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R Navone

Publications and source records attributed to R Navone.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[In vitro development of macrophages from PHA-stimulated blood cultures in Hodgkin's disease and in chronic lymphocytic leukaemia (author's transl)].

Blood was cultured from 17 normal subjects, 28 cases of untreated chronic lymphocytic leukaemia (CLL) and 41 cases of Hodgkin's disease. Macrophages were not observed in PHA-stimulated cultures of normal subjects, of CLL or of 18 cases of Hodgkin's disease. The latter had an almost normal rate of lymphocyte blast transformation (70,2 +/- 7,2%).on the other hand, macrophages were numerous in PHA-stimulated cultures of 23 cases of Hodgkin's disease with a low blast transformation (28.4 +/- 13,7%). In Hodgkin's disease the development of macrophages in PHA cultures may be related to the lower blast transformation and cytotoxic activity of lymphocytes. In CLL the dilution of lymphocytes and monocytes by leukaemic B cells may account both for PHA unresponsiveness and low yield of macrophages in culture.

Antibody Formation↗
PubMedDate not supplied

High prognostic impact of growth fraction parameters in advanced stage laryngeal squamous cell carcinoma.

One hundred and two cases of laryngeal squamous cell carcinoma, all treated in the same center with total or supraglottic laryngectomy, bilateral neck dissection and postoperative radiotherapy, were investigated with both Ki67 and MIB-1 monoclonal antibodies. The aim was to determine the prognostic impact of growth fraction markers in a homogeneous series of patients. All samples were stained with Ki67 monoclonal antibody on frozen sections, and with MIB-1 monoclonal antibody on paraffin sections, using the ABC immunoperoxidase method. The percentage of positive cells was compared in each case with the overall and disease-free survival, pathologic stage and histologic grading. The values obtained from Ki67 and MIB-1 counts were similar and highly correlated (r=0.90). Two groups of cases with low and high proliferation rate (59 and 43 respectively) were obtained by splitting up the whole series, on the basis of the median value; 84. 6% of the patients with high proliferation relapsed and/or died due to the tumor within two years from diagnosis whereas, at time of writing, 94% of the patients with low proliferation are alive and well (p<0.00001). No relation was found between growth fraction and histologic grading, pathologic stage (pT and pN) and site of the tumor. Only lymph node involvement was correlated with disease-free survival. Our results indicate that Ki67/MIB-1 index represents an independent variable to determine long-term prognosis in laryngeal squamous cell carcinomas. We recommend its use in diagnostic protocols, to distinguish high risk subsets of patients who might benefit from more aggressive treatments.

Adult↗
PubMedDate not supplied

[Evolution of acute leukemia in myelodysplastic syndromes: prognostic histopathological factors in a series of bone marrow biopsies].

Out of 9,324 bone marrow biopsies, 250 cases of myelodysplastic syndromes (MDS) and 514 of acute non-lymphoid leukemia (AL) were collected. Twenty AL represented an evolution of MDS: the marrow had a mean cellularity of 58.5%, a mean percentage of blasts of 19% (55% of the cases had more than 10% of blasts in the marrow); only in one case (5%) benign lymphoid nodules (LN) were present. In 42 cases of MDS deceased without an evolution to overt AL, the bone marrow showed a cellularity of 60%, a mean percentage of blasts of 14% (only 29% had more than 10% of blasts); in 13 cases (31%) LN were present. Our data indicate that the percentage of bone marrow blasts is the most significant criterion for predicting an evolution to AL, although in the single case such evolution is not foreseeable. The presence of LN mostly in MDS without a leukemic progression could indicate a protective effect of NL, perhaps by means of an immunologic mechanism.

Acute Disease↗
PubMedDate not supplied

Bone marrow involvement in Kaposi's disease. Report of a case.

A 71-year-old woman with Kaposi's sarcoma was admitted to the hospital because of severe pancytopenia with negative sternal aspirate. The bone marrow trephine biopsy demonstrated an extensive replacement of the hematopoietic tissue by Kaposi's sarcoma. Skin, soft palate mucosa, spleen, retroperitoneal and axillary lymph nodes were also found to be involved at the post-mortem examination. Therefore the bone marrow biopsy can be used in the staging of Kaposi's sarcoma in presence of pancytopenia and might be able to detect a primary visceral involvement in patients without cutaneous lesions.

Aged↗