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Biomedical subjects

R L Binder

Publications and source records attributed to R L Binder.

At least 91 records · Page 5Linked to original sources
PubMed1984

Patterns of benzo[a]pyrene metabolism by varied species, organs, and developmental stages of fish.

Microsomal preparations of liver from adults of several (teleost) fish species, including scup (Stenotomus chrysops), winter flounder (Pseudopleuronectes americanus), and killifish (Fundulus heteroclitus), metabolized the model polycyclic hydrocarbon carcinogen benzo[a]pyrene (BP) with a marked regiospecificity, forming high percentages of benzo-ring derivatives, but particularly BP-7,8-dihydrodiol and BP-9,10-dihydrodiol. The identity of these products was established by mass spectrometry of metabolites formed by scup (S. chrysops) liver microsomes compared with the spectra obtained for authentic trans-dihydrodiols. Whereas the benzo-ring dihydrodiols equaled 40-60% of the total ethyl acetate-soluble metabolites formed by liver microsomes of the various species, the K-region metabolite BP-4,5-dihydrodiol was formed in small or undetectable amounts. Microsomal preparations of kidney and gill from S. chrysops formed BP-7,8-dihydrodiol and BP-9,10-dihydrodiol in proportions like those seen with liver of the same species. Embryonic tissues of F. heteroclitus metabolized BP with a regiospecificity similar to that exhibited by adult liver microsomes. Isomeric forms of BP-7,8-dihydrodiol are potent proximate carcinogens, and activation of BP to mutagenic and carcinogenic derivatives is associated with metabolism on the benzo ring of BP. The widespread appearance of regiospecificity for this portion of the BP molecule may be reflected in structural requirements for metabolism of other hydrocarbons and indicate that fish are useful in the study of various factors that affect tumorigenesis by polycyclic hydrocarbons.

Animals↗
PubMed1984

Seborrheic dermatitis: a newly reported side effect of neuroleptics.

Of 42 chronic patients with neuroleptic-induced parkinsonism, 25 were found to have seborrheic dermatitis; this side effect was seen in only 1 of 17 acute patients with neuroleptic-induced parkinsonism. Parkinsonian symptoms may precede the onset of seborrheic dermatitis in patients receiving chronic neuroleptic treatment.

Adult↗
PubMed1983

Seborrheic dermatitis in neuroleptic-induced parkinsonism.

An increased prevalence of seborrheic dermatitis has previously been noted in idiopathic Parkinson's disease and in postencephalitic parkinsonism. Our study of 42 hospitalized patients with drug-induced parkinsonism and 47 hospitalized psychiatric patients without that disorder showed a statistically significant higher prevalence of clinically diagnosed seborrheic dermatitis in the group with drug-induced parkinsonism (59.5% v 15%). To our knowledge, this is the first report of an increased prevalence of seborrheic dermatitis with drug-induced parkinsonism.

Adult↗
PubMed1983

Neurologically silent brain tumors in psychiatric hospital admissions: three cases and a review.

Three cases are described of patients with brain tumors who presented to a psychiatric hospital with disturbances in behavior or thinking. Neurologic signs and symptoms were absent or minimal in all cases, and psychiatric signs and symptoms were intermittent in two cases. The literature is reviewed and it is noted that tumors cannot be localized definitively by their psychiatric presentation. Further, patients with psychiatric symptoms secondary to brain tumors may respond to treatment with psychotropic medications. One of these cases is the fourth patient reported in the English language literature who meets the criteria for secondary mania due to a brain tumor.

Adult↗
PubMed1981

Extrapyramidal reactions in Asians.

The authors studied systematically whether 20 Asian patients were more vulnerable to the acute extrapyramidal side effects of neuroleptics than were 20 black and 40 white patients. They found that extrapyramidal reactions were more frequent in the Asian patients and that the difference was statistically significant.

Adult↗
PubMed1981

Difficulties in follow-up of rape victims.

It has been generally recognized that it is important to do follow-up counseling with rape victims, not only for good clinical care but also to establish a research data base on the long-term effects of rape. In our study we had difficulty achieving ongoing follow-up on many of the victims. Although our sample was small, it seems representative of certain populations of rape victims previously described in the literature and in crime statistics. Several factors inherent in the trauma of rape make follow-up difficult--the victim's defenses of denial and suppression, the characteristics of some women who are more vulnerable to rape, the response of some victims to change their phone numbers and addresses following a rape, and anger at the assailant being projected on to the "assault" of the follow-up. In working with rape victims it is important to be aware of these inherent difficulties in follow-up and try to devise methods of dealing with them.

Adaptation, Psychological↗
PubMed1981

Why women don't report sexual assault.

This study was designed to determine whether or not more women are reporting sexual assault, and whether or not previously noted theories about why women do not report continue to be valid. The study revealed that only 18% of the adult women's rapes and only 11% of the assaults of children were reported. For adult women, the primary reason for not reporting seemed to combine a type of guilt as well as embarrassment. The implication of this finding is that even as external social factors change, the internal psychological barriers to rape reporting may remain.

Adolescent↗
PubMed1979

The use of seclusion on an inpatient crisis intervention unit.

Because of the use of seclusion is controversial, a retrospective study of 50 patients was designed to examine how seclusion is actually being used on a short-term inpatient crisis intervention unit. It was found that 44 per cent of the patients were secluded during their stay. Neither sex nor race seemed to be a factor in whether a patient was secluded, but elderly patients and depressed patients were less likely to be secluded. Most of the seclusions occurred on the first day of hospitalization, with the four most common reasons being agitation, uncooperativeness, anger, and history of violence. The author speculates that the use of seclusion on the crisis unit is related to the characteristics of the patient population as well as to the short duration of patient stay.

Adult↗
PubMed1979

The working through of patients' suicides by four therapists.

In 1976 four psychotherapists in training at one institution had patients who committed suicide. The therapists met as a group over a one-year period. This paper presents brief case summaries, explores the reactions of each therapist, presents conclusions regarding the mourning process following patients' suicides, and puts forth implications and suggestions for training programs. The authors conclude that it is necessary for therapists, supervisors, and training programs to recognize the inevitability of crises and tragedies when working with disturbed persons and that, though the process of mourning must be worked through individually, training settings can permit therapists to experience the pain and loneliness while providing opportunities for mastery and growth.

Attitude of Health Personnel↗
PubMed1977

Purification of alpha-L-fucosidase from various sources by affinity chromatography.

An affinity column for alpha-L-fucosidases was constructed by linking p-amino-phenyl 1-thio-alpha-L-fucopyranoside to Sepharose 4B through linkers of succinyl 3,3'-diamino-dipropylamine. Excellent purification of alpha-L-fucosidase from rat epididymis, Clostridium perfringens and Limulus polyphemus (horse shoecrab) could be effected inone step with good yield. An affinity column purification step can be introduced at any point in published purification procedures. The purified enzyme is essentially free of other glycosidases and proteolytic enzymes. The column material is stable and can be reused for at least two years.

Animals↗