Nucleosome assembly: more than electric in the making?
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DNA↗
Biomedical subjects
Robert N Dutnall
Publications and source records attributed to Robert N Dutnall.
Cracking the histone code: one, two, three methyls, you're out!
In this issue of Molecular Cell, Zhang et al. report the structure of a ternary complex between the SET domain histone methyltransferase DIM-5, its cofactor, and a histone H3 peptide. The insight gained from analysis of a key amino acid provides an exciting opportunity to dissect the possible functional meaning of mono-, di-, and trimethylation of histone lysine residues in vivo that will complement existing approaches in the quest to crack the histone methylation code.
Amino Acid Sequence↗
Methyl magic and HAT tricks.
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Acetylation↗