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R Radev

Publications and source records attributed to R Radev.

25 records · Page 2Linked to original sources
PubMed1976

[Electrophysiological aspects in the mechanism of action of some psychotropic drug agents].

On the basis of the experiments on animals the author made an attempt to find out the place of the action of some psychotropic drugs on the central nervous system and to discover the changes, which occurred in the functional state of various cerebral structures. He used drugs Imupramine (Psychoforin) and Diazepan (Valium), administered localy in some structures of the lymbic system and reticular formation of the cat cerebrum, using stereotaxic technique. The evaluation of the occurred changes was made by the changes in the spontaneous and induced cerebral activity, using the method of double stimuli. The obtained results gave foundation to state that drugs with antidepresive action (Imipramin) inhibited amigdalic complex and the structures connected with it, but benzodiazepines (Diazepam) revealed this action also on the mesencephalic reticular formation as the structures, brocked by the antidepresants, were not affected. In conclusion an electrophysilogic argumentation was made for the combined application of both groups of preparations in neurotic patients.

Amygdala↗
PubMed1975

[Effect of beta-adrenergic blockaders on the bioelectrical activity of the mesenchephalic reticular formation].

The authors examined the beta-adrenergic structures in the mesencephalic formation (MSF) in view of establishing their role on the activity of MSF in view of establishing the in rols on the activity of MSF itself and the relationship of the same formation with the cerebral cortex and the lymbic system. It was established that beta-adrenergic blockers after their local application in MSF could inhibit its function. The data from the effect on the induced bioelectrical activity indicated also diminution in the functional activity of MSF. The authors found that the inhibiting influences of beta-blockers were abolished by their antagonist isoprenalite. An inference is made that there are beta-adrenergic structures, which act excitatory.

Adrenergic beta-Antagonists↗