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Biomedical subjects

R Lagier

Publications and source records attributed to R Lagier.

At least 109 records · Page 6Linked to original sources
PubMed1978

Anatomy and radiology of a bone island.

Anatomoradiological study, on an amputation specimen for osteosarcoma from a 13 year old girl, of a bone island in the distal femoral epiphysis. It consists of a mature bone core caused by localized remodeling of the spongeous trabeculae, old but still slightly active, clearly different from a bone infarct, a tumoral or infectious process. Discussed the interest of a precise radiological study for making the diagnosis (particularly xerography), the risks of error involved in scintigraphy and the utility of a block excision if a biopsy is performed.

Adolescent↗
PubMed1978

Diffuse enthesopathic hyperostosis--anatomical and radiological study on a macerated skeleton.

Anatomico-radiological study of a macerated skeleton in a 43-year-old diabetic woman. An important spondylosis with hyperostosis of the cervical, thoracic and lumbar vertebrae was seen. There were associated changes of insertional hyperostosis at various levels, particularly at the iliac crests. Paget's disease of the left iliac crest was also noted in the corresponding hyperostosis. This case presentation offers an opportunity to discuss local mechanical factors (observed at the tendinous insertions) as well as generalized considerations on the "terrain" of diabetes and perhaps malnutrition. It also demonstrates the interest that an anatomico-radiological comparison on macerated specimens can have for certain osteoarticular research, teaching and paleopathology.

Adult↗
PubMed1978

Calcaneal cysts. A radiological and anatomico-pathological study.

A radiological and anatomico-pathological study of 17 cases of calcaneal cysts in young patients without other known affections is documented. There are two essential histological characteristics of the fibrous wall lining the cysts: (1) hemosiderin deposits together with cholesterol and an associated giant cell reaction, which can be attributed to previous hemorrhages; (2) newly formed bone--similar to that observed in solitary cysts of the humerus and femur--applied to preexisting trabeculae which forms a bony wall explaining the typical radiological picture. These uncommon cysts may be the evolution of purely local hemorrhages in the trigonum calcis.

Adolescent↗
PubMed1977

Tendon calcifications in chondrocalcinosis. A clinical, radiologic, histologic, and crystallographic study.

Fine linear extraarticular calcium deposits were found in X-rays of 7 of 52 patients with articular chondrocalcinosis (ACC). Seven Achilles tendons, seven quadriceps tendons, and one plantar fascia were affected. In a control group of comparable age and sex, without ACC but with generalized osteoarthritis, no calcifications were found in the tendons. On a biopsy specimen of Achilles tendon with such calcium deposits, X-ray diffraction showed that they had the characteristics of calcium pyrophosphate dilhydrate. Isolated small foci of crystals were observed on some segments of tendon bundles. The presence of fine linear calcifications on X-rays of the Achilles or quadriceps tendons may be a useful aid in the radiologic diagnosis of so-called articular chondrocalcinosis.

Achilles Tendon↗
PubMed1977

Spondylosis in the whale--an anatomicoradiological study of an osteophyte.

This report describes a macroscopic and radiological study (on a dry specimen) of a whale vertebra having an osteophyte of spondylosis similar to those present in man and other mammalians. This osteophyte has a remodelled and dense structure different from that of the normal neighbouring bone of the vertebral body (which has the particular bone structure of a cetacean). The study of the osteophytes and the bridges of sponylosis in the marine mammalians offers particularly favourable conditions for a better dissociation of the pre-existing vertebral body and the extrinsic bone which was newly developed under the influence of mechanical factors.

Animals↗
PubMed1977

Post-traumatic sinus tarsi syndrome. An anatomical and radiological study.

Four cases of sinus tarsi syndrome are presented. They were studied by means of arthrography of the posterior subtalar joint and histological examination of sinus tarsi soft tissue. The obliteration of synovial recesses on posterior subtalar joint arthrography can be explained by synovial hyperplasia and by cicatricial remodelling of ligament tissue.

Adult↗
PubMed1977

[Pseudospondylolisthesis and chondrocalcinosis].

Degenerative spondylolisthesis L4-L5 progressing rapidly toward a surgical intervention for a sciatica in a 52 years old female. The radiography, as well as an anatomo-pathological study, showed an erosive osteoarthrosis of the vertebral articular processes. The disc biopsy revealed a chondrocalcinosis which was also found in the knees on radiological examination. This observation provides, at the spine, a special example of "erosive osteoarthrosis with chondrocalcinosis".

Chondrocalcinosis↗
PubMed1977

[Hyperostosis of the iliac crest. Anatomo-radiologic features].

Anatomical and radiological features of two cases with hyperostosis of the iliac crest are related. They help to illustrate a brief discussion of the general prcal factors as well as general medical conditions (especially diabetes mellitus, for which careful clinical investigations should be performed when hyperostosis is discovered radiologically); 2) histological structure; 3) differentiation from osteophytes of osteoarthrosis.

Diabetes Complications↗
PubMed1977

Synovial reaction caused by adjacent malignant tumors: anatomicopathological study of three cases.

Three patients are described, each having a malignant bone tumor associated with inflammatory episodes in the adjacent joint. Two of these were sarcomas of the lower end of the femur, and one a metastatic carcinoma in the distal end of the radius. Histologically, the synovium exhibited moderate and non-specific signs of inflammation near the malignant tissue. These cases illustrate the possibility of diagnostic error, either clinically or on microscopic examination of small specimens, especially in punch biopsies.

