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Biomedical subjects

R Lagier

Publications and source records attributed to R Lagier.

At least 73 records · Page 4Linked to original sources
PubMed1984

Localized Sudeck's dystrophy and distal interphalangeal osteoarthritis of a finger: anatomicoradiologic study.

After an injury to the right ring finger, a 44-year-old woman experienced pain in the distal interphalangeal joint. A subcutaneous mucoid cyst was noted near the joint. The x-ray films revealed no fracture but a narrowing of the joint space and a well-defined radiolucent area in the ulnar condyle of the middle phalanx. The biopsy specimen of this area excluded infection or tumor and revealed active osteogenic remodelling. These elements permitted a diagnosis of distal interphalangeal osteoarthritis that was associated with highly localized Sudeck's dystrophy (also called " parcellar algodystrophy"). This unusual case suggests the possibility that this dystrophy might be favored by an "osteoarthritic terrain" and might also play a role in the evolution of the osteoarthritis.

Adult↗
PubMed1983

An ultrastructural study of articular chondrocalcinosis in cases of knee osteoarthritis.

A study was made by transmission electron microscopy of tissue specimens (cartilage, meniscus and synovial membrane) taken from 5 knees presenting radiological and anatomical signs of articular chondrocalcinosis and osteoarthritis. It was part of a broader study which included analysis of the same specimens by macroscopy and light microscopy as well as by X-ray diffraction of the mineral deposits. In cartilage and meniscus juxta-cellular calcium pyrophosphate dihydrate (CPPD) crystals of variable sizes were observed in the extracellular organic matrix, independent of the collagen fibrils. They occurred mainly in the superficial and middle zones but could also be seen intermingled with the apatite crystals in the cartilage calcified zone. In synovial membrane most of the CPPD crystals were extracellular but some of them could be seen in cytoplasmic phagocytic vacuoles. These observations are in agreement with those in the literature regarding the ultrastructural picture of chondrocalcinosis and support the thesis that the crystals originate in the cartilage and are phagocytized in the synovial membrane. Although the results of the present study do not provide direct evidence of a relationship between chondrocalcinosis and osteoarthritis, the data of the ultrastructural investigation appear nevertheless of great interest as a complement to the data furnished by light microscopy.

Adult↗
PubMed1983

Brodie's abscess in a tibia dating from the Neolithic period.

Radiological and macroscopic characteristics typical of Brodie's abscess were observed in inferior metaphysis of a tibia estimated to be 5,000 years old. The use of rigorous anatomico-radiological criteria in studies of bone paleopathology can provide the doctor with accurate data regarding diseases of the past in bone specimens rarely at their disposal. This approach is also necessary to obtain valid data for paleontologists, prehistorians and archeologists.

Abscess↗
PubMed1983

Algodystrophy of the knee. Anatomo-radiological study of a case.

Presentation of a case of algodystrophy (i.e., Sudeck's dystrophy) of the left knee, affecting the femur, tibia and patella. It was brought on by a simple movement made while playing tennis and it recurred subsequently accompanied by algodystrophy of the corresponding foot. Histological study of the biopsy material showed the classical image of cortical and cancellous bone atrophy with non-specific remodelling which explained the increased uptake on the scintigraph as well as the repairing of the bone tissue observed on the X-rays. Reasons are given for the choice of the term algodystrophy to describe the condition.

Biopsy↗
PubMed1983

Enthesopathic erosive lesions of patella and tibial tuberosity in juvenile ankylosing spondylitis. Anatomico-radiological study of a case with tibial bursitis.

The authors report the case of a 20-year-old joiner suffering from ankylosing spondylitis, with recurrent knee effusions from the age of 11 and radiological evidence of sacro-iliac involvement. The patient presented with pain and bone erosions localized to the sites of tendinous attachments in the upper pole of the left patella and in tibial tuberosities. On both sides an inflammation of deep infrapatellar bursa was observed on anatomical examination. These destructive lesions are considered as rare forms of the erosive enthesopathy which has been described in ankylosing spondylitis, particularly on spine and calcaneum. They could be considered as highly localized forms of algodystrophy.

Adult↗
PubMed1983

Spondylodiscal erosions due to gout: anatomico-radiological study of a case.

The necropsy of an 84-year-old woman with painful polyarticular gout showed a severe erosion of the L2 vertebral body due to sodium urate deposition. The radiological signs of this tophus had existed for many years; it had caused recurrent pain but no neurological complications. A small tophus and a Schmorl's node on 2 neighbouring thoracic vertebrae permitted the differentiation between vertebral plate erosion in the first, which was of bone origin, and vertebral plate remodelling in the second, which originated in the cartilaginous tissue of the disc.

