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Biomedical subjects

R L Logan

Publications and source records attributed to R L Logan.

At least 37 records · Page 2Linked to original sources
PubMed1984

Prevention of ventricular fibrillation during acute myocardial infarction by intravenous propranolol.

A trial of intravenous followed by oral propranolol, started within 4 h of onset of suspected myocardial infarction and continued over 27 h, was carried out in 735 patients; 364 received propranolol, 371 were controls. Ventricular fibrillation during the first 48 h after entry to the trial occurred in 2 treated patients and in 14 controls (p = 0.006). Rates of hospital mortality, complications other than ventricular fibrillation, and progression from threatened to completed infarction did not differ between treated and control patients. Ventricular fibrillation was not apparently prevented by prior beta-blocker treatment, which was not a reason for exclusion from the trial. This intravenous/oral propranolol regimen seems to prevent ventricular fibrillation due to evolving myocardial infarction.

Administration, Oral↗
PubMed1984

Coronary care and rehabilitation: patient and spouse responses.

Responses and attitudes of 33 patients and their spouses to management during and after myocardial infarction were assessed by questionnaire and interview. The needs of both not only changed between the time of acute illness and recovery but also frequently differed. Desire for more information both in hospital and after discharge was emphasised. The perceived educational role of coronary care nurses differed from that of doctors. We conclude that it should be directed towards providing patients and families with general information and facilitating doctor/patient communication, rather than replacing that of the doctor in providing information about the patient's own condition and management. The rehabilitative programme appeared to help patients and families cope with what were frequently profound emotional stresses during early convalescence. As a result of this study we have looked more critically at some aspects of our patient management whilst the value of others has been reinforced.

Admitting Department, Hospital↗
PubMed1983

Coronary care at Hutt Hospital 1980-1981.

Three hundred and forty-one patients were admitted to the coronary care unit, Hutt Hospital during twelve months from 1980-1981. Of the 60 with myocardial infarction, 75% developed symptoms at home, 49% came to hospital without first seeing a doctor and 60% arrived by ambulance. The median admission delay from onset of symptoms of infarction was 3.4 hours, one hour of which was spent in the A and E department. Only 5% of all admissions were defibrillated in the coronary care unit. The higher mortality with infarction in older patients was confirmed. The practical implications of our findings are discussed.

Adult↗
PubMed1982

Blood pressure changes during convalescence after myocardial infarction.

We have retrospectively studied changes in blood pressure from CCU admission to the end of convalescence after myocardial infarction in 72 consecutive patients less than or equal to 70 years, who did not receive hypotensive therapy before or during the period of observation. Besides confirming previous observations of an initial fall and subsequent rise in blood pressure we have, in addition, identified a difference in response after large compared with smaller infarcts. The rise in systolic blood pressure after larger infarcts appears to be delayed and is greater after leaving hospital (23.3 +/- 18.5 mmHg) (3.09 +/- 2.46 kPa) than after small infarcts (14.4 +/- 19.6 mmHg) (1.91 +/- 2.6 kPa), p less than 0.05. The results emphasise the importance of checking blood pressure during convalescence following a myocardial infarction particularly after larger infarcts.

Adult↗
PubMed1982

Dietary survey in 40-year-old Edinburgh men.

One hundred and seven healthy 40-yr-old Edinburgh men were asked to participate in a dietary survey involving a 7-d weighed record. Ninety seven successfully completed the record. The results showed that the total energy was made up of 13 per cent protein, 38 per cent fat, 40 per cent carbohydrate and 9 per cent alcohol. A small proportion of the men had exceptionally high alcohol intakes. The mean intake of fat was high, 121 g, it is nevertheless lower than amounts consumed in other areas of Britain. Of the energy from fat, 16 per cent came from saturated-fatty acid, 15 per cent from monounsaturated-fatty acid and 4 per cent from polyunsaturated-fatty acid. Linoleic acid contributed 3 per cent of the mean energy intake. In some mens' diet this essential fatty acid provided under 2 per cent of their total energy consumption.

Adult↗
PubMed1981

Sustained release metoprolol: a comparison with conventional formulation in the treatment of hypertension.

Thirty patients with essential hypertension (WHO Stage I or II) completed a double blind crossover trial in which they received metoprolol as monotherapy as either a slow release formulation of 200 mg once daily or a conventional formulation of 100 mg bd. Duration of treatment was six weeks on each preparation, given in randomised order. Mean values of resting blood pressure and heart rate, measured 22 to 24 hours after the daily dose of the SR formulation or 12-14 hours after the second dose of the conventional form were significantly lower than pretreatment levels. The two treatments were equally effective and equally well tolerated.

Blood Pressure↗
PubMed1980

Symptom-limited maximal treadmill testing after myocardial infarction.

In this paper we report our experience of routine symptom limited maximal treadmill assessment, and the methodology used with patients at the end of their convalescence after myocardial infarction. Sixty-one of 68 (90 percent) consecutive patients, mean age 55.7 years (21 to 69 years), were studied at the median time after infarction of six weeks (three to 16 weeks). No complications occurred during or after the tests. Fifty-six percent of the patients studied achieved a work capacity which was within the average range reported for healthy people of the smae age. Thirty-two percent experienced chest pain thought to be angina and 31 percent developed ST segment depression of at least 1 mm without chest pain. Although ventricular premature beats occurred in half the tests the only arrhythmia requiring any treatment was a supraventricular tachycardia. The assessment of work capacity and limiting symptoms in this way after myocardial infarction is safe and is of considerable help in patient management.

Adult↗
PubMed1980

High-density lipoprotein (HDL) cholesterol in middle-aged joggers.

We have compared risk factors for coronary heart disease (CHD), including HDL cholesterol, in joggers and Rotarians aged 40 to 50 years. The only significant differences between the groups were lower resting heart rates and higher HDL cholesterol levels in the joggers. It appears that a considerable amount of exercise is required to raise HDL cholesterol levels. Significant elevation of HDL cholesterol was confined to those joggers who had either been running for at least four years or who were running 56 km per week or more.

Adult↗
PubMed1979

Coronary care and the elderly: experience in a small community hospital.

Data were collected over 20 months to assess the effect of the absence of an age-bar on admissions to the coronary care unit, Wairau Hospital, Blenheim. Patients aged 70 or more comprised 31 percent of total admissions and 38 percent of proven infarcts from which their mortality of 29 percent was more than double that of younger patients. The practical implications of these and other findings for our own hospital are discussed.

Adult↗
PubMed1977

Linoleic acid and susceptibility to fatal ventricular fibrillation in rats.

The effect of linoleic acid on the induction of fatal ventricular fibrillation by intravenous CaCl2 (10%), was studied in rats fed for a month from weaning on a diet with either a high or low content of linoleic acid. Studies were performed in the basal state and after pretreatment with noradrenaline, which increased the sensitivity to CaCl2 equally in animals from both diet groups. Despite considerable differences in the linoleic acid levels in the plasma and myocardium, the two groups did not differ in the incidence of fatal ventricular fibrillation. Our conclusions concerning the effect of linoleic acid on cardiac arrhythmias, and sudden death in particular, are compared with those from other studies.

Animals↗
PubMed1977

Histocompatibility antigens and myocardial infarction.

HLA typing was carried out in 50 Edinburgh men aged 45 years or under who had experienced a myocardial infarction and in 96 healthy 40-year-old men radomly selected from the same community. No significant differences in antigen frequencies were found, and our results therefore fail to support the hypothesis suggesting an association between HLA-B8 and haplotype A1-B8 with ischemic heart disease.

HLA Antigens↗