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Biomedical subjects

R W Lightfoot

Publications and source records attributed to R W Lightfoot.

At least 37 records · Page 2Linked to original sources
PubMed1987

Interleukin-1-production by monocytes from patients with systemic lupus erythematosus.

Production of interleukin-1 (IL-1) by glass-adherent monocytes from 18 patients with systemic lupus erythematosus (SLE) was measured. Patients were divided into three groups according to disease activity. A deficient production of IL-1 was found in monocytes of SLE patients both without stimulation and after stimulation with 5 micrograms of lipopolysaccharide. The decreased production correlated with the degree of disease. Addition of phorbol myristate acetate to monocytes caused only partial normalization of the decreased IL-1 production. The IL-1 deficiency in SLE is postulated to be a part of complex abnormalities of cell-mediated immunity in this disease.

Female↗
PubMed1986

Effect of coexistent serum DNA on qualitative properties of anti-DNA antibodies.

We have explored the possibility that inapparent DNA in serum from patients with systemic lupus erythematosus can occupy anti-DNA combining sites and alter the apparent qualitative properties of such an antibody. DNAse digestion of such sera altered both the association rate of anti-DNA with 125I-DNA and the slope of binding isotherms in Scathchard analysis, although no immunoprecipitable DNA was detected in these sera. The association rate of serum after DNAse digestion was a better correlate of nephritis and disease activity. These findings suggest that DNA not detectable by counterimmunoelectrophoresis may affect assessment of qualitative properties of anti-DNA without affecting overall antibody titer, and that the association rate after DNAse digestion of serum remains one of the best correlates of disease activity. Our data further suggest that future qualitative studies of anti-DNA behavior utilize plasma rather than serum to avoid the artifact reported here.

Antibody Affinity↗
PubMed1985

Antihyperuricemic properties of amflutizole in gout.

The antihyperuricemic properties of amflutizole were investigated in studies designed to determine its efficacy and mechanisms of action in individuals with gout and hyperuricemia. In a randomized double blind, multiple dose, crossover study of 29 patients, amflutizole caused a significant dose dependent reduction in serum urate concentrations. Mean serum urate concentrations decreased significantly from 9.6 +/- 1.5 mg/dl to 7.2 +/- 1.3 mg/dl with the 500 mg dosage (p less than 0.01). Detailed studies in 5 patients demonstrated evidence for modest xanthine oxidase inhibition. However, the majority of the antihyperuricemic effect was derived from an enhanced renal clearance of uric acid. Although the drug has significant antihyperuricemic properties, these were inadequate to achieve adequate control of the serum urate concentration in hyperuricemia and gout at the doses utilized.

Adult↗
PubMed1984

Gouty arthritis: a prospective radiographic evaluation of sixty patients.

A prospective analysis of 60 patients with gout was undertaken to evaluate the radiographic spectrum of gouty arthritis in patients treated in the era of hypouricemic therapy. Twenty-two of these patients were clinically tophaceous; 36 were considered to have radiographic findings diagnostic of gouty arthritis by strict radiographic criteria. Up to 24% of the patients denied symptoms in joints with radiographic changes of gout; 42% with no evidence of tophi on clinical examination had radiographic changes characteristic of gout. Radiographic assessment can be extremely helpful in the management of gout by documenting the degree and extent of bony involvement, particularly in patients with limited symptoms or without clinical tophi.

Ankle Joint↗
PubMed1983

The radiographic diagnosis of sacroiliitis. A comparison of different views with computed tomograms of the sacroiliac joint.

Conventional radiography is the standard method of objectively identifying sacroiliitis. Single views of the sacroiliac joints can be unequivocally interpreted in 70-80% of patients with low back pain. A series of views usually correctly resolves the ambiguity in the remaining 20-30% of patients (67% correct). Computed tomography will be helpful in the few patients in whom a series of views produces equivocal interpretation.

Arthritis↗
PubMed1980

Studies of murine complement. Correlation of hypocomplementemia with other disease parameters in individual NZB/W mice and demonstration of anti-complementary material.

We have utilized a new assay for murine complement components to explore the relationship of complement titers to other parameters of disease activity in individual NZB/W female mice. Titers had fallen significantly by 6 months of age, concomitantly with the appearance of antiDNA in serum and of C3 and immunoglobulin in renal glomeruli. The period of hypocomplementemia antedating proteinuria was extremely variable. Heat stable anti-complementary material was found in serum from older NZB/W mice.

Animals↗
PubMed1980

Benoxaprofen administered once a day: determination of optimum dosage schedule.

Six centers participated in a double-blind crossover study in patients with rheumatoid arthritis (RA) and osteoarthritis to evaluate the most advantageous timing of the daily dose of benoxaprofen. The study results revealed no significant difference between the morning and evening dose administered at a daily dose of 600 mg; however, more patients with RA preferred the evening dose.

Adult↗
PubMed1974

Gonococcal disease.

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Antibodies, Bacterial↗