PubMed Health⌕ Search

Biomedical subjects

R Natusch

Publications and source records attributed to R Natusch.

At least 37 records · Page 2Linked to original sources

[Haptoglobin types and chronic glomerulonephritis].

In 88 patients a chronic glomerulonephritis was diagnosed by histology and immunohistology. The haptoglobin type was also analyzed. The distribution of the haptoglobin types in the sample did not differ from the haptoglobin distribution in the population of Berlin. The distributions of histologic and immunohistologic forms of glomerulonephritis were related to the haptoglobin distribution in our patients. The distribution of histological subgroups does not depend on the distribution of the haptoglobins. In evaluation of the immunohistological subgroups we found that immunocomplexnephritis is less frequent in the group Hp 1--1 than in the groups 2--1 and 2--2. We suppose that persons with Hp 2--1 and Hp 2--2 are prone to increased antibody formation. Hp 1--1 is presumably a blocking antibody.

Antibody Formation↗

[Selected aspects of percutaneous renal bipsy].

In connection with the complications after percutaneous renal biopsy is reported on a collecting statistics in which 16,644 renal biopsies are analysed which are performed in 51 nephrological centres of the GDR. On the basis of the same material the question was examined to what extent the frequency of biopsy has influence on the complication rate. With the help of an own investigation material of 3,122 renal biopsies the importance of the puncture of neighbour organs of the kidney is examined which with 3.3% is indeed relatively often, but is apparantly of only insignificant clinical relevance. Summarizing the contraindications of the renal biopsy are described, and the indications, issuing from the practical necessity and the importance for the patient are explained. The problem of the repeated biopsies is discussed under the aspect of the statement ability and the influence on decisive changes of therapeutic measures.

Biopsy↗

[Immunopathogenesis of glomerulonephritis].

After an introductory description of some morphological points of view the author enters into the mechanisms of the immunopathogenetic lesion in different forms of glomerulonephritis. Hereby Goodpasture's syndrome, the acute post-streptococcal nephritis, the membranoproliferative glomerulonephritis, the sclerosing forms and the so-called glomerulonephritis with minimal changes are particularly taken into consideration. It is tried to describe the clinical course and the pathomorphological changes.

Animals↗

[Clinical aspects of glomerulonephritis].

With the help of 260 bioptically ascertained cases of glomerulonephritis clinical characteristics for individual forms of glomerulonephritis are explained. Specific laboratory findings and functional tests are correlated to the bioptic findings and their valency for the individual groups of diagnosis discussed. As a result of the investigation 99% of all cases of disease may be recognized only by the examination of the urine, taking into consideration the interference of the individual symptoms.

Biopsy↗

[Treatment of glomerulonephritis].

Issuing from the importance of the glomerulonephritis and the different spontaneous course of the certain morphological forms of glomerulonephritis recommendations are given for the indication of a therapy of glomerulonephritis. For the prednisone, indomethazin, azathioprin and cyclophosphamide treatment therapeutic schemata proved in practice are recommended. The results of the therapy of 32 cases of glomerulonephritis treated with prednisone and of 125 cases treated with indomethazin are described. Two observations of a five-year-course in a rapid progressive glomerulonephritis and in a Goodpasture syndrome refer to a probably favourable therapeutic effect of azathioprin. Finally it is referred to the advantages of an additional immunofluorescence-histological examination of the renal tissue in 50 cases of glomerulonephritis observed during the course.

Anti-Glomerular Basement Membrane Disease↗

[Kidney biopsy in the differential diagnostic clarification of renal diseases in diabetic patients].

The diagnosis of arteriosclerosis is simple. The chronic pyelonephritis, however, is in most cases not clearly to be diagnosed, but only with a certain probability. To the glomerulosclerosis is applied that conspicuous findings allow of a doubtless diagnosis. But not in the least seldom there exist certain difficulties, above all in the initial stage and in the clear limitation to glomerulonephritis. In the majority of these cases the modern morphologic investigation methods lead to a clarification, but also the exact anamnestic and clinical data may be very useful for a probability diagnosis.

Arteriosclerosis↗