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Biomedical subjects

R T Schweizer

Publications and source records attributed to R T Schweizer.

At least 73 records · Page 4Linked to original sources
PubMed1985

Neonatal tolerance increases efficacy of antisera production.

In this investigation we demonstrate that neonatal tolerance can be used to increase the specificity of antisera. We have shown that if mice are immunized with a human B cell line then the antisera they produce also reacts strongly with human T cells. However, if the mice are first neonatally tolerized to a human T cell line and then immunized with the B cell line the antisera becomes much more specific for the B cell line. In theory this approach, of initially tolerizing the animal to uninteresting antigens, may also make it possible to produce monoclonal antibodies to rare cellular determinants more efficiently.

Animals↗
PubMed1984

Prophylaxis of oral candidiasis with clotrimazole troches.

Oropharyngeal candidiasis is frequently a complication of patients with altered immune states. Clotrimazole troches are effective in the treatment of Candida and were evaluated in this study in a prophylaxis regimen. Patients with malignant neoplasms who were receiving chemotherapy and renal transplant recipients who were receiving immunosuppressives were randomized to receive either clotrimazole (10 mg) or placebo troches three times a day in a prospective, double-blinded study. Eighty-four patients were randomized into the study, 18 patients with leukemia, 19 patients with malignant neoplasms, and 47 patients with renal transplants. Among all patients, thrush developed in 57% while receiving placebo compared with 13% while receiving clotrimazole prophylaxis. Prophylaxis showed significant benefit for the renal transplant recipients and for patients with solid malignant neoplasms, but not for the leukemic patients. Clotrimazole troches are effective in preventing oral candidiasis in a select group of patients.

Administration, Oral↗
PubMed1983

Kidney preservation failure using combined Collins' solution and plasma perfusion.

High levels of magnesium can reverse the anticoagulation of cryoprecipitated plasma (CPP), resulting in fibrin formation. When pig cadaver kidneys were flushed with Collins' C2 solution containing a high concentration of magnesium, clotting of CPP perfusate occurred when the CPP initial magnesium level was high, but not with low magnesium levels. Flushing with C2 and preservation with an albumin perfusate, or flushing with Ringer's solution before CPP perfusion, did not result in fibrin formation. Small amounts of heparin added to CPP did not prevent fibrin formation. C2-preserved kidneys should not be additionally preserved with CPP perfusion preservation without special consideration of magnesium levels.

Animals↗
PubMed1982

Renal allograft failure and cold red blood cell autoagglutinins.

Ten patients in a retrospective review of 250 kidney transplant recipients had RBC-cold agglutinins reactive at 22 C. Fourteen transplants were performed in those 10 patients. Five of nine cold renal allografts failed to function. Two of these recipients later had successful transplants when the kidneys were warmed before reestablishment of blood flow. Three other patients with cold RBC autoagglutinins had immediate renal function when the transplanted kidneys were warmed. In a prospective study of 126 patients, 59% had cold RBC agglutinins at 4 C and 11% were alos reactive at 22 C. Red blood cell-cold autoagglutinins appear to be a preventable cause of acute renal allograft failure. The titer and thermal amplitude of these antibodies are probably of major importance and should always be determined before organ transplantation.

Adult↗
PubMed1981

In situ cadaver kidney perfusion: experimental and clinical studies.

Lactated Ringers and Collins C2 solutions were compared in different volumes for rapid intra-aortic in situ cooling of pig cadaver kidneys. Both solutions in large volumes caused renal damage when compared with ex vivo flushed controls, although C2 was less injurious. When used for in situ cooling of human cadaver kidneys in volumes less than 1,500 ml/kidney, the two solutions were comparable and did not cause injury when compared with controls. In situ cooling permitted longer excision time (cold ischemia) and is recommended for lessening warm ischemia time in selected cases.

Animals↗