Adult↗
PubMed1976

Synovial deposit of osmic acid after intra-articular injection. Anatomical and radiologic study of a case.

An anatomical and radiologic study of a synovial autopsy specimen 32 months after an intra-articular injection of osmic acid for the local treatment of a rheumatoid synovitis. Osmium deposits are seen within peripheral cells of a fat lobule and also in a few histiocytes of the scar tissue which replaced the rheumatoid synovitis. These osmium deposits in the fat cells are present in a sufficient quantity to give a radiologic opacity.

Adipose Tissue↗
PubMed1976

[Industrial fluorosis].

43 potroom workers (aluminium industry) with fluorosis have been compared with 18 foundry workers of the same age, but who had never been exposed to fluorides. Clinical examination revealed a higher incidence of articular pain and limitation of motion in the exposed group. The diagnosis of fluorosis is not only clinical but calls for other investigations such as urinary fluoride determination, bone radiology and, above all, bone biopsy for fluoride determination, histology and microradiography.

Aged↗
PubMed1976

An anatomicopathological approach to the study of articular aging.

Bone and joint aging results from the combined action of various metabolic and mechanical factors. Osteoarticular aging produces primary changes in bone (intrinsic rarefaction, but also extrinsic osteogenesis), cartilage, synovial membrane, and tendon. The association of these primary changes can result basically in three anatomicopathological entities: hyperostosis and osteophytes at tendon insertions, senile remodeling, and osteoarthritic remodeling. Some of these entities are asymptomatic. Others form part of nosologic entities such as osteoarthritis and various types of joint pain and stiffness. The standard methods of morbid anatomy provide a link between clinical findings and modern research methods. By separating nosology and morphology they permit a better analysis of the boundaries and transitions between articular "aging" and "disease". With advancing age, osteoarthritis becomes increasingly frequent but not inevitable.

Age Determination by Skeleton↗
PubMed1976

[Anatomopathology of Paget's disease. Combined approach by conventional methods and ultrastructural study].

Paget's disease is manifested by bone remodelling where the rate of the resorption-osteogenesis pattern is abnormally enhanced. This leads to the formation of a pathologically structured bone. The bone remodelling does not concern the entire skeletal structure and is unequally active. It is limited by the neighbouring healthy bone in which it can spread out. It can be followed by the development of a sarcoma. When the acetabulum or the femoral head are affected this can occasionally, lead to a coxopathy with cartilage deterioration. An anatomo-pathological study of Paget's disease is necessary for understanding the basis and the limits of biopsy diagnosis as well as its various manifestations (clinical, radiological, biological, scintigraphical, thermographical). This study also serves as a basic for pathogenic discussion.

Aged↗
PubMed1976

Osmium deposits detected by x-ray after synoviorthesis of the knee.

A study of 113 knees of 72 patients treated with intra-articular injection of osmic acid for chronic exudative synovitis caused by various rheumatic diseases is reported. Certain cases presented abnormal radiological opacities, statistically more frequent after the injection of 200 mg than after 100 mg of osmic acid (33.9% and 15.7%). These images appear early after the injection and can remain for years. They should not be confused with intra-articular calcium deposits, or with synovial ossifications or various periosteal osteogenic processes. Their appearance does not seem to be related to the rheumatic disease treated or the therapeutic result obtained. They reflect the fixation of osmium in the synovial fatty tissue, which causes a fibrous reaction at this level. Their longterm action in the cicatrization of the synovia, or their part in a relapse of an inflammatory episode should be clarified.

Adult↗
PubMed1976

Radiological opacities of the knee after intra-articular injections of osmic acid.

Unusual radiological opacities have been observed in 29 cases after intraarticular injection of osmic acid in 113 knees of 72 patients under treatment for a chronic exudative synovitis in different types of rheumatic diseases. They are statistically more frequent after the injection of 200 mg than after 100 mg (33.9 and 15.7% respectively). Most of the time, they are located in the suprapatellar pouch. The opacities appear soon after the injection and can last for several years. They do not seem to have an unfavorable influence on the clinical course. They appear to be caused by a deposition of osmium in synovial fat tissue. From here the osmium might stimulate fibrosis. The radiological image has to be differentiated from intra-articular calcifications, synovial ossifications and various periosteal osteogenic processes.

Adult↗
PubMed1975

Apophysiolysis of the anterior inferior iliac spine. A histological, clinical and radiological study.

Four cases of avulsion of the anterior inferior iliac spine were presented. Three of them affected boys of about 15 years (2 after a strain without local trauma--1 after local trauma). The fourth was discovered by chance on the X-rays of a man. Histological examination was made of 2 cases. A recent one showed the remodelling of a fracture of the apophysary growth cartilage. An older one showed aspecific bone remodelling. The incidence, clinical and radiological data, pathology and pathogenesis of such apophysiolysis is discussed.

Acetabulum↗
PubMed1975

Pathology of "knuckle pads". Study of four cases.

Histological study of four cases of knuckle pads. The main lesion is a fibroblastic proliferation which developes into dense fibrosis. It is analogous to that found in Dupuytren's contracture or Ledderhose's disease, with which knuckle pads are often associated. This histological feature and the clinical characteristics suggest a nosological entity of nodules situated at the back of the fingers, as a distinct form of fibromatoses and help to delineate knuckle pads from an abarticular manifestation of inflammatory or degenerative rheumatism.

Adult↗