PubMed Health⌕ Search

Biomedical subjects

R Vejlsgaard

Publications and source records attributed to R Vejlsgaard.

At least 73 records · Page 4Linked to original sources
PubMed1976

Kinetics and dose calculations of amikacin in the newborn.

The pharmacokinetics of a new aminoglycoside, amikacin, was evaluated in 37 infants between 1 and 34 days old. Fifteen were below 2,500 gm in weight. Initial studies, including intravenous infusion in some of the infants, indicated that the disposition of amikacin was best described by a 2 compartment model. The absorption was evaluated in 8 of the infants after intramuscular injection of 7.5 mg amikacin per kilogram of body weight. The absorption rate, estimated by the tmax, was significantly faster than reported in adults. The total body clearance and apparent volume of distribution were studied in 22 infants after the same dose of amikacin intramuscularly. The body clearance expressed in relation to body surface or body weight was significantly less than in adults and correlated with the postnatal age. No correlation could be demonstrated between clearance and gestational age or birth weight. The volume of distribution per kilogram was significantly greater than in adults. On the basis of the derived kinetic parameters, a dose schedule is presented. In 5 children there was a reasonable agreement between the measured and predicted serum levels.

Absorption↗
PubMed1976

Bacteriological and clinical evaluation of different dialysate delivery systems.

In the period 1964-74 four different dialysate delivery systems have been used in our department. 1) Central mixing of dialysate using tap water and a dialysate delivery line with "dead ends" resulting in stagnant dialysate. 2) Central mixing of dialysate with cold distilled water, otherwise equal to system 1. 3) Local mixing of dialysate with cold distilled water, delivered through a line with "dead ends" resulting in stagnant water. 4) Local mixing of dialysate with distilled water, cooled to 25 degrees C just prior to use, reduced "dead ends" and monitored constant overflow to drain through the water supply line. The bacterial contamination of the four systems was examined and related to the clinical occurrence of pyrogenic and other reactions. An improvement was noted with the change from central to local mixing of dialysate (system 3) but complete sterility and virtual freedom from clinical reactions were first obtained in system 4. It is concluded that the use of sterile or near sterile dialysate is recommendable.

Bacterial Infections↗
PubMed1975

Clinical evaluation of a novel beta-lactam antibiotic: pivmecillinam (FL 1039).

Pivmecillinam, a new penicillin-like antibiotic, is a member of the amidinopenicillanic acid group. Its mode of action differs from that of the classical penicillins and it exhibits no cross-resistance with them. Fifty-two gerontopsychiatric patients, median age 81 years, with E. coli, Klebsiella, and Proteus bacteriurias were divided into three comparable groups. In a ten week open clinical trial the patients were treated with pivmecillinam, pivampicillin or the two drugs given alternately in doses reduced in stages. The bacteriuria in all groups cleared almost completely in three days. Pivmecillinam compared favourably with pivampicillin especially at the end of the reduced medication. The alternating treatment seemed to be superior to treatment with either drug administered separately. No development of resistance was observed. No toxic effect on the liver, kidney, or bone marrow was seen in any of the three groups. In the group receiving pivmecillinam alone, no ampicillin-like skin rashes occurred.

Aged↗
PubMed1975

Urinary tract infection and wound infection in kidney transplant patients.

The frequency of urinary tract and wound infections was studied in 53 patients most of whom had received kidneys from donors without heart action. Urinary infection was demonstrated soon after the transplantation in 46 out of 47 with functioning kidneys. Recurrent infections took place during the first 3 months and still half of the patients were infected or under treatment 6 months after the operation. The urinary infection seems mainly to arise via indwelling catheters. Wound infections were demonstrated in 18 out of the 53 patients and in addition abscess formation took place in 9 of these. In the majority of the infected wounds previous infected drains were demonstrated. In all, 36 of the patients had infected drains, the use of which therefore is to be avoided.

Abscess↗