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Biomedical subjects

R R Chaudhury

Publications and source records attributed to R R Chaudhury.

At least 37 records · Page 2Linked to original sources
PubMed1980

Enhanced antipyrine metabolism in cigarette smokers in Indian population.

A single oral dose of mg/kg body weight of antipyrine was administered to 10 chronic cigarette smokers and to 9 appropriate control healthy volunteers. Plasma antipyrine half-life (t 1/2 beta) was shortened significantly (p < 0.05) in cigarette smokers as compared to the non-smokers control group. Antipyrine was cleared from the blood faster in cigarette smokers, with a mean increase in metabolic clearance rate from 0.637 ml/min/kg in nonsmokers to 0.831 ml/min/kg in cigarette smokers. Concern as to enhanced metabolism of other drugs is probably warranted in cigarette smokers.

Adult↗
PubMed1979

Relationship between prostaglandins and cyclic-AMP in the process of implantation in rats.

The effect of alloxan, a known inhibitor of adenylate cyclase, on the levels of prostaglandins E and F was investigated in pregnant rats. Animals were treated intraluminally with alloxan in normal saline or alloxan plus cyclic-AMP in normal saline or normal saline alone on day 4 of pregnancy. The uteri were collected on days 5 and 6 of pregnancy and the prostaglandins E and F were extracted and measured by a radioimmunoassay technique. In the alloxan treated rats, a significant reduction in PGE and PGF levels was found on days 5 and 6 of pregnancy as compared to untreated control group, whereas in the alloxan plus cyclic-AMP treated group the levels of PGE and PGF were comparable to those of the untreated control group. These findings suggest a possible relationship between prostaglandins and cyclic-AMP in the process of implantation in rats.

Alloxan↗
PubMed1977

The release of prolactin by medroxy-progesterone acetate in human subjects.

Medroxyprogesterone acetate an injectable contraceptive when administered to four lactating women at a dose of 150 mg every three months significantly raised prolactin levels over those observed in four control women. Prolactin levels were higher at all times during 4-17 weeks in the drug-treated women, irrespective of whether the samples were collected before or after suckling. It was also observed that while suckling clearly released prolactin in both groups the difference was greater in the women receiving the injection, indicating that the drug enhanced the release of prolactin in response to the suckling stimulus.

Adult↗
PubMed1976

The effect of D-norgestrel, 30 micrograms, on the oral glucose tolerance test, including insulin levels, in Thai women.

The effect of D-norgestrel, 30 mug, on the oral glucose tolerance test was studied in 49 Thai women. There was a significant elevation of the blood glucose level at 60 minutes during the test in women who had taken D-norgestrel for 6 and 12 months. Insulin levels in the blood were significantly elevated over control levels in both groups of women at 90, 120, 150, and 180 minutes during the test. There was no difference in the results obtained at 6 months and 12 months. There was also no significant difference in the fasting blood glucose or insulin levels in the three groups of women. The results indicate that D-norestrel at a daily dose of 30 mug has an effect on carbohydrate metabolism in Thai women.

Administration, Oral↗
PubMed1972

Metabolic effects of contraceptive steroids. III. Intravenous glucose tolerance--short term observations.

Intravenous glucose tolerance tests were carried out in women taking 2 types of estrogen/progestogen combination oral contraceptives. Each subject had the test done on days 18-21 in a control cycle before the medication was begun and 3 consecutive cycles during administration of the drug. Fasting blood glucose levels and K values showed no significant changes with a combination of megestrol acetate (4 mg) with 0.05 mg of ethinyl estradiol. A significant decline in glucose tolerance was observed by the change in K values during all 3 cycles of medication with a combination of 2.5 mg lynestrenol and 0.075 mg mestranol. Tests repeated 2 months after stoppage of the medication in 5 subjects showed that blood sugar levels and K values had returned to pretreatment levels.

Age Factors↗