[Evolution of antibodies during experimental bilharziasis in the rabbit infested with Schistosoma mansoni].
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Biomedical subjects
Publications and source records attributed to R Pautrizel.
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The author studies the significance of intestinal bilharziosis in Guadeloupe. Immunologic methods have been used because of their greater sensitivity: a complement fixation micromethod using a delipidated antigen is described. The study of about 8,500 sera taken in various areas showed the significance of bilharziosis: the mean level of positive sera was 35%, a figure much higher than those obtained with parasitologic methods. The percentage observed in the various regions showed sometimes very great differences, which may be explained by various factors, the most important ones being the population density, the disposition of the hydrographic network and its relationships with habitat. Such a study, if it could be carried out during the next years, should allow to appreciate the efficiency of the control measures of the endemia.
A study of 4,600 sera by means of a micro-method of complement fixation with a delipidated antigen allowed to evaluate the significance of intestinal bilharziosis at la Martinique and to precise its geographical distribution in the various areas of the island. The mean infestation ratio (about 27 0/0) is much higher than that obtained with parasitologic techniques; it confirms the great sensitivity of immunological methods and the high percentage of infested people in these areas. On the other hand the study of infestation ratio in the various places shows the role played by the hydrographic system and its relationship with the habitat: a fundamental opposition is observed between two areas: the North of the island, which is damp, with many rivers and highly infested, and the South, dry, with a much lower infestation ratio.
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Mice infested with Schistosoma mansoni are kept continuously in an ambiant temperature of 35 degrees C for different periods and at different stages of the infestation. The effects of the hyperthermia thus provoked are evaluated by counting adult parasites and pulmonary schistosomules. There is a very considerable decrease in the number of parasites present, probably due to the action of the higher temperature on the early migratory phase of the schistosomules.