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Biomedical subjects

R Hauser

Publications and source records attributed to R Hauser.

At least 181 records · Page 10Linked to original sources
PubMed1984

[Microbial contamination of ABO antigens in bone tissue].

Fragments of human bones were stored in different media for two years and then expression of the ABO antigens was indicated. Simultaneously, microbiological investigations were performed. In almost all cases, different ABO substances were detected in putrefied and fresh bones taken from the same person. Blood group antigens found in putrefied bones were compared with serological activity of bacterium cultured from these tissues. Attempts were made to remove unspecific reactions. The authors assume that bacteria are responsible for nonspecific serological reactions, not only as a carrier of blood-group-like substances, but also as a source of enzymes responsible for changes in the structure of ABO antigens in putrefied bones.

ABO Blood-Group System↗
PubMed1982

Mechanisms of gastroesophageal reflux in patients with reflux esophagitis.

We evaluated the mechanisms of gastroesophageal reflux in 10 patients with reflux esophagitis and compared the results with findings from 10 controls. The patients had more episodes of reflux (35 +/- 15 in 12 hours, as compared with 9 +/- 8 in the controls) and a lower pressure of the lower esophageal sphincter (13 +/- 8 mm Hg as compared with 29 +/- 9 in the controls) (P less than 0.001). Reflux occurred by three different mechanisms: transient complete relaxation of the lower esophageal sphincter, a transient increase in intra-abdominal pressure, or spontaneous free reflux associated with a low resting pressure of the lower esophageal sphincter. In controls 94 per cent of reflux episodes were caused by transient sphincter sphincter relaxation. In the patients 65 per cent of episodes of reflux accompanied transient sphincter relaxation, 17 per cent accompanied a transient increase in intra-abdominal pressure, and 18 per cent occurred as spontaneous free reflux. The predominant reflux mechanism in individual patients varied: some had normal resting sphincter pressure and reflux that occurred primarily during transient sphincter relaxation, whereas others with low resting sphincter pressures had spontaneous free reflux or reflux that occurred during an increase in intra-abdominal pressure.

Adult↗
PubMed1981

Fabricating moisture chamber spectacles with a sectional facial moulage.

A technique for the construction of acrylic resin moisture chambers has been presented. The utilization of a sectional facial moulage allows for the construction of the chambers to be carried out in the laboratory saving valuable patient contact time. The necessary materials are readily available, and the techniques are common to dental practice.

Eyeglasses↗
PubMed1978

IgM and IgG antibody profiles after immunization of man with a HDCS-vaccine (preliminary communication).

HDCS vaccine was given to 20 healthy, not rabies-exposed people on days 0, 3, 7, 14, 28 and 90. Ten of them received in addition 20 IU/kg of human antirabies immunoglobulin. Vaccine potency in NIH tests was 1.8 (WHO). Most individuals did not show any measurable neutralizing antibody titer on days 3 and 7. On days 14, 28, 90 and 300 the mean of titres was above 1:200; with one exception, no titer was lower than 1:50. The sera of days 14 and 90 were separated on "Sephadex G-200" columns. On day 14 at least 46% of the rabies antibody was found in the IgM fraction, while 15% was recovered from the IgG fraction. On day 90 the proportion recovered from the IgM fraction had decreased to 17%; the IgG antibody had increased to 30% of the titres found in whole serum. Almost no antirabies activity was found in the IgG fractions.

Antibody Formation↗
PubMed1977

[Attempts at postexposure active and passive human rabies immunization].

For several years now in Switzerland, postexposure prophylaxis against rabies has been performed with duck embryo vaccine containing inactivated virus. According to WHO recommendations, 14 consecutive daily injections are given subcutaneously followed by 3 booster injections 10, 20, and 90 days later. In addition, a recently developed human diploid cell vaccine has also become commercially available in Switzerland. This study is concerned with the question whether, by the use of the latter vaccine, sufficient antibody titres can be achieved with a smaller number of injections given at longer intervals. Furthermore, the question was studied whether simultaneous administration of homologous human hyperimmune gamma-globulin together with the first vaccination dose inhibits antibody production. "Vaccin rabique inactivé Mérieux", cultivated on human diploid cells, was injected on days 0, 3, 7, 14, 28, and 90. A group of 10 healthy volunteers received active vaccination only, while another group of 10 volunteers received Rabuman Berna, 20 U/kg, in addition. Antibody titrations were done by means of a neutralization test on monolayer cell cultures. On day 14, antibody titers of at least 1:100 (corresponding to more than 3 IU/ml) were found in both groups. There was no indication of significant inhibition of antibody production as a consequence of the combined active/passive vaccination.

Animals↗