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Biomedical subjects

R Soto

Publications and source records attributed to R Soto.

At least 55 records · Page 3Linked to original sources
PubMed1982

The cardiovascular effects of acute hypoxemia as a diagnostic aid.

Acute hypoxemia produces opposite effects on the pulmonary and systemic vascular resistance. To assess the influence of acute hypoxemia on cardiac murmurs, 36 patients with a single valvular or congenital heart lesion were studied. As expected from these hemodynamic effects, right-sided regurgitant type murmurs increased in intensity during acute hypoxemia, while stenotic type murmurs were reduced. In contrast, left-sided murmurs remained constant or changed in opposite direction to their equivalent type from the right side. Additionally, acute hypoxemia produced a marked reduction of the murmurs due to left-to-right shunts and allowed an adequate differentiation of the murmurs due to ventricular septal defect from those due to mitral incompetence.

Adolescent↗
PubMed1982

Experimental superimposed infection of the hamster with Leishmania mexicana and L. braziliensis.

Hamsters inoculated subcutaneously with Leishmania mexicana (L. m. amazonensis or L. m. mexicana) and with L. braziliensis panamensis, either simultaneously or with an interval, in different parts of the body (right front paw and nose), showed an independent course of infection for either parasite with the typical clinical and histopathological characteristics produced by these organisms. In one group of animals, metastases from the paw (L. m. amazonensis) to the nose (L. b. panamensis) was proven and the partial transformation of the granuloma from epithelioid and giant multinuclear cells (tuberculoid) to histiocytes full of parasites (lepromatous), was observed. These two specific contrasting reactions, are confined to the place of infection and influenced by the type of parasite. The histopathological picture normally observed in hamsters as a reaction to L. mexicana s.1., occurs only occasionally in humans. It is suggested, on the basis of this animal model, that DCL in the New World is only produced by parasites of the "mexicana" complex and that both parasite characteristics and host immune status are responsible for this phenomenon.

Animals↗