PubMed Health⌕ Search

Biomedical subjects

R Lagier

Publications and source records attributed to R Lagier.

At least 55 records · Page 3Linked to original sources
PubMed1987

Distribution of immunoglobulin classes in plasma cells in various kinds of synovitis.

Sixty-five cases of synovitis corresponding to eight groups (seropositive and seronegative rheumatoid arthritis (RA), ankylosing spondylitis, psoriatic arthritis, post-traumatic arthritis, osteoarthritis, osteonecrosis and unclassified synovitis) were investigated in specimens stored as paraffin blocks. Immunoglobulin class content (heavy chains: G, A, M and their associated light chains: K, L) of the plasma cells was determined by the immunoperoxidase method. Plasma cells were observed in all cases in both RA groups but not in all cases of the other groups. All three classes of immunoglobulins were observed. The proportion of IgM cells was numerically larger in seropositive rheumatoid arthritis than in seronegative RA. However, due to the great case-to-case dispersion and small group size, this difference was not significant. A routine investigation of intracellular immunoglobulins cannot, therefore--at least with present knowledge--contribute to the diagnosis or prognosis of a given case of synovitis.

Arthritis↗
PubMed1986

Sternocostoclavicular hyperostosis. Radiological and pathological study of a specimen with ununited clavicular fracture.

Anatomico-radiological study of a sternocostoclavicular mass taken post-mortem from a man whose clinical history had shown bilateral sternocostoclavicular hyperostosis (SCCH) with plantar pustulosis for 27 years. The clavicle showed an ununited fracture attributable to a trauma sustained five years earlier. Both clavicular segments showed active remodelling with intraosseous granulation tissue and periosteal metaplastic ossification. The sternocostoclavicular region was fused in a bony block in which there were no signs of remodelling activity. The first rib and the distal extremity of the clavicle were histologically normal. These observations support the conclusions of a previous study of another case of SCCH. The condition might be due to a bone infection caused by an--as yet--unknown germ. Bone remodelling would explain the periosteal hyperostosis and the fragility of the underlying bone. Furthermore, the possibility that the condition might also be a joint disease related to the group of rheumatic diseases called spondyloarthropathies should be considered.

Adult↗
PubMed1985

Anatomico-radiological study of an ununited intracapsular fracture of the femoral neck dating back 47 years. Data relevant to osteoarthritis, bone infarct, and Paget's disease of the bone.

This is the anatomico-radiological study of a 47-year-old ununited intracapsular fracture of the hip. The femoral head was osteoporotic but its center contained a zone of osteomedullary necrosis in the form of a bone infarct. Its contour was reshaped and remnants of articular cartilage were covered by osteophyte-like bone formations; furthermore, an acetabular osteophyte was observed. Histological signs of Paget's disease of the bone were observed in the medial part of the femoral stump. The findings in this case provide the basis for a discussion of the pathogenesis of osteophytes in osteoarthritis, the pathogenesis of bone infarcts (and the distinction between this condition and another form of aseptic osteonecrosis), and the role of mechanical stresses in the development of Paget's disease of the bone.

Aged↗
PubMed1985

Bilateral deep infrapatellar bursitis associated with tibial tuberosity enthesopathy in a case of juvenile ankylosing spondylitis.

A case of bilateral deep infrapatellar bursitis is reported in a 19-year-old man suffering from juvenile ankylosing spondylitis and surgically treated for bilateral tibial tuberosity enthesopathy. In addition to erosive non-specific bone remodelling the excised specimens showed, in the bursa, synovial layer hyperplasia with mild subintimal inflammatory cell infiltration, i.e. changes similar to those of synovitis in ankylosing spondylitis. The respective roles of the inflammatory "terrain" and of local shearing stress are discussed.

Adolescent↗
PubMed1985

Histological study of a case of recurrent olecranon bursitis with mixed calcium pyrophosphate dihydrate and apatite crystal deposits.

This is the report of a light and transmission electron microscopic study of an olecranon bursitis and of the adjacent distal tricipital tendon in an 83 year-old man. The data are compared with those of a similar study in the same patient performed 2 years ago. Calcium pyrophosphate dihydrate crystals were observed in the bursal fluid, in the inner part of the bursal wall (extracellular localization and intracellular phagocytosis) as well as in the peripheral part of the tendon. In addition, small apatite deposits were observed in the bursa and tendon by electron microscopy. The origin of these bursal deposits is discussed; it is suggested that they may be related to an exchange from the tendon to the remodelled bursal wall.

