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Biomedical subjects

R Shibata

Publications and source records attributed to R Shibata.

136 records · Page 8Linked to original sources
PubMed1979

Diagnostic and prognostic significance of electroencephalography with intravenous diazepam in epilepsy.

Thirty cases of intractable epilepsy in children were investigated to observe the correlation between the suppression of seizure discharges to intravenous diazepam and the type of seizure or effects of subsequent therapy. Suppression of seizure discharges were bilaterally poor in 75% of the cases with infantile spasms and 89% of cases with Lennox syndrome and other generalized seizures while it was unilaterally poor in 80% of the cases with focal or unilateral seizures. ACTH or steroid therapy was clinically and electroencephalographically effective in 80% of the cases with good suppression responses and in none of cases with good suppression that was resistant to the therapy. On the other hand, clinical seizures were not controlled in 73% of the cases showing poor suppression and EEG did not reveal improvement in 82% of the cases with poor suppression. EEG with intravenous diazepam is valuable for understanding the pharmacophysiological mechanism of epilepsy and it may be possible to select cases as candidates for ACTH or steroid therapy using this technique.

Adrenocorticotropic Hormone↗
PubMed1978

A sensitive solid phase radioimmunoassay for secretory IgA: its application for the determination of urinary levels of secretory IgA in children and adults.

A sensitive solid phase radioimmunoassay method was established for the specific quantitative determination of secretory IgA (sIgA) by taking advantage of the dual antigenicities of sIgA, one specific for alpha-chain and the other for secretory component (SC). The sIgA and IgA in the sample were first bound by anti-IgA antibodies coated on the polystyrene tube, then the amount of bound sIgA was quantified by the use of 125I-labeled anti-SC antibodies. This method is quite sensitive and allows us to distinguish sIgA from IgA and free SC which usually coexist in exocrine secretions. Linear relationship was observed between the bound radioactivity of radioiodinated anti-SC and the amount of sIgA in the range of 5 to 60 ng of sIgA. With this method, the urinary sIgA levels in normal children and adults were measured. Urinary sIgA was detected in half of infants within 7 days after birth, while it could be demonstrated in almost all of the infants by 14th day. Then, it gradually increased and reached about a half of the adult level by the age of puberty. This method will be useful for the sensitive and specific measurement of sIgA in various exocrine secretions.

Adolescent↗
PubMedDate not supplied

CM3, one of the wheat alpha-amylase inhibitor subunits, and binding of IgE in sera from Japanese with atopic dermatitis related to wheat.

The purpose of the present study was to determine whether wheat alpha-amylase inhibitor subunits bind IgE sera from Japanese with atopic dermatitis (AD) related to wheat. IgE in sera from eight out of the 11 patients with RAST value of 3 or 4 against wheat-bound salt-soluble proteins of wheat and the alpha-amylase inhibitor proteins separated by gel filtration chromatography. The subunits of tetrameric alpha-amylase inhibitor, CM2, CM3 and CM16 (molecular weight approximately 14 kd), known to be major allergens for baker's asthma, were purified. Then the binding activity to IgE sera from the AD patients was examined by immunoblotting. The IgE sera bound only to CM3, not to CM2 and CM16. These results suggest that CM3 may be involved in both atopic dermatitis and baker's asthma.

Adolescent↗
PubMedDate not supplied

The cervical aortic arch with aneurysm formation.

An asymptomatic 59-year-old man was admitted with an initial suspicion of mediastinal tumor. He was diagnosed as having a left-sided cervical aortic arch (Haughton type D) with arch aneurysm by using contrast-enhanced CT and angiography. The arch aneurysm was surgically removed. This is the 20th reported case of cervical aortic arch with aneurysm formation.

Angiography↗
PubMedDate not supplied

Extensive surgery for primary malignant lymphoma of the heart.

The surgical treatment of primary malignant lymphoma of the heart in a 43-year-old man is reported. The tumor was extensively resected together with the right atrial wall and both venae cavae, and the resulting defect was repaired with a bovine pericardial patch. The postoperative course was fairly stable for more than 7 months following surgery, under a regular chemotherapy regimen. The patient died of acute pneumonia on the 234th postoperative day. The autopsy findings confirmed the diagnosis of primary malignant lymphoma of the heart.

Adult↗