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Biomedical subjects

R Slifkin

Publications and source records attributed to R Slifkin.

4 recordsLinked to original sources
PubMed1979

A wearable artificial glomerulus.

We have shown that hemofiltration can be conducted for 16 hrs/day for more than 3 continuous days by connecting an Amicon 0.2 M2 hemofilter to an arteriovenous shunt. We can produce over 8 ml/min of ultrafiltrate with no external pump, and this ultrafiltrate can be replaced by having the patient drink an electrolyte-glucose solution. Anticoagulation can be attained with heparin, warfarin and cyproheptadine. Each filter can be expected to function at least 48 hrs before it must be replaced.

Filtration↗
PubMed1977

Persistent immunoglobulinuria in irreversible renal allograft rejection in humans.

To evaluate the extent of injury in short- and long-term renal allografts, the urinary excretion of IgG, IgA, and IgM was observed during acute rejection crisis. In reversible rejection, treatment resulted in prompt correction of immunoglobulinuria, whereas in irreversible crisis urinary immunoglobulin levels continuously increased in spite of the same antirejection treatment. A good prognosis in long-term allografts was shown by low levels of immunoglobulinuria; unstable graft function had higher levels. Immunoglobulinuria can be used as an additional test to evaluate the reversibility of acute rejection, and also has significance in the long-term situation.

Adult↗