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Biomedical subjects

R Hoigné

Publications and source records attributed to R Hoigné.

At least 55 records · Page 3Linked to original sources
PubMed1982

[Drug side effects as the probable cause of death. Results of the Berne Comprehensive Hospital Drug Monitoring Program].

During the years 1974-1980, 19 of 17,285 inpatients of the divisions of internal medicine of two teaching hospitals showed a probable or definite adverse drug reaction (ADR) which was considered to be a major cause of death. In 7 patients the decisive ADR occurred during the hospital stay. The overall mortality from ADR is 0.040%. For each therapeutic group of drugs the following rate of drug-related death was calculated: for anticoagulants 0.047% (3/6378 inpatients), for cardiac glycosides 0.016% (1/6368), for analgesic/antirheumatic drugs 0.014% (1/7112) and for cytostatic drugs 0.38% (2/531). In 12 patients the ADR was already present on hospital admission.

Aged↗
PubMed1982

[Wernicke-Korsakoff syndrome in anorexia (author's transl)].

A rare case of Wernicke-Korsakoff syndrome due to malnutrition (in a 35-year-old woman) is reported. It was probably the result of a psychiatric condition progressing to severe inanition. In the course of the malnutrition typical Wernicke-Korsakoff syndrome developed. Vitamin B1 deficiency was confirmed by determining erythrocyte transketolase. At the same time there was hypomagnesiaemia; substitution treatment led to complete recovery.

Adult↗
PubMed1980

[Drug fever caused by the antidepressive agent nomifensine (Alival)].

During 1979 4 patients were observed who developed short episodes of fever as high as 104 degrees F after oral intake of 25--100 mg nomifensine (Alival). In all four cases a clear fever spike was produced by reexposure to the drug. The reaction time was 4--6 hours. this drug-induced fever appeared initially 2--4 weeks after the commencement of Alival therapy. No other cause for the fever was identifiable. In one patient an allergic alveolitis was suspected to be a further reaction. In another patient a concomitant granulomatous hepatitis was possibly also due to this drug. It is probable that the febrile reactions have an allergic mechanism. Allergologic investigations have not yet been completed.

Aged↗
PubMed1980

[Early detection and determination of the incidence of side effects in the hospital by intensive (comprehensive) drug monitoring].

In the "Comprehensive Hospital Drug Monitoring Berne" (CHDMB) the frequency of adverse drug reactions can be either determined by counting individual patients with probable or proven reactions to a drug or by mathematic-statistical analysis of exposed and nonexposed patients with and without the reaction. These two methods are used to show the frequency of a maculopapular rash in connection with three antiinfectious drugs. The mathematic-statistical frequency of a maculopapular rash was 11.0% for aminopenicillins, 3.7% for other penicillins, and 3.4% for co-trimoxazole and sulfonamides compared to 1.2% in patients treated with other than the especially mentioned drug groups. Two new adverse reactions were detected by this system: arterial hypotension due to novaminesulfon-dipyrone (Novalgin) and drug fever to the antidepressive drug nomifensin (Alival). Also the frequency of some other, not unusual adverse reactions is demonstrated.

Anti-Infective Agents↗
PubMed1980

On the significance of severe local reactions to Hymenoptera stings.

Of 317 patients with hypersensitivity to Hymenoptera stings forty had severe local reactions (SLR) only, fifty-nine reported severe local reactions before their first and seven after their last systemic reaction (SR). The probability to develop a life threatening systemic reaction when restung after a severe local reaction was calculated to be about 5%. In 80% of the patients with severe local reactions only, hypersensitivity to either bee or yellow jacket venom could be demonstrated by skin tests and/or RAST. A fair correlation of skin test and RAST results was observed. In patients with severe local reactions hyposensitization therapy with venoms is not generally indicated. In exceptional patients whose allergy is proven by skin tests or RAST and who are at a high risk of being restung, hyposensitization may be considered.

