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Biomedical subjects

R Vejlsgaard

Publications and source records attributed to R Vejlsgaard.

87 records · Page 5Linked to original sources
PubMed1970

Investigation of the penicillinase activity in L colonies of Staphylococcus aureus.

Penicillinase-producing strains of Staphylococcus aureus are transformed into stable L colonies by 70 to 100 subcultures on methicillin-containing medium with a suitable high osmolarity. During transformation, the penicillinase activity is lost. This loss in activity is not the result of only the penicillinase-negative mutants transforming to L colonies. If unstable L colonies are filtered through 0.45-mum membrane filters immediately after transformation, still no penicillinase activity is seen; this is also the case if the filtrated L colonies are reverted into coccal forms. The mechanism responsible for the loss of penicillinase activity is discussed. A loss of the penicillinase plasmid is proposed as the most reasonable explanation.

Bacillus subtilis↗
PubMedDate not supplied

Study of bacteria in the nasal cavity and nasopharynx during naturally acquired common colds.

It was the purpose of this study to examine whether the number of bacteria in the nose and nasopharynx changes during a common cold. Samples for bacteriological culture were taken from the nasal cavity of 29 and from the nasopharynx of 26 adult patients with naturally acquired colds. The bacteriological samples were taken on days 2, 4, 8 16, 32 and 64 after the first nasal symptoms. The results showed that there were few pathogenic bacteria in the nasal cavity and nasopharynx. There was no tendency to an increase in the number of positive cultures during the cold, although most patients had macroscopically purulent discharge on days 3-5. In conclusion, the study indicates that during an uncomplicated common cold, a bacterial infection is not responsible for the occurrence of purulent nasal discharge which may be a direct consequence of the viral infection.

Adult↗
PubMedDate not supplied

Amoxicillin/clavulanate treatment in secretory otitis media. Bacteriological findings in the nasopharynx.

A double blind, placebo controlled study was undertaken to evaluate the antibiotic impact of amoxicillin/clavulanate acid on the nasopharyngeal flora in children treated for 4 weeks for secretory otitis media (SOM). In 131 children who received antibiotic, a significant fall in H. influenzae and S. pneumoniae was observed in comparison to 133 children who received placebo. Beta-haemolytic streptococci and S. aureus were less frequent and did not decrease significantly. One month after discontinuation of treatment the nasopharyngeal bacterial flora was restored to pretreatment level. Seasonal variation was found only for S. pneumoniae. No persistent beta-lactamase producing H. influenzae was noticed. In the light of previously published results this study confirms that the nasopharyngeal flora plays an aetiological role in the development of SOM in children, and that the used antibiotic did not disturb the nasopharyngeal flora in the long run.

Amoxicillin↗