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Biomedical subjects

R Vejlsgaard

Publications and source records attributed to R Vejlsgaard.

At least 37 records · Page 2Linked to original sources
PubMed1986

Latamoxef versus carbenicillin plus gentamicin or carbenicillin plus mecillinam in leukopenic, febrile patients with solid tumors.

Sixty-six febrile episodes associated with leukopenia were observed in 56 patients with solid tumors, WBC less than 1.5 X 10(9)/l and temperature greater than or equal to 38.5 degrees C. Stratification to antibiotic treatment regimen was made with regard to prior cis-dichlorodiamineplatinum (cis-platinum) treatment or not. Patients who had received no cis-platinum were randomized between carbenicillin 10 g every 8 h plus gentamicin 80 mg every 8 h or latamoxef 2 g every 8 h (group I). Patients having received cis-platinum were treated with carbenicillin 10 g every 8 h plus mecillinam 800 mg every 8 h or latamoxef 2 g every 8 h (group II). The first dose of latamoxef was preceded by 10 mg of vitamin K i.v. In group I, clinical response was observed in 10 of 19 febrile episodes (52.6%) treated with carbenicillin plus gentamicin and in 10 of 14 (71.4%) treated with latamoxef (p greater than 0.05). In group II, 6 of 14 febrile episodes treated with carbenicillin plus mecillinam responded (42.9%) while 11 of 19 (57.9%) responded to latamoxef (p greater than 0.05). No bleeding due to antibiotic treatment was observed. No statistical difference between standard antibiotic therapy and latamoxef was seen in this subset of patients.

Adult↗
PubMed1985

Medical demography in Denmark. I. From a deficit to a surplus of doctors.

In the 1970s and beginning of the 1980s Denmark like other western countries has experienced a substantial growth in the number of medical doctors. Throughout the country, the doctor population ratio has improved considerably, a number of new specialised methods of examination and treatment have been started, and the need for doctors to work overtime has largely been abolished. At the same time, however, the growth in the number of doctors has also given rise to problems of postgraduate education, unemployment, the emigration. Furthermore, there has been political anxiety about the impact of an ever growing supply of new doctors on the continuous growth in health expenditure. This article briefly describes the development in the number of doctors through the last decades and the status of the current employment of doctors. Problems created by the growth in the number of doctors, and various initiatives to solve the problems and limit the growth in the supply of doctors are examined. A subsequent article will discuss and elucidate the future development in supply and demand on the employment market for doctors. The article begins with a short outline of the Danish health care system.

Denmark↗
PubMed1985

Medical demography in Denmark. II. Prognoses--how to achieve equilibrium?

In keeping with efforts made during the 1970s to achieve a better balance between supply and demand on the employment marker for doctors, several detailed prognoses have been produced for the future development of supply with regard to sex and age structure, mortality, early retirement, frequency of emigration, specialist distribution etc. On the demand side, the prognoses are of a more evaluating character partly because there has not been sufficiently effective methods developed to predict the growth of the demand, partly because the future demand is dependent on a wide range of health, technological, economic and political factors which can hardly be predicted. This article is an account of the main tendencies anticipated in the expansion of the supply of medical doctors in the coming decades. Further, the possibilities for achieving equilibrium between supply and demand in the future employment market will be discussed.

Denmark↗
PubMed1985

Postgraduate medical education in Denmark. Present status and perspectives.

The Danish Specialist Board--the advisory organ to the National Board of Health in all matters of medical education--was established 50 years ago. In 1979 a complete new scheme of organisation of postgraduate medical education was introduced, now involving political and administrative instances directly in the decisions. The Specialist Board was enlarged and extended with three permanent subcommitees dealing respectively, with evaluation of education and authorization, theoretical education, and clinical education. A description of the various organs and their functions is presented. New rules concerning training within the 20 basic specialties and 19 subspecialties and in general medicine was layed down in 1982. The frames of postgraduate medical education and the main lines in the clinical training course and theoretical programme is described. A series of problems have accumulated over the last 10-15 years, mainly due to developments in medical demography and new conditions for clinical education related to a new agreement between the hospital administrations and the Association of Junior Hospital Doctors. On basis of an analysis made by the Specialist Board a plan has been designed with the purpose to establish a staff reform in the hospital departments and to transform postgraduate clinical education of doctors to a formally planned and supervised programme.