Adolescent↗
PubMed1979

Comparison of skin tests and RAST for the diagnosis of bee sting allergy.

Skin tests and estimation of specific IgE-antibodies by the RAST are evaluated as diagnostic procedures in bee sting hypersensitivity with the followiny extracts. (2) With bee venom results of skin tests and RAST correspond in 82%, with bee wholebody extracts in 68%. (3) Both with skin tests and the RAST with bee venom a good discrimination between patients with bee sting hypersensitivity and non-allergic controls is observed. Skin tests with bee venom are somewhat more sensitive than bee venom-RAST. (4) With the careful skin test procedure chosen, no adverse reactions were observed.

Allergens↗
PubMed1979

Immunotherapy in bee sting hypersensitivity. Bee venom versus wholebody extract.

Fifty-six patients with serologically confirmed bee sting hypersensitivity were treated for 1-3 years with either bee venom (BV) (31 patients) or wholebody extract (WBE) (25 per cent of re-exposed patients on BV-therapy showed a diminished reaction and 75% no reaction. Thirty-three per cent of re-exposed patients on WBE-therapy developed an unchanged or worse reaction, 42% a diminished reaction and 25% no reaction at all. An initial rise in BV-specific IgE was observed in BV-treated patients, whereas IgE levels after 1 year of treatment lay significantly below pretreatment values in both treatment groups. BV-specific IgG increased markedly in patients on BV-therapy and decreased slightly in those on WBE-therapy. The initial IgE increase induced by BV-therapy was insignificant in patients with high pretreatment levels of specific IgG-antibodies. Similarly, re-exposed patients with high BV-specific IgG showed no IgE increase, whereas a substantial rise in specific IgE was observed in those with low IgG. On the basis of clinical and serological results immunotherapy with BV is considered to be clearly superior to immunotherpy with WBE.

Adult↗
PubMed1977

[Serologic-nephelometric method for the detection of allergic reactions to small-molecular drugs using polystyrene sodium particles instead of soluble polystyrene sulfonate sodium as pharmaceutic aids].

The previously developed two-step method using soluble polystyrene sulfonate-Na for the detection of allergic reactions to small molecular drugs has been replaced by a one-step method using particles of the same substance. The new method is simpler to perform. Particulate polystyrene sulfonate is commercially available. The drug is added in increasing concentrations to diluted serum samples and the light scattering is measured with a highly sensitive nephelometer. Both the specific serum factor in the patient's serum (globulins) and the non-specific factor contained in most fresh human sera are particularly labile.

Antibody Formation↗
PubMed1976

The frequency of adverse drug reactions as dependent upon age, sex and duration of hospitalization.

In 1972, 171 (18, 7%) of 914 patients showed evidence of an adverse drug reaction (ADR) in a prospective study of the division of internal medicine in a regional teaching hospital (Zieglerspital, Bern). The following factors correlated positively with frequency of ADR: 1. The duration of hospital stay. 2. The age between 60 and 80 years. 3. Female sex. 4. Previous ADR. The fact that most of the ADR occur within the first three weeks of a hospital stay, combined with point 1, suggests early ADR having some predictive value for duration of hospital stay. Statistical data of type, severity, duration and pathogenesis of ADR are given. The drugs involved are mentioned.

Adolescent↗
PubMed1975

[Proceedings: Long-term therapy with antibiotics in chronic bronchitis].

Longterm therapy of chronic bacterial bronchitis assumes two forms: (a) therapy of acute exacerbations, and (b) continuous longterm prophylaxis, chiefly during the 4-7 winter months. Longterm prophylaxis should be confined exclusively to patients with two or more severe annual exacerbations. The commonest pathogens, Haemophilus influenzae and pneumococci, are usually sensitive to ampicillin and amoxycillin, cotrimoxazole (Bactrim or Eusaprim) and tetracyclines.

Amoxicillin↗