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Biomedical subjects

R Lagier

Publications and source records attributed to R Lagier.

At least 91 records · Page 5Linked to original sources
PubMed1980

Carpal tunnel syndrome in chondrocalcinosis of the wrist. Clinical and histologic study.

Carpal tunnel syndrome (CTS) defined electromyographically was found in 8 of 22 unselected patients with chondrocalcinosis of the wrists (bilateral in 6, unilateral in 2). Thenar atrophy was the most frequently encountered clinical sign. In the hands with CTS, calcifications of the wrist were more extensive than in the hands, without CTS. Degenerative joint changes of the hands were significantly more frequent in the group suffering from CTS. Surgery was performed in 5 patients with CTS. Microscopic examination of the volar carpal ligament and the flexor synovial tendon sheath failed to reveal histologic signs of chondrocalcinosis. However, the presence of scarce crystals, as seen in polarized light as well as electron microscopy, suggests a minor form of chondrocalcinosis.

Adult↗
PubMed1980

Bilateral osteochondritis dissecans of the carpal scaphoid. A radiological and anatomical study of one case.

The results of an anatomical and radiological study of one unusual case of bilateral osteochondritis dissecans of the carpal scaphoid are reported. On both sides, histological examination of the excised surgical specimen showed previous remodelling of the bone and marrow which had been followed by further aseptic necrosis. On the painful left side the sequestrum itself was fractured and appeared to be involved in a localised cystic remodelling reaction. The observations are discussed as an example of the histological changes in aseptic bone necrosis as well as an unusual type of pathology affecting the carpal scaphoid.

Adult↗
PubMed1980

Hip arthropathy in ochronosis: anatomical and radiological study.

Anatomical and radiological studies of four cases of ochronotic arthropathy of the hip were based on the examination of a total of six surgically removed femoral heads. One of these had undergone a surgical biopsy 10 years previously. The impregnation of the articular cartilage by the ochronotic pigment causes it to break into small fragments in the weight-bearing zone. This results in a similar osteoarthrotic remodeling to that commonly attributed to the histologically different "degenerative chondropathy". The labelling of the cartilage in ochronotic arthropathies offers an opportunity for better understanding of the main nonspecific components of osteoarthrotic remodeling. An anatomico-pathological approach explains why their radiological images in the hip may simulate those of rheumatoid arthritis.

Adult↗
PubMed1980

The concept of osteoarthrotic remodelling as illustrated by ochronotic arthropathy of the hip. An anatomico-radiological approach.

This report is an anatomico-radiological study of six femoral heads excised from four patients with diffused ochronotic arthropathy. In one case a biopsy specimen taken eleven years earlier was also studied. The deterioration of the ochronotic cartilage involves a fragmentation process reflected by histological characteristics that are different from those observed in common "cartilaginous degeneration". The fragments resulting from this process become embedded in the remodelled bone-marrow tissue of the weight-bearing zone and in the synovial membrane. Except for the presence of pigmented cartilage, the intrinsic osteogenic remodelling and the extrinsic osteophytic remodelling (the latter often appearing in the form of minor equivalents) are similar to that of the common form of osteoarthrotic remodelling. The pigment labelling of the ochronotic cartilage provides a particularly favorable opportunity to study the general problem of osteoarthrotic remodelling; it facilitates the differentiation between newly formed and preexisting tissue and consequently our understanding of the entire process. An anatomico-radiological approach provides an explanation for the similarity frequently observed on X-rays between ochronotic and rheumatoid hip arthropathies.

Aged↗
PubMed1980

Skeletal changes in congenital fibrinogen abnormalities.

We report an anatomico-radiologic study of humerus, femur, and tibia from a case of total congenital afibrinogenemia. Juxtatrabecular hemorrhages occur mainly in metaphyses and seem to be related to normal lines of stress. They may lead to the formation of intraosseous cysts and to a remodelling of bone trabeculae. The radiologic lesions in a second case, diagnosed as congenital dysfibrinogenemia, are similar to those found in Case 1 (femoral trabeculae remodelling) but also resemble some alterations described in hemophilia (pseudotumor of the right iliac bone). Anatomic study of the lesions in Case 2 was not possible. The significance of these observations could be better defined by a more extended skeletal study (radiologic and when feasible anatomic) of patients with congenital clotting defects and especially with inherited disorders of the fibrinogen molecule. It would also be worthwhile investigating manifest or latent hemostatic disorders (particularly at the fibrinogen level) in patients with solitary or aneurysmal bone cysts, and even with bone infarct or unexplained trabecular remodelling.

Adult↗
PubMed1979

[is there an osteomalacia component in femur neck fractures?].

