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R Spaić

Publications and source records attributed to R Spaić.

24 records · Page 2Linked to original sources
PubMedDate not supplied

[Mechanisms of the favorable effect of spinal anesthesia in traumatic shock].

Changes in the level of total peptidoleukotriens-pLT (LTC4 + LTD4 + LTE4) and inositol triphosphates (IP3) were analyzed in the thalamus of rats subjected to "tourniquet" trauma of both hind extremities (LD50) depending on the power of afferent nociceptive nerve impulses. Prevention of spreading, i.e., reduction of painful impulses from the damaged regions was achieved by the spinal anesthesia with bupivacain-chloride immediately after removal of the rubber bandage. Together with pLT and IP3 levels determined by radio immunoassay, physiologic parameters (mean arterial pressure, blood-brain barrier permeability) were also analyzed. Morphologic changes in the thalamus of rats were analyzed by electron microscopy. Extreme increase of the thalamic pLT and IP3 levels in traumatized animals together with increased blood-brain barrier permeability were found. Spinal anesthesia prevented, i.e., reduced these pathologic changes. Authors conclude that afferent painful impulses cause pLT increase in the thalamus and could modify CNS response to the trauma.

Anesthesia, Spinal↗
PubMedDate not supplied

Assessment of osteogenic potential of the natural origin bioceramics implanted into the human infrabony periodontal defects.

The osteogenic potential of natural origin bioceramics implanted in human periodontal infrabony defects was investigated Histologic and electron-microscopic analyses of implants 3 and 4.5 months after implantation were used for the estimation of osteogenic potential. Results show that the bioceramics of natural origin with a microstructure and canalicular system of the natural bone has a strong osteogenic potential. Results of histologic and electron-microscopic analyses, performed four and half months after implantation, show that new bone has been formed in the places of absorbed or partially absorbed implant granules as also in the pores of implant granules. Histological structure of the newly-formed bone correspond to the structure of the matured lamellated bone.

Biocompatible Materials↗
PubMedDate not supplied

[Etiologic factors which affect the development of infrabony periodontal defects].

The aim of the study was to examine frequency and distribution of etiologic factors which, associated with chronic inflammation, can influence the forming of intrabony periodontal defects. The following were studied: occlusal trauma, erosions and concrements on the roots, tooth malposition, the absence of contact point, inadequate interproximal distance of roots and iatrogenic factors. The results revealed that the most frequent etiologic factor in the forming of intrabony periodontal defects was occlusal trauma--55.8%, erosion of the roots--38% and concrements in the roots--34%, as tooth malposition, inadequate interproximal distances of the roots, the absence of contact point and iatrogenic factors. In the forming of 23.5% of intrabony periodontal defects two or more of the studied factors pariticipated. By the analysis of the distribution of etiologic factors by jaw segments, it was concluded that occlusal trauma was the most frequent in upper incisors--61.6%. In upper premolars the most frequent factor was the erosion on the roots--75%, and in the upper molars iatrogenic factors and erosion of the roots--44.4%. In the lower incisors, occlusal trauma was the most frequent--62.5%, in premolars also trauma--35.7%, and concrements of the molars--64.2%. Considering the high incidence the factors associated with chronic inflammation can be extremely significant in the forming of intrabony periodontal defects during parodontopahty.

Alveolar Bone Loss↗