Denmark↗
PubMed1982

Bacteriuria caused by Acinetobacter calcoaceticus biovars in a normal population and in general practice.

A total of 14 strains of Acinetobacter calcoaceticus biovar anitratus and 93 strains of A. calcoaceticus biovar lwoffi from a total of 97 patients participating in studies of significant bacteriuria were cultured. These studies involved an interview survey of asymptomatic significant bacteriuria and a multiple-center investigation of urinary tract infection diagnosed in general practice. Antibiotic susceptibilities of the strains as determined by a disk diffusion technique were generally in agreement with the results in the available literature, although we found high activity exhibited by ampicillin, cephalosporin, chloramphenicol, erythromycin, and streptomycin. The following resistance patterns were seen. (i) The strains from the interview survey were more often resistant to ampicillin, oxacillin, and tetracycline than were strains from the general practice study. (ii) More biovar anitratus strains than biovar lwoffi strains were resistant to chloramphenicol, erythromycin, and mecillinam. (iii) More biovar anitratus strains than biovar lwoffi strains were resistant to carbenicillin in the interview survey. The literature relevant to the incidence and significance of A. calcoaceticus biovars in urinary cultures, as well as predisposing factors, was reviewed. The incidence of these organisms in significant bacteriuria seems to be increasing. We concluded that A. calcoaceticus biovars can cause urinary tract infection in abnormal hosts as well as in basically healthy individuals.

Acinetobacter↗
PubMed1981

Candida Pericarditis in a patients with leukaemia.

Candidal pericarditis is extremely rare. Its clinical diagnosis and successful treatment has not been reported earlier. A case reported of a 30-year-old male with acute lymphoblastic leukaemia complicated with exudative pleuropericarditis, probably initially of leukaemic origin. Following persisting fever cultures of blood and pericardial fluid yielded massive growth of candida albicans. After 3 weeks treatment with intravenous amphotericin B, flucytosine and miconazole, the blood and pericardial fluid was sterilized. A sufficient amphotericin B concentration in the pericardial fluid was obtained without local instillation.

Adult↗
PubMed1981

Pivmecillinam plus pivampicillin in complicated urinary tract infection. Double-blind comparison of the combination pivmecillinam/pivampicillin and pivmecillinam alone in patients with urinary tract infection.

Twenty-six surgical-urological patients with severe underlying diseases of the urinary tract and an acute urinary tract infection received a 10-day treatment with either pivmecillinam, 400 mg three times daily (twelve patients), or the fixed dose combination of pivmecillinam/pivampicillin (pivmecillinam 200 mg plus pivampicillin 250 mg) three times daily (fourteen patients). Eleven of the fourteen patients given combined therapy were cured bacteriologically, compared to only four out of twelve patients taking pivmecillinam alone. Clinical success was achieved in eleven out of fourteen patients who received combination therapy and in seven out of twelve subjects given pivmecillinam. Mild gastro-intestinal discomfort was recorded in a few patients in both treatment groups. The results suggest that the combination of pivmecillinam and pivampicillin is a promising alternative in patients with complicated urinary tract infections.

Administration, Oral↗
PubMed1981

Does antibacterial ointment applied to urethral meatus in women prevent recurrent cystitis?

In a double-blind placebo controlled clinical trial the preventive value of the antibacterial ointment povidone-iodine 10% (Isodine, Betadine) applied to urethral meatus was evaluated in 17 females suffering from recurrent urinary tract infections (UTI). The patients applied povidone-iodine respectively placebo ointment twice daily and before sexual intercourse in two 6-month periods in a cross-over design. No difference was observed in number of UTI during povidone-iodine and placebo prophylaxis. A decrease in the incidence of UTI was seen during application of any ointment. The antibacterial properties of povidone-iodine ointment is unimportant in the prophylaxis of reinfections as also indicated from urethral and periurethral cultures during the study revealing no change in pathogenic bacterial flora. An improved perineal hygiene in the context of application of ointment may be responsible for the reduction in UTI incidence in females with recurrent cystitis.

Administration, Topical↗