, who had undergone a subtotal thyroidectomy, were given 150 micrograms thyroxine daily for 6 weeks for prevention of goiter recurrency. 14 patients had been included in an earlier reported study using 75 micrograms thyroxine daily. Prior to this trial 10 patients had 100 micrograms thyroxine daily; the 14 above mentioned patients had had no therapy for 4 weeks. A significant decrease of the TSH response to TRH is observed when compared with the prestudy regimen. According to this parameter the incidence of hyperthyroidism is increased and the incidence of euthyroidism and hypothyroidism decreased. 2 patients however remained hypothyroid. The before mentioned hyperthyroid patients had only an abnormal TSH-response and were euthyroid when determined by clinical signs or ETR-values. It is concluded, that the dosage of 150 micrograms thyroxin is indicated in patients when reduction of goiter size is desired or a high demand for thyroid replacement is suspected. This (and every comparable) regimen needs a clinical and biochemical control.

Dose-Response Relationship, Drug↗
PubMed1977

The turnover and conversion to glucose of alanine in newborn and grown dogs.

The extent of transfer of carbon atoms from alanine to glucose was examined in pups and grown dogs. [U-14C]Alanine and [2-3H]glucose were injected intravenously and by using the SAAM-26 program a compartmental model was formulated from the tracer data to quantify the kinetics of the alanine- and glucose-carbon system. A 3-compartment model was necessary to describe the alanine-carbon kinetics. Strict identification of these compartments with physiological counterparts was not possible. The overall transport (turnover) rate of alanine-C was found not to change significantly with age when calculated on the basis of body weight. Carbon atoms from alanine reach glucose by three identifiable pathways of different speed. The kinetics suggest that the different pathways are at least in part due to differences in the metabolism of the three carbon atoms of alanine. In pups less than 11 days of age 45-49% of the carbon atoms leaving the alanine subsystem enter glucose; in adults it was 70%. In young pups 18-19% of glucose-C utilized was derived from alanine-C, whereas in adults, 62%. Accordingly a smaller percentage of carbon atoms utilized as alanine appears in glucose and a smaller percentage of glucose-C is derived from alanine in pups than in grown dogs.

Age Factors↗
PubMed1976

[The importance of liver scanning in pancreatic carcinoma (author's transl)].

One of several liver scans were obtained in 29 patients with carcinoma of the pancreas. Scanning of the liver offers several advantages in cases of suspected carcinoma of the pancreas: (1) It may prove malignancy in jaundiced patients without a detectable primary tumor (frequency carcinoma of the pancreas). (2) It may contribute to the differential diagnosis of jaundice when signs of extrahepatic biliary obstruction or metastases can be seen. (3) It is the least strenuous diagnostic method in seriously ill and old patients who are often in very poor condition; sometimes it can spare the patients a laparotomy.

Aged↗
PubMed1976

[Considerations on the information content of diagnostic tests (author's transl)].

The value of a diagnostic test lies in its ability to support the doctor's efforts to detect a certain disease. The aim is to achieve the highest possible probability that the disease is correctly diagnosed by means of the test. Doctors are not always aware of the extent to which a test can contribute to the final diagnosis. This contribution, the information content of the test, can be calculated by various algebraic manipulations. An example (carcinoembryonic antigen) is given, which demonstrates the significance of certain terms such as true and false positive results or likelihood and, moreover, the application of Baye's theorem.

Bayes Theorem↗
PubMed1976

Evidence for a new intermediate state in the mechanism of (Na+ + K+)-adenosine triphosphatase.

A rapid mixing technique was used to follow the intermediate formation of phosphorylated enzyme and liberation of inorganic phosphate by a microsomal preparation of (Na+ + K+)-ATPase. In the presence of 100 mM Na+,but without added K+, phosphorylation reaches a constant level at a rate which is dependent on ATP concentration. Inorganic phosphate production lags during the inital phase of phosphorylation and then accumulates at a constant rate. These observations favor a scheme in which Pi is liberated as the result of turnover of the phosphorylated enzyme. In the presence of 100 mM Na+ and 2.5 mM K+ phosphate production was resolved into two phases consisting of an initial 'burst' and late steady state phase...

Adenosine Triphosphatases↗