Biomedical subjects

R Radev

Publications and source records attributed to R Radev.

At least 19 recordsLinked to original sources

PubMed1991

[Changes in body temperature during anesthesia].

The skin and esophageal temperature was investigated in 60 pregnant women on whom Cesarian section (cs) was performed. The patients were divided into four groups randomly in accordance with the type of anaesthesia. It was found that general, epidural and spinal anaesthesia during elective Cesarian section did not disturb thermal balance of the pregnant woman and parturient. The indicated types of anaesthesia did not have negative influence on the skin and esophageal temperature. The induced vasodilation of epidural and spinal anaesthesia caused an increase in the skin temperature with 1.7% of the initial values.

Anesthesia, Endotracheal↗

PubMed1991

[A comparison between thiopental, midazolam-ketalar and midazolam-ketalar-aneksat for anesthesia during cesarean section].

The effect of dormicum-ketalar and dormicum-ketalar-anexat in comparison with thiopental was studied on 45 parturients at 39-40 weeks' pregnancy, operated electively, divided into three groups as each group consisted of 15 women. The representative groups were compared by the following parameters: duration of the operation, age, weight, duration of induction in anaesthesia-extraction of the fetus, premedication, anaesthesia after the extraction of the fetus. Usage of dormicum ketalar for induction in anaesthesia during cesarean section did not affect the basic metabolic parameters of the parturients, fetus and amniotic fluid. Such a combination of preparations during simultaneous neutralization of the action of dormicum by anexat affects positively the fetal state, transport of O2 and activity of enzymes, in order that the fetus could survive more favourably this critical state.

Anesthesia, Obstetrical↗

PubMed1991

[Morphological changes in experimental duodenogastric reflux].

The model of a total duodenal-gastric reflux was developed in 20 dogs and morphological changes in the stomach were studied. 5 dogs served as control. Histologic changes occurred 3.5 months and 1 year after the operation were characterized by metachromasia, increased mucus formation, proliferation of epithelial and parietal cells, moderate inflammation. Process of the disease had fluctuations. 6 months after the operation 5 dogs were reoperated for the elimination of reflux and were observed for another 6 months. A complete reversibility of all changes was established. Bacteriological studies showed a considerable increase of bacteria population in the stomach and a pH increase. The authors suggest the term 'reflux gastropathy" to replace the term "alkaline reflux-gastritis".

Animals↗

PubMed1990

[The function of the hepatobiliary system in patients who have had inflammatory diseases of the uterus and adnexa].

The function of the hepatobiliary system was studied on 60 women, undergone inflammatory diseases in the uterus and adnexa. The women of the basic group (n = 60) were divided into two subgroups in accordance with the state of genital organs. The first subgroup (n = 39) included women with residual manifestation of chronic salpingo-oophoritis. The second subgroup (n = 21) included women with tumours and tumour-like processes of genital organs, occurred on the back ground of a continuous inflammatory process. The control group included 10 healthy women. Dynamic scintigraphy of the liver and gallbladder utilizing Tc99 radionuclide with short duration of life, was used to determine the functional state of the liver and gallbladder together with biochemical parameters of blood. The obtained results showed that there were significant changes in hepatobiliary system of women with residual manifestations of chronic salpingo-oophoritis. In women with tumours and tumour-like processes of genitals, occurred on the background of continuous inflammatory process, there were significant disturbances in the engulfing-depurating function of the liver and gallbladder of hypokinetic type.

Adult↗

PubMed1990

[Uterine contractile activity in the postoperative period depending on the type of anesthesia].

The functional state of the uterus was studied on 75 parturients, divided into the following groups: a control group of 20 women with normal delivery, first group of 35 parturients with cesarean section anaesthetized by the method of ataralgesia and second group of 20 parturients with cesarean section anaesthetized by the method of neuroleptanaesthesia. The level of the enzyme oxytocinase was determined in sera of parturients. Contractile activity of the uterus during the postoperative period did not depend on the type of anaesthesia. It was established statistically significantly (p less than 0.05) that the combination (metacine, dimidrol, droperidol and phentanyl)--second group, had inhibitory effect on the efficient and rhythmic activity of the uterus in comparison with parturients of the first group (alcosine, diazepam and phentanyl).

