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Biomedical subjects

R L Logan

Publications and source records attributed to R L Logan.

At least 19 recordsLinked to original sources

Generativity among young, midlife, and older adults.

Generativity is conceived as a configuration of psychosocial features constellated around the goal of providing for the next generation. This study used a stratified random sampling of young (ages 22-27), midlife (ages 37-42), and older (ages 67-72) adults to examine age-cohort differences in 4 generativity features: generative concern, commitments, actions, and narration. Although prevailing views on generativity (e.g., Erikson, 1963) predict a peak in midlife and decline thereafter, support for this developmental hypothesis was mixed. Midlife Ss scored higher than young and older Ss on concern and actions in a second administration of measures, but not in the first. Generative commitments and narration showed high scores for both midlife and older Ss and relatively low scores for young Ss. Generative concern, assessed with the Loyola Generativity Scale, was positively associated with life satisfaction.

Activities of Daily Living↗

Glucose tolerance, plasma insulin, HDL cholesterol and obesity: 12-year follow-up and development of coronary heart disease in Edinburgh men.

The insulin response to a standard oral glucose tolerance test (OGTT) and other anthropometric and biochemical risk factors for coronary heart disease (CHD) were measured in a random sample of 107 Edinburgh men, who were initially studied in 1976 when they were 40 and who were reexamined in 1988-89. Fasting glucose and glucose response to OGTT were higher in 1988-89 than in 1976. In contrast, insulin levels did not differ between the initial and follow-up study either before or after the glucose load. Body mass indices increased, except triceps skinfold. Changing patterns in both fasting and OGTT insulin or glucose levels in individuals were related to changes in bodyweight or in subscapular skinfolds. Modifications in serum total and HDL cholesterol were related to changes in fasting insulin and insulin area, respectively, but not to glucose data. Eleven men developed clinical CHD. Neither glucose nor insulin measures obtained in 1976 differed between those with and without CHD. Weight-height index and abdominal skin-folds were higher in those with CHD. HDL cholesterol was significantly lower (P less than 0.05). Abdominal skin-fold but not body mass index remained significant when adjusted for HDL cholesterol. This small study confirms the importance of central obesity and low HDL cholesterol but failed to identify insulin as a risk factor for CHD in this Scottish population.

Blood Glucose↗

Direct patient telephone access to the coronary care unit: its use and impact on admission delays.

Direct telephone access for patients to the Hutt Hospital coronary care unit (CCU) was established in 1989. This paper describes initial experience of 200 consecutive calls and a subsequent study of its impact on admission delays in a further 295 patients. The majority of calls were received between 4 am and noon. Those relating to chest pain made between 4 and 8 am were more likely to be followed by admission than at other times, p less than 0.001. Use of the direct line was associated with quicker admission, 212 (SE 23.2) min compared with 359.2 (23.0), p less than 0.001. For patients with myocardial infarction the difference was even greater, 115 (28.9) (median 90 min) compared with 344.9 (18.9) (median 212 min), p less than 0.001. We conclude that free telephone access to the CCU is a valuable aid to acute coronary care.

Chest Pain↗

Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol and coronary heart disease in Scotland.

OBJECTIVE: To investigate long term changes in total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol concentrations and in measures of other risk factors for coronary heart disease and to assess their importance for the development of coronary heart disease in Scottish men. DESIGN: Longitudinal study entailing follow up in 1988-9 of men investigated during a study in 1976. SETTING: Edinburgh, Scotland. SUBJECTS: 107 men from Edinburgh who had taken part in a comparative study of risk factors for heart disease with Swedish men in 1976 when aged 40. INTERVENTION: The men were invited to attend a follow up clinic in 1988-9 for measurement of cholesterol concentrations and other risk factor measurements. Eighty three attended and 24 refused to or could not attend. MAIN OUTCOME MEASURES: Changes in total cholesterol, high density lipoprotein cholesterol, and low density lipoprotein cholesterol concentrations, body weight, weight to height index, prevalence of smoking, and alcohol intake; number of coronary artery disease events. RESULTS: Mean serum total cholesterol concentration increased over the 12 years mainly due to an increase in the low density lipoprotein cholesterol fraction (from 3.53 (SD 0.09) to 4.56 (0.11) mmol/l) despite a reduction in high density lipoprotein cholesterol concentration. Body weight and weight to height index increased. Fewer men smoked more than 15 cigarettes/day in 1988-9 than in 1976. Blood pressure remained stable and fasting triglyceride concentrations did not change. The frequency of corneal arcus doubled. Alcohol consumption decreased significantly. Eleven men developed clinical coronary heart disease. High low density lipoprotein and low high density lipoprotein cholesterol concentrations in 1976, but not total cholesterol concentration, significantly predicted coronary heart disease (p = 0.05). Almost all of the men who developed coronary heart disease were smokers (91% v 53%, p less than 0.05). CONCLUSION: Over 12 years the lipid profile deteriorated significantly in this healthy cohort of young men. Smoking, a low high density lipoprotein concentration and a raised low density lipoprotein concentration were all associated with coronary heart disease in middle aged Scottish men, whereas there was no association for total cholesterol concentration. The findings have implications for screening programmes.

Adult↗

The coronary bypass waiting list: a social evaluation.

Sixty-six patients on a coronary bypass waiting list for a median time of six months, and their spouses, completed questionnaires about their work status, income loss, hospital readmissions, communication with doctors and anxiety levels. Thirty percent of patients needed heart related sick leave while listed, 32% had lost income and 20% claimed financial hardship. Reduction in work status had almost always occurred before listing. Seventeen percent had required hospital readmission. Spouse anxiety levels were raised (p = 0.009) and 45% claimed their own health had suffered. We recommend that more attention is given to the psychosocial needs of both patients and spouses during the waiting period for coronary bypass grafting.

Adult↗

The efficacy and tolerance to three doses of diltiazem in elderly patients with stable angina.

Twelve patients aged 71-82 years with chronic stable angina were treated with the calcium antagonist diltiazem in three successive doses, 180, 270 and 360 mg/day each over two weeks. Exercise tolerance increased and trinitrin consumption fell on the first dose but showed no further change on the higher doses. Heart rates at rest and on maximal treadmill exercise were significantly reduced on the highest dose only. Adverse effects were experienced by 1, 3 and 8 subjects respectively on the three doses. The most frequent was constipation which was of sufficient severity to cause three to withdraw from treatment. It is concluded that, of the three doses studied, the optimal daily dose of diltiazem for elderly patients is 180 mg/day.

Aged↗

Symptoms associated with myocardial infarction: are they of diagnostic value?

Symptoms experienced by 227 consecutive patients before their admission to the coronary care unit were identified by questionnaire and those associated with myocardial infarction (98) compared with those occurring with ischaemia (53) and chest pain or discomfort of unknown cause (29). The diagnosis of myocardial infarction by the nature of the resultant pain or discomfort was unreliable in contrast to the associated symptoms sweating, nausea, belching and vomiting. The predictive value of the latter was 91%. Nausea was associated with inferior site of infarction and development of Q waves on the electrocardiogram. Morphine administration was not followed by an increased incidence of vomiting. Back pain or discomfort during infarction was experienced twice as often by women.

Adult↗