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Biomedical subjects

R K Gautam

Publications and source records attributed to R K Gautam.

29 records · Page 2Linked to original sources
PubMed1986

Immunoprofile of reactions in leprosy.

The immunologic profile during erythema nodosum leprosum (ENL) revealed increased percentage and absolute count of B-lymphocytes, in addition to considerably lowered levels of complement component C3. Serum immunoglobulins--IgG, IgA, and IgM--were significantly raised after subsidence of ENL, whereas upgrading reaction showed an increase of absolute count of total T lymphocytes and percentage and count of B-lymphocytes. In addition, a raised serum IgM level was noted after regression of ENL. Downgrading reaction demonstrated a decreased percentage of early T-lymphocytes and raised the absolute count of B-lymphocytes. Serum IgA levels were found to be increased after amelioration of ENL.

Complement C3↗
PubMed1985

Physiological acclimatization to heat after a spell of cold conditioning in tropical subjects.

The effects of brief spells of cold conditioning on heat acclimatized tropical subjects on the decay and reacclimatization status to heat were evaluated on 12 Indian male infantry soldiers in the cooler months at Delhi. After 8 d of heat acclimatization in a climatic chamber maintained at 45 degrees C dry bulb (Tdb) and 30% relative humidity (rh), the subjects were conditioned to cold for 21 d by exposing them to a temperature of 10 degrees C daily for 4 h. During the cold conditioning phase the subjects had no access to either heat exposure or strenuous work. The cold conditioning was followed by reacclimatization to heat. Significant loss in heat acclimatization status was observed, both in terms of exercise oral temperature and heart rate. The loss in status after 1 d reinduction to heat acclimatization was in the range of 45-56%. However, within 3 d all of the subjects once again regained the full acclimatization status. The cold conditioning did not alter the sweat output during the reinduction to heat phase.

Acclimatization↗
PubMed1979

Certain biochemical changes in the trachea, lungs, and heart of squirrels exposed to three principal air pollutants.

The fate of total lipids, proteins and carbohydrates in the trachea, lungs, and heart of the common ground squirrel, Funambulus pennanti, have been determined after separate exposure to three principal air pollutants, carbon monoxide (CO), sulphur dioxide (SO2), and nitrogen dioxide (NO2). Exposure to all of these gases produced edematous conditions; however, the moisture content of heart muscle was reduced. Carbon monoxide (CO) and NO2 are more toxic to pulmonary lipids than SO2. The lipid of the heart decreased, least effects noted with SO2 treatment. Mechanical properties of the lungs were changed by alteration of the lung lipids causing changes in the surface tension. Changes in protein content were caused by altered membrane permeability. Comparative data on the carbohydrates indicated adverse effects by the pollutants.

Air Pollutants↗
PubMed1978

A comparative histochemical study of lipids in the trachea and lungs of squirrel, Funambulus pennanti, exposed to three chief air-pollutants.

In the present investigation, a histochemical study of lipids have been made in the trachea and lungs of common ground squirrels exposed to three chief air-pollutants. Significant changes thus observed in pulmonary lipids have been correlated with altered mechanical properties of the lung and morphology. Supplementary biochemical findings made on total lipids indicate that CO ranks at the top effecting lipid contents of both trachea and lungs than are the SO2 and NO2 respectively. Physiological mechanism of damage has also been analysed.

Air Pollutants↗
PubMedDate not supplied

The histopathology of type I (lepra) and type II (ENL) reactions in leprosy.

The histopathological features in type I (lepra) reaction comprised a loose and disorganised granuloma in the upper and mid-dermis, dermal edema and variable cellular contents, namely, epithelioid cells, lymphocytes, giant cells, and macrophages. While ENL reactions, were characterised by predominant involvement of subcutaneous vessels, vasculitis, and polymorphonuclear infiltration in and around the blood vessels.

Epithelium↗
PubMedDate not supplied

Erythema nodosum leprosum (ENL) in histoid leprosy.

The morphological features of ENL, occurring in histoid leprosy are described. Its infrequent occurrence has been emphasised. The possible immunopathogenesis of its occurrence in histoid leprosy is briefly outlined.

Adult↗