Biomedical subjects

R L Miller

Publications and source records attributed to R L Miller.

At least 343 records · Page 19Linked to original sources

PubMedDate not supplied

Phosphorylation of ganciclovir phosphonate by cellular GMP kinase determines the stereoselectivity of anti-human cytomegalovirus activity.

A racemic mixture of ganciclovir phosphonate was resolved by stereoselective phosphorylation using GMP kinase. The R-enantiomer of ganciclovir phosphonate was active against human cytomegalovirus but the S-enantiomer was less active. We show that enantiomeric selectivity of antiviral for ganciclovir phosphonate was conferred by stereoselective phosphorylations by mammalian enzymes, not by stereoselective inhibition of DNA polymerase from human cytomegalovirus.

Antiviral Agents↗

PubMedDate not supplied

Blood component therapy.

Blood loss in orthopaedic injuries or procedures may be substantial, and more than 23 million units of blood components are transfused each year. The most frequent components used include whole blood, packed red blood cells, platelets, plasma derivatives, leukocytes, and clotting factors. This article will discuss blood classification systems, transfusion components, administration and potential complications of transfusion therapy, and nursing implications.

ABO Blood-Group System↗

PubMedDate not supplied

Delayed splenic rupture.

Due to its location in the abdominal cavity, the spleen is a prime target for damage from blunt injury. Splenic rupture can occur immediately or it can be delayed up to 14 days following injury. A case report is presented involving a patient who sustained a ruptured spleen 2 weeks following an altercation.

Adult↗

PubMedDate not supplied

Massive cardiac involvement by malignant lymphoma.

Cardiac infiltration by lymphoma is a rare finding during life. However, metastatic deposits are frequently found at postmortem in patients with malignant lymphoma. In the past, this may have been due to difficulties in imaging the heart. Today, 2-dimensional echocardiography is a widely used, safe, noninvasive test which allows excellent spatial imaging of cardiac structures. We report a case of extensive primary myocardial and pericardial involvement by malignant lymphoma in which echocardiography was used to document the diagnosis and follow the response to chemotherapy.

Echocardiography↗

PubMedDate not supplied