Biomedical subjects
Publications and source records attributed to R Tomecki.
The authors describe the first in Poland case of liver retransplantation in an adult recipient, in whom the indication for the procedure was bile duct necrosis following liver transplantation due to liver cirrhosis of an uncertain origin.
Surgical treatment of an early enough diagnosed large bowel cancer is possible in the screening tests. Fibrosigmoidoscopy is a sensitive method of the neoplastic lesions' diagnostics in the distal large bowel and competes the tests for occult blood in stools. The aim of the study was the assessment of fibrosigmoidoscopy as a screening test in a hospitalized patients. 2405 hospitalized patients were analysed in 2 years. Fibrosigmoidoscopy was performed in 903. Polyps, mainly neoplastic were diagnosed in 115 patients and cancers in 4 cases. The percentage of the results in other countries. The acceptance of the method was high (86%). We suggest that fibrosigmoidoscopy should be performed as the screening test in the hospitalized population.
Multicentre study was carried out in three regions of Poland aimed to assess cholecystolithiasis incidence in urban population and some potential risk factors of the disease. 10133 persons in five age groups, from 16 to 70 (6071 women and 4062 men) were examined. The examination consisted of questionnaire considered sex, age, weight, dietary habits, complaints, chronic drugs use, family history and in women number of pregnancies and deliveries as well as hormone therapy. The results obtained were analysed statistically with Chi 2 test. Cholecystolithiasis was found in 1411 persons (10.7%), among them 18% women (1083 women) and 8.2% men (328 men). Incidence rate was 180.5/1000 women and 82.0/1000 men. The obtained increase in percentage of cholecystolithiasis cases with age was statistically significant. No relation were found between the number of stones and sex of the examined persons. In 1480 persons (43.5%0 the disease was asymptotic. The studies did not prove the correlation between cholecystolithiasis in women and sex of the first child or oral contraception. Positive correlation was found between cholecystolithiasis in women, obesity, number of pregnancies and family history. In men age was most significant risk factor. Incidence of cholecystolithiasis in Poland, Western Europe and USA is similar.
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The formation of carcinoma in the hyperplastic gastric polyp is extremely rare. This paper presents two cases of carcinomas which developed in hyperplastic polyps of the stomach in a 39-year-old man and an 82-year-old man. The problem of malignant transformation of gastric hyperplastic polyps is stressed and discussed in the light of data in the literature.
The aim of this study was to determine serum retinol levels in patients with inflammatory bowel disease and to attempt to elucidate the mechanism of changes in vitamin A metabolism in these disorders. It was found that in 15 patients with active ulcerative colitis, 14 patients with active Crohn's disease and in 3 operated patients with recurrent Crohn's disease serum retinol levels and retinol-binding protein were significantly lower than in controls. Concentrations of vitamin A did not depend on the localization of inflammatory bowel disease, previous ileal resections, duration of the disease or age and sex of the patients. During successful treatment of active ulcerative colitis normalization of serum retinol levels without substitution of vitamin A was observed. Repeated determinations in patients with Crohn's disease who had low serum retinol levels in an active phase of disease revealed normal vitamin A levels in an inactive phase. The absorption of vitamins A and E in patients with inflammatory bowel disease was normal. The normal serum retinol concentrations in patients with diarrhea due to irritable bowel syndrome, and in those with anorexia nervosa exclude the influence of diarrhea and body weight itself on vitamin A levels. The results of this study indicate that serum retinol levels in patients with active inflammatory bowel disease are secondary to the decreased serum retinol-binding protein concentrations, and probably depend on the increased protein catabolism in these disorders.
The reported investigations of haemoglobin (Hb) concentration in stools of healthy subjects and patients with digestive tract diseases were carried out for determining the physiological value of blood loss into the digestive tract, and for comparing the sensitivity of quantitative and qualitative tests for demonstration of occult blood in stools in cases of colonic neoplasms. The qualitative Haemoccult test was compared to the quantitative test based on heme conversion to porphyrins by iron decoupling, which makes possible determination of total Hb content in stools and measurement of the so called intestinal fraction which develops as a result of Hb conversion to porphyrins in the upper digestive tract.
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