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Biomedical subjects

R O Greer

Publications and source records attributed to R O Greer.

53 records · Page 3Linked to original sources

Oral focal acantholytic dyskeratosis (warty dyskeratoma). Report of two cases.

Two cases of intraoral focal acantholytic dyskeratosis are presented. These uncommon, small, nodular, keratotic lesions, with a distinct histologic pattern similar to that of Darier's disease, have been reported as warty dyskeratomas. Treatment is conservative surgical removal and follow-up. It is suggested that the histologic diagnostic term of focal acantholytic dyskeratosis be used, since there may be several clinical entities with a similar histology but different etiology.

Acantholysis↗

Studies concerning the hsitotoxicity of isobutyl-2-cyanoacrylate tissue adhesive when employed as an oral hemostat.

An experimental study was implemented to determine the effectiveness of isobutyl-2-cyanoacrylate (bucrylate) as an oral hemostat, its influence on sequential wound healing, and its potential as a carcinogen. Segregated groups of equal numbers of male and female Long-Evans Hooded Rats underwent deep (socket) and superficial (surface) aerosol placement of bucrylate to maxillary molar extraction sites. Bucrylate proved to be an effective oral hemostat, rapidly retarding postextraction hemorrhage. Deep placement of the adhesive resulted in retarding of healing and lingering macrohistiocytic aggregates in wounds. Superficial placement of the material resulted in very little long-term macrohistiocytic response, and would healing showed little retardation. A neoplastic potential was not demonstrated for bucrylate.

Aerosols↗

A comparison of the use of smokeless tobacco in rural and urban teenagers.

This paper compared the use of smokeless tobacco and its effects in rural and urban teenagers. A random sample of 445 subjects from rural Colorado were examined: 82.9 percent of the total sample were Caucasian, and 94.6 percent of those who used smokeless tobacco were Caucasian. This percentage supports the findings of an earlier urban study that the habit is predominantly one of male Caucasians. The average age of the users was 16.7 years, slightly older than in the urban study. Of the rural users, 62.5 percent had lesions of the oral tissues, compared with 48.7 percent lesional incidence in urban users. In both studies, those subjects with lesions had longer daily contact with smokeless tobacco, as well as a longer history of use than those without lesions. These are numerical averages that reflect great individual variations in susceptibility. The average duration of use for rural and urban users with lesions was almost the same; the development of lesions appears to be related to the length of daily exposure, which, on the average, was greater among rural users than urban users. Additionally, more than twice as many degree 3 lesions were found among users in the rural study. The habituating effects of nicotine and the influence of this substance on the future tobacco-usage patterns of youngsters who presently use smokeless tobacco are areas of concern. It is hoped that additional research will further delineate the scope of this current health problem.

Adolescent↗

Vertical guided bone-graft augmentation in a new canine mandibular model.

Using the mandibular inferior border of four fox hounds from an extraoral approach, six high-profile Brånemark implants were placed in each animal and bone grafted. Graft materials studied included demineralized freeze-dried allograft with and without irradiation sterilization (3.8 x 10(4) Gy), corticocancellous iliac autograft, blood clot, and a control. Corticocancellous grafts were studied with and without expanded polytetrafluoroethylene (EPTFE) barriers. The barrier function improved both graft volume incorporated and bone-implant interface contact. The autograft performed better than the allograft. Irradiation of the allograft did not appear to affect graft performance. The barrier functioned to improve graft incorporation for augmentation and interface contact and gives credence to the use of barriers in conjunction with vertical augmentation grafting of jawbone.

Alveolar Bone Loss↗