Analgesia, Obstetrical↗

PubMed1989

[Prevention of aspiration syndrome in general anesthesia].

In 210 patients divided in 7 groups depending on surgical disease or pregnancy the authors estimated pH of the gastric content during the preoperative period. It was found that pH was below 2.5, i.e. the acid level of the gastric content was high enough to present a hazard for appearance of Mendelson's syndrome, should eventual regurgitation or aspiration occur during or after general anesthesia. In an effort to prevent aspiration syndrome, apart from the most reliable and well know precaution "empty stomach", the authors suggest premedication with antacid drugs before the operation. They have applied Almagel A or Cimetidin 30 min before the operative intervention. The acid level of the gastric juice was thus reduced for about 1 1/2 hours to pH levels higher than the critical 3.5, so that in the event of eventual regurgitation and aspiration the gastric content would not cause severe respiratory injury. With their suggestion for use of antacid drugs during the preoperative period the authors expand the preoperative preparation of the patient for general anesthesia with set purpose to prevent respiration (Mendelson's) syndrome.

Aluminum Hydroxide↗

PubMed1989

[Enzyme activity in the blood serum and lymphocytes of patients with chronic salpingo-oophoritis combined with benign tumors of the genitalia].

The activity of some enzymes was examined in blood serum and lymphocytes of women with chronic salpingo-oophoritis in combination with tumourous processes of the genital organs. The objects of the study were 96 women, divided into three groups: first group (control)-20 healthy women, second group-37 women with chronic salpingo-oophoritis and third group-39 women, who suffered from chronic salpingo-oophoritis together with tumours and tumourous processes of genital organs-uterine myoma, endometriosis, cysts and cystomas of the ovaries. The studies showed that in women with continuous course of inflammatory processes there were phenomena in the lymphocytes characteristic of tension of adaptation-compensatory reactions, but inhibition and lowering of the activity of energy metabolism was observed in women with tumours and tumourous processes at the same time. Lymphocyte acid phosphatase, asparataminotransferase, hydroxy-butiratdehydrogenase and lactatdehydrogenase appears to be a prognostic sign for early discovery of features of tumourous process in the female organism on the background of chronic inflammatory process of genital organs.

Adult↗

PubMed1989

[Dynamic biochemical indices of parturients with uterine inertia against a background of hyperbaric oxygen and drug treatment].

Acid-base balance, lactate dehydrogenase, creatine phosphokinase, hydroxybutyrate dehydrogenase, oxytocinase and the final products of peroxide oxygenation of lipids-malonate dialdehyde and antioxidant activity were studied on 60 parturients, divided into two groups as each group had 30 women. Hyperbaric oxygen treatment in combination with oxytocin was studied on uterine inertia. The control group consisted of 20 parturients with normal course of delivery.

Acid-Base Equilibrium↗

PubMed1989

[Changes in the central and peripheral hemodynamics during combined electroanalgesia (CEA) during gynecological operations].

Central and peripheral hemodynamics was examined in 180 women with gynecological diseases, divided into the following groups: 130 women of the basic group, operated under the conditions of combined electroanalgesia, and 50 women of the other group, operated under the conditions of combined endotracheal anesthesia, using the preparations droperidol and phentanyl. Both central and peripheral hemodynamics in both groups were characterized by stability at all stages of the operation. Both types of anesthesia protect reliably the organism from operative trauma. The concentration of cortisol in both groups presented values higher than the initial values before premedication, which proved that adequate reaction of the organism was preserved during operation under the conditions of anesthesia.

Adult↗

PubMed1988