Biomedical subjects

R Lilleng

Publications and source records attributed to R Lilleng.

22 records · Page 2Linked to original sources

PubMedDate not supplied

The comedo subtype of intraductal carcinoma. Cytologic characteristics.

Smears from 10 intraductal carcinomas of the comedo type without microinfiltration were compared with smears from 10 similar tumors with suspected or proven microinfiltration and smears from 10 invasive comedo carcinomas. Microinvasive tumors could not be separated from purely intraductal cases unless tumor cell infiltration in mammary fat was seen in the smear. The tumor cells in most of the intraductal cases were shed in cohesive groups and clusters, lying in necrotic cellular debris and with few or no scattered, single, dissociated tumor cells. Smears from invasive comedo carcinomas invariably showed tumor cell clusters and scattered, single, dissociated tumor cells, often with atypia in excess of what was seen in the intraductal cases. Also, in most cases the invasive tumors did not show a background of necrotic cellular debris.

Adult↗

PubMedDate not supplied

A one-year audit of fine needle aspiration cytology of breast lesions. Factors affecting adequacy and a review of delayed carcinoma diagnoses.

OBJECTIVE: To compare the rate of inadequate specimens in a triple-diagnosis breast clinic with that of specimens taken by clinicians. STUDY DESIGN: Breast aspirates obtained in 1993, 2,923 specimens, were reviewed. Of these, 1,515 (51.9%) were taken in a specialist clinic with a triple approach (clinical examination, imaging and aspiration cytology). Palpable lesions were aspirated by a cytopathologist and nonpalpable lesions by a cytopathologist and radiologist in cooperation using imaging techniques. The rate of inadequate specimens was determined and compared with the rate of the remaining specimens, which were sent to the laboratory by clinicians. RESULTS: In the breast clinic, the inadequacy rate was 3.8% (n = 58). The inadequacy rate for the 1,408 mailed breast aspirates was 14.8% (n = 209). A cancer diagnosis was recorded in 13.5% (n = 395). Six carcinomas were diagnosed late because of inadequate specimens. CONCLUSION: The inadequacy rate was lower in cytology samples taken in a specialized breast clinic than in samples mailed to the laboratory by clinicians. In order to increase the detection rate of malignancies, clinicians performing fine needle aspiration should be trained in the aspiration technique and smear preparation.

Biopsy, Needle↗

PubMedDate not supplied

Assessment of fine needle aspiration cytology and histopathology for diagnosing male breast masses.

OBJECTIVE: To investigate the diagnostic accuracy of fine needle aspiration cytology (FNAC) from breast lesions in males and to determine the frequency of benign versus malignant histopathologic diagnoses in surgical biopsies from male breast lesions. STUDY DESIGN: FNAC specimens from breast lesions taken from 241 males over 8.5 years were divided into four subgroups according to the original cytologic diagnoses. Diagnostic accuracy was verified with the Norwegian Cancer Registry. Ten years' worth of material from 809 surgical biopsies from male breast lesions was subgrouped according to the original histopathologic diagnoses. RESULTS: Of the 809 surgical biopsies, 779 (96.3%) were benign lesions. Of the 241 fine needle aspirates, 27 (11.2%) were unsatisfactory for cytologic diagnosis. Of the remaining 214 cases, 200 benign cytologic diagnoses were confirmed at follow-up. Thus, there were no false negative cytologic diagnoses; eight malignant diagnoses were confirmed by later histopathologic examination of the surgical biopsy. CONCLUSION: To reduce the high rate of surgical biopsies of benign male breast masses, we conclude that FNAC should be performed as a standard procedure in the clinical evaluation of male breast lesions.

Adolescent↗

PubMedDate not supplied

Diagnostic accuracy of fine needle aspiration cytology in pancreatic lesions. A review of 77 cases.

Fine needle aspiration cytologic specimens from pancreatic lesions in 77 patients were blindly reviewed. The patients were divided into two subgroups: group A included 19 patients without malignancy of the pancreas, and group B included 58 patients with confirmed malignancy (primary or secondary) of the pancreas. The original cytologic diagnoses in both groups were plotted against the respective reevaluated cytologic diagnoses. In group A there were no false-positive cytologic diagnoses, neither originally nor on reevaluation. In group B, among nine cases originally diagnosed as "benign cells," there were two cases diagnosed as malignant on reevaluation, while in the remaining seven cases malignant cells could not be found on reevaluation. In 11 cases in group B the cell material was considered insufficient for cytologic diagnosis, both originally and on reevaluation. In 34 of the 58 cases (58.6%) in group B a conclusive cytologic diagnosis of malignancy was made both in the original cytologic reports and on reevaluation. In this series, sampling errors accounted for most false-negative cytologic diagnoses. The specificity in our series was 100%. The demonstrated sensitivity was 59% initially and 62% on reevaluation.

Adult↗