Aged↗
PubMed1985

Are hip osteoarthritis and carcinomatous metastasis mutually exclusive?

A case of hip osteoarthritis is reported, in which histological investigation demonstrated the absence of tumoral involvement in femoral head in spite of nearby intraosseous carcinomatous metastasis. It comes in addition to a previously reported similar personal case. Further studies of surgical or post-mortem specimens are needed to indicate whether these observations were fortuitous or whether the two conditions might not even be mutually exclusive.

Aged↗
PubMed1985

Sudeck-type dystrophy in Paget's disease of bone. An anatomico-radiological approach.

Anatomico-radiological study of a humerus with Paget's disease and unhealed fracture makes it possible to demonstrate the uneven development of the disease according to local conditions. The possible role of a bone dystrophy similar to that in Sudeck's disease which might - along with a slow virus infection - be involved in the development of Paget's disease is discussed. The discussion is based on the present case, on two previous studies as well as on data found in the literature.

Aged↗
PubMed1985

Acute synovitis with intra-articular apatite deposits in an osteoarthritic metacarpophalangeal joint.

A patient was shown to have acute arthritis in a metacarpophalangeal joint, with local calcification indicated by x-rays. Surgical and pathological examinations showed strictly intra-articular apatite crystal deposits and an erosive osteoarthritis. These crystal deposits could account for the synovial inflammation; they are thought to be related to bone fragments embedded in the synovium. The predisposing role of previous local injections of corticosteroids is debatable.

Acute Disease↗
PubMed1985

[Malignant bone tumors of the hip. Anatomo-radiological correlation].

The anatomo-radiological study was conducted in 6 cases of isolated malignant intra-osseous tumours of the hip: 1 osteogenic sarcoma of the femoral head, 1 supra-acetabular chondrosarcoma, 3 carcinomatous metastases of the femoral head (2 predominantly lytic and 1 osteosclerotic), 1 supra-acetabular carcinomatous metastasis. This study reveals why, in the early stages of the disease and depending on the experience of the observer, the radiological appearance of these lesions can be easily confused with those of various conditions frequently seen by the rheumatologist. The authors also discuss the interactions of the metastases with the biomechanical conditions of the affected bone.

Adenocarcinoma↗
PubMed1985

Fibular lipoma with areas of bone infarct calcification.

An anatomico-radiological study of a painful intraosseous lipoma of the fibula is reported. A blown up cortex and a rearrangement of surrounding cancellous bone trabeculae were observed. The lipoma contained two small bone infarcts. A radiological differential diagnosis with calcified chondroma as well as the pathogenesis of the condition are discussed.

Adult↗
PubMed1984

Juxta-acetabular mucoid cyst in a patient with osteoarthritis of the hip secondary to dysplasia.

A marginal acetabular notch associated with a soft tissue mucoid cyst was observed in a 54 year old woman suffering from osteo-arthritis of the left hip with bilateral hip dysplasia. This condition is compared with observations made in patients suffering from osteo-arthritis of the knee with similar findings on the medial tibial condyle. The role of enthesopathic factors in the pathogenesis of such changes is postulated.

Cysts↗
PubMed1984

Osteopoikilosis: a radiological and pathological study.

Anatomico-pathological and radiological studies of osteopoikilosis were performed in two cases, one involving a femoral head, excised after a fracture of a femoral neck, in an elderly man and the other following biopsy of an iliac crest in a young woman. In both patients wide-spread radiological evidence of the disorder was present as an incidental finding. The radiological appearance of rounded and linear densities corresponded to old and inactive remodelling of spongy trabeculae in epiphyseal and metaphyseal locations. The distribution and appearance of these osteopoikilotic densities suggested them to have been related intimately to mechanical strain on spongy bone trabeculae. The diffuse nature of the lesions, their hereditary character, and their possible association with abnormalities of the skin suggest the existence of a particular terrain in which general metabolic conditions of connective tissue may interact with mechanical stresses in bone. Careful analysis of the findings in osteopoikilosis is desirable in order to provide data concerning the physiopathology of the skeleton and to permit more definitive interpretation of localised areas of bone condensation, including those observed not only in solitary bone islands and such conditions as osteopathia striata, but also those associated with infections and tumours.

Adult↗