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Biomedical subjects

R M Burde

Publications and source records attributed to R M Burde.

At least 91 records · Page 5Linked to original sources

Unilateral and asymmetric optic disk swelling with intracranial abnormalities.

Although asymmetric or unilateral optic disk swelling is unusual in patients with increased intracranial pressure, we treated three such patients. Two (a 31-year-old man and a 31-year-old woman, both of whom were overweight) had benign intracranial hypertension. The third patient (a 64-year-old man) had a posterior fossa mass that was later discovered to be an anaplastic astrocytoma. Thus, unilateral optic disk edema does not exclude intracranial abnormalities. The papilledema may be unilateral rather than bilateral because of an anomaly of the optic nerve sheath or a subarachnoid hemorrhage.

Adult↗

Three-dimensional topography of the central visual field. Sparing of foveal sensitivity in macular disease.

Threshold static perimetry was performed using test object patterns that covered contiguous areas of the central visual field. Computer imaging methods were used to display a three-dimensional surface that was interpolated between the sensitivity values at each of the test object locations. The examinations covered the area out to and including 10 degrees of eccentricity from the point of fixation, corresponding to the same area of the visual field covered by the Amsler grid. The normal visual field surface appears as a high plateau with a smoothly rising level of sensitivity forming a peak at the point of fixation. It was found that in a variety of macular diseases, including those caused by vascular, as well as primary degenerative disorders, central scotomas were characterized by relative sparing of visual sensitivity at the point of fixation. The pattern thus produced was one of a ring-shaped depression within the central 10 degrees of the visual field. This phenomenon was present in 20% of cases with central scotomas resulting from macular disease, but was not found in any eye of 64 patients suffering from central scotomas as a result of optic nerve disease. This pattern of visual field loss may be common, though not frequently recognized. It is proposed that the phenomenon of preservation of foveal sensitivity may be a marker for macular disease, as distinct from central visual field defects arising from optic nerve disease.

Adult↗

Beesting papillitis.

A 72-year-old, white male presented with sudden, painless loss of vision bilaterally associated with optic disc swelling. His visual loss occurred within 24 hours of receiving multiple beestings. Clinical examination revealed papillitis. Optic neuritis associated with beestings is a rare complication which is not understood fully.

Aged↗

Isolated sixth nerve palsy as initial manifestation of systemic lupus erythematosus. A case report.

A 35-year-old woman with an isolated, transient sixth cranial nerve palsy was found to have a positive fluorescent antinuclear antibody test with a pattern and titer most consistent with systemic lupus erythematosus. Mild anemia and leukopenia were also present. Over 2 months she improved without treatment. Nervous system disease in systemic lupus erythematosus and the unusual nature of presentation in this case are discussed.

Abducens Nerve↗

Anterior ischemic optic neuropathy of the young.

Anterior ischemic optic neuropathy is a well-recognized syndrome usually occurring in an older adult population. It is unusual for these patients to experience a second attack in an eye already affected. We describe three young patients with anterior ischemic optic neuropathy who have experienced repeat attacks in one or both eyes, leaving the patients severely disabled, without evidence of other ocular or systemic disease. We believe they may represent a new, but rare, syndrome.

Adult↗

The visceral nuclei of the oculomotor complex.

A series of experiments in monkeys utilizing the fluorescent tracer substances, FB and NY, injected into the ciliary ganglion have demonstrated labeling in three distinct regions in the mesencephalon: (1) the AM, (2) the NP, and (3) the EWN. Further, it was shown that the caudal extensions of the EWN reached to the level of the CCN of the somatic complex and that the LVC divided into a major and accessory column at the junction of the middle and posterior one-third of the somatic complex. The latter finding, ie, projections from the LVC to the ciliary ganglion in concert with the known connections of the retinorecipient areas in the pretectum with the visceral nuclei, allowed the formation of postulates about the reflex pupillary light pathways.

Animals↗

Autoimmune retrobulbar optic neuritis.

Three patients, all women, ranging in age from 26 to 44 years, had acute retrobulbar neuritis and laboratory evidence of a collagen vascular disorder. These patients were treated with intravenously administered "pulse" methylprednisolone, and visual acuity recovered in three of four involved eyes. Continued oral administration of prednisone and other immunosuppressive drugs was necessary to maintain vision.

Adult↗

Evaluation of the suprasellar cistern by computed tomography.

The normal suprasellar cistern is a five- or six-pointed, starshaped, fluid-filled structure as demonstrated by computerized axial tomography (CAT). At various levels the normal suprasellar cistern contains the major intracranial vessels and their anastomotic channels, the optic nerves, chiasm, and infundibular stalk. The existence of lesions, either intrinsic structures of or extrinsic structures contiguous to the suprasellar cistern can be detected by their effect on the normal anatomy of the suprasellar cistern or by filling defects produced when studied with metrizamide cisternography.

Brain↗

Atypical oculomotor paresis.

A series of patients is presented with partial oculomotor palsies. The accompanying signs of neurologic dysfunction are indicative of a mesencephalic lesion. The peculiar anatomy of the third cranial nerve permits one to infer precise localization of the lesions.

Adolescent↗

Cryptococcal meningitis. An atypical presentation.

A previously healthy 23-year-old white female presented with a history of horizontal diplopia prior to any other symptoms. Physical examination revealed bilateral sixth cranial nerve palsies, papilledema, right Horner's syndrome, and right hemiparesis. Cryptococcus neoformans was isolated from the cerebrospinal fluid. This is the first documented case of Horner's syndrome associated with cryptococcal meningitis.

Abducens Nerve↗

Terminal long arm deletion of chromosome 7 and retino-choroidal coloboma.

This communication describes a 7-year-old male with growth and psychomotor retardation and dysmorphic features who has a small terminal deletion of the long arm of chromosome 7. The proband, in addition, had bilateral coloboma of the retina and choroidea which was not reported previously in patients with this rare chromosomal deletion syndrome. Our finding and available data in the literature on the association of the coloboma of the eyes with various chromosomal abnormalities points out the importance of karyotype studies in such patients, especially in the presence of concomitant extraocular findings.

Adult↗