In 29 patients with fractures of the femoral neck (group A) and 22 patients operated on for osteoarthritis of the hip (group) B), plasma levels of 25-hydroxycholecalciferol (25-OH-D3) were compared with the results of histological bone tests. A third group of 19 patients at the Geriatric hospital served as a control in this age group for 25-OH-D3 values (group C). The average level of 25-OH-D3 was 9.64 +/- 5.8 micrograms/l in group A and 13.25 +/- 7.6 micrograms/l in group B. This difference is not significant. On the other hand, the difference between groups B and C (9.31 +/- 4.04) is significant (2 p less than 0.05). Evaluation of the histological sections did not reveal evidence of osteomalacia. Generally speaking, the levels of plasma 25-OH-D3 in these patients were low, but without signs of osteomalacia on histological evaluation.

Aged↗
PubMed1979

Phagocytosis of chromium during patellar osteoarthritic remodelling associated with a knee prosthesis.

The report is of an anatomico-pathological and electron probe microanalyzer study of a patella with osteoarthritic remodelling, that had been in contact with a cast cobalt-chromium-molybdenum prosthesis for two years and seven months. Abrasion of the metal resulted in preferential phagocytosis of chromium, principally in the wall of an osteoarthritis cyst. This observation indicates that a substance administered by intra-articular pathway for the treatment of osteoarthritis can become phagocytosed, and quite deeply, in the remodelled bone.

Aged↗
PubMed1979

Articular changes due to disuse in Sudeck's atrophy.

Two cases of Sudeck's atrophy of the foot occurring 16 months and 17 years after infected fractures of the leg were studied radiologically and pathologically. Various cartilaginous changes were observed, the nature and severity of which depended on the joint involved. They included superficial pannus, deep erosion, fibrous ankylosis and, at times, bony ankylosis. These changes are similar to those observed in nine cases studied by Rutishauser et al. Comparison of the pathological changes in human and experimental joint immobilization suggests that these changes are due mainly to decreased mobility of the joints of the foot in Sudeck's atrophy. These observations also suggest that physiotherapeutic mobilization in Sudeck's atrophy is important for the joints as well as for bone. From a more general point of view, they demonstrate that a condition which is nosologically different from the chronic rheumatic diseases can nevertheless cause lesions that are a fundamental part of the pathological changes in osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.

Adult↗
PubMed1979

Lumbar erosive intervertebral osteochondrosis. Anatomico-radiological study of a case.

A radiological and anatomical case study of intervertebral osteochondrosis is presented. X-rays reveal its evolution from an isolated Schmorl's node to a more diffuse lumbar intervertebral osteochondrosis. Macroscopical and microscopical post-mortem examination shows various degrees of disc deterioration with cartilaginous plate flaw and localized or diffuse intravertebral disc herniation. A discussion on the origin of this cartilaginous plate weakness and on the respective significance of the X-ray and biopsy in the differential diagnosis between intervertebral osteochondrosis and infectious spondylitis follows.

Aged↗
PubMed1979

[The role of ochronotic arthropathies in rheumatology].

In alkaptonuric patients, cartilage, fibrocartilage and tendons are slowly impregnated by homogentisic acid. This leads to pigment deposition between and on the surface of collagen fibres (ochronosis) which hardens the tissues as in leather tanning, and can render them breakable. Ochronotic intervertebral discs show a tendency of calcification and ossification, which produces a characteristic radiological picture. Ochronotic cartilage is rather often split off in the weight bearing zones of the knee, shoulder and hip. This is followed by osteoarthrotic changes with a synovial reaction frequently leading to an osteochondromatosis. The labelling of the pigmented ochronotic cartilage thus can support a didactic demonstration of the nature of osteoarthrotic remodelling. It underlines that such remodelling consists mainly of non specific changes developing independently of the cause of the original cartilage lesion.

Alkaptonuria↗
PubMed1979

Anatomo-radiological study of a case of post-radiotherapeutic osteolysis of the hip.

Anatomo-radiological study of a case of osteolysis of the femoral head and neck in a 56-year old male who had recieved, 22 years earlier, an intense radiotherapeutic treatment for a soft tissue tumour of the corresponding hip region. The treatment is considered as being the main etiological factor responsible for the bone lesions. The latter seems to have been favored by an indolent joint due to a thoracic cordotomy for post-irradiation pains; it may have been prepared by a secondary osteodystrophy which preceded the radiotherapy and seems due to two previous surgical excisions.

Bone Resorption↗
PubMed1979

[Incidence of chondrocalcinosis in a series of 1,000 surgically excised intervertebral disks].

This study is based on the histological examination of a series of 1000 intervertebral discs which were excised surgically for a painful spinal or nerve root syndrome. The authors observed in 31 cases (18 men and 13 women) a chondrocalcinosis that was not found clinically (small circumscribed deposits of crystals identified as calcium pyrophosphate after examination in compensated polarized light microscopy). The frequency is higher than that of chondrocalcinosis observed in the menisci excised surgically from the knees of subjects with the same average age; but it is lower than that for the menisci taken from autopsy material of subjects with a higher average age. The histological examination of all surgically excised discs would permit the findings of signs of chondrocalcinosis, thus emphasizing the risk for the patient of a further evolution to arthropathies (spinal or peripheral). This can offer bases for statistical longitudinal studies.

Adolescent↗