Aged↗
PubMed1983

Presumed calcified leiomyoma of the uterus. Morphologic and chemical studies of a calcified mass dating from the Neolithic period.

An isolated, calcified mass was found among human skeletal remains that were approximately 5,000 years old. A systematic study was undertaken that included histologic examination (stained sections, polarized light microscopy, microradiographs, and electron microscopy), x-ray diffraction, and concentrations of hydroxyproline and fluorine. The results allowed us to eliminate the diagnoses of bone tissue and intracavitary deposits such as bezoar and calculi. The mass consisted of calcified tissue, with a collagenous organic matrix and deposits of apatite, and it most probably was a calcified uterine leiomyoma.

Decalcification Technique↗
PubMed1983

Partial algodystrophy of the knee. An anatomico-radiological study of one case.

A 62-year-old man presented with intense pain in the right knee experienced immediately after slipping. The radiograph taken during the following weeks showed the development of a localized radiotranslucence of the lateral femoral condyle. Bone biopsy excluded an infectious process or tumor and revealed the histological characteristics of Sudeck's bone dystrophy. The clinical, radiological and histological data considered together were consistent with a diagnosis of "partial algodystrophy", a term considered preferable to "transient osteoporosis". The diagnosis was confirmed on clinical and radiological followup.

Biopsy↗
PubMed1982

Olecranon bursitis related to calcium pyrophosphate dihydrate crystal deposition disease.

A case of olecranon bursitis in an 81-year-old patient is presented. Analysis of the bursal fluid revealed positive birefringent crystals; radiographs showed calcifications in the distal triceps tendon. A bursectomy was performed. X-ray diffraction analyses demonstrated calcium pyrophosphate dihydrate patterns in a subcutaneous "tophus" and in a specimen of the tendon. On histologic examination, there was a bursitis with positive birefringent crystals on the bursa's inner surface; histologic images of "chondrocalcinosis" were observed in and around the tendon. It is concluded that bursitis may be part of the extraarticular manifestations of calcium pyrophosphate dihydrate crystal deposition disease.

Aged↗
PubMed1982

Biochemical findings in blood of aged patients with femoral neck fractures: a contribution to the detection of occult osteomalacia.

A study was made in Geneva of 44 patients with femoral neck fractures and no risk factor of osteomalacia to determine concentrations of 25OHD3, calcium, phosphorus, alkaline phosphatase, albumin, and globulins in blood. The results were compared with those obtained for control groups of adult and aged subjects, as well as of 21 subjects operated on for hip osteoarthritis. For the detection of occult osteomalacia, femoral head bone tissue from 14 patients with fractures was examined by histomorphometric methods. In more than a third of the cases, 25OHD3 and serum albumin values were lower than those found for adult and even aged control subjects. Some slight histological signs of osteomalacia were observed in 1 patient with a femoral neck fracture, but there was no correlation between the histologic and the blood data. In practice, when dealing with aged people with no obvious risk of osteomalacia, it is important that a systematic antiosteomalacia treatment consisting of large supplements of vitamin D be avoided and that the conditions of diet and living be carefully controlled.

Adult↗
PubMed1982

Calcium oxalate deposition in growing bone: anatomical and radiological study in a case of primary oxalosis.

A combined radiological, histological, and crystallographical study of bone, primarily the inferior femur, taken at autopsy from a 9 year old female with primary oxalosis, is reported. The essential feature is the deposition of calcium oxalate monohydrate (whewellite) crystals, inducing a foreign body reaction and bone remodelling. Synovial and cartilage surfaces are not involved. The changes occur primarily at sites of previous or present growth and seem to be related to the reaction of tissue to the deposition of blood-borne crystals. The radiological changes may be explained in part by the deposition of crystals at Harris' lines of growth arrest. Cancellous bone also shows changes similar to those observed in renal osteodystrophy.

Blood Vessels↗
PubMed1982

Anatomico-radiological study of intraosseous epidermoid cysts.

Anatomico-radiological study of 8 cases of intraosseous epidermoid cysts (1 in the skull, 6 in distal phalanges of the hand, 1 in distal phalanx of the foot with invasion of the adjacent joint). The epithelium was malpighian with hyperkeratosis (therefore the scales filled the cavity), sometimes with parakeratosis and even dyskeratosis but without signs of malignancy. The adjacent connective tissue and bone reactions were more active in the phalanx than in the skull and this could explain the frequent pain in the phalanges. The bone remodelling explains the radiological pictures and sustains the differential diagnosis. In 5 out of the 8 cases (particularly in the skull) a history of previous local trauma was present. However, the etiological importance of trauma should be discussed with respect to that of dysembryoplasia.